Ukunyanga

Umxholo

• Ngaphambi kokuba uthathe i-venetoclax,
• IVenetoclax inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

IVenetoclax isetyenziswa yodwa okanye idityaniswe ne-obinutuzumab (Gazyva) okanye i-rituximab (i-Rituxan) ukunyanga iintlobo ezithile ze-lymphocytic leukemia (CLL; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) okanye iintlobo ezithile ze-lymphocytic lymphoma (SLL; Uhlobo lomhlaza oluqala ikakhulu kwii-lymph node). Isetyenziswa ngokudibeneyo kunye ne-azacitidine (Vidaza), decitabine (Dacogen), okanye icytarabine njengonyango lokuqala lwe-acute myeloid leukemia (AML; uhlobo lomhlaza oluqala kwiiseli ezimhlophe zegazi) kubantu abaneminyaka engama-75 ubudala okanye abadala, okanye kubantu abadala abaneemeko zonyango ezibathintelayo ekubeni baphathwe ngamanye amayeza e-chemotherapy. IVenetoclax ikwiklasi yamayeza abizwa ngokuba yi-B-cell lymphoma-2 (BCL-2) inhibitors. Isebenza ngokuthintela isenzo seproteyini ethile emzimbeni esinceda iiseli zomhlaza zisinde. Oku kunceda ukubulala iiseli zomhlaza.

IVenetoclax iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa ngokutya kunye namanzi kube kanye ngemini. Thatha i-venetoclax ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-venetoclax ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-venetoclax, ungaphindi idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho uya kukuqala ngethamo eliphantsi le-venetoclax kwaye ngokuthe ngcembe andise idosi yakho, hayi ngaphezulu kwe kanye ngeveki kwiiveki zokuqala ezi-5 ukuba uphathwa nge-CLL okanye nge-SLL, kwaye kanye ngemini kwiintsuku zokuqala ezi-3 okanye ezi-4 ukuba unyangwa i-AML.

Ugqirha wakho unokufuna ukuphazamisa okanye ayeke unyango lwakho ukuba uneziphumo ebezingalindelekanga ezithile. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-venetoclax. Iziphumo ezithile ebezingalindelekanga, ugqirha unokukuxelela ukuba uqale ukuthatha i-venetoclax kwidosi esezantsi.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-venetoclax kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-venetoclax,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-venetoclax, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-venetoclax. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha icarlithromycin, conivaptan (Vaprisol), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole, lopinavir (eKaletra), posaconazole (Noxafil), ritonavir (Norvir, e Kaletra, Technivie ), okanye voriconazole (Vfend). Ugqirha wakho unokukuxelela ukuba ungathathi i-venetoclax ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amiodarone (Nexterone, Pacerone), bosentan (Tracleer), captopril, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), carvedilol (Coreg), ciprofloxacin (Cipro), cyclosporine (Gengraf, Neoral, Sandimmune), digoxin (Lanoxin), diltiazem (Cardizem, Cartia XT, Diltzac, Taztia, Tiazac), dronedarone (Multaq), efavirenz (Sustiva, e Atripla), erythromycin (EES, Eryc, Eryped, Eryoc-tab, , etravirine (Intelence), everolimus (Afinitor, Zortress), felodipine, fluconazole (Diflucan), modafinil (Nuvigil, Provigil), nafcillin (Nallpen), phenytoin (Dilantin, Phenytek), quinidine (eNuedextine), , rifampin (Rifadin, Rimactane, eRifamate, Rifater), sirolimus (Rapamune), ticagrelor (Brilinta), verapamil (Calan, Verelan, eTarka), okanye warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-venetoclax, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iquercetin okanye iSt.
• xelela ugqirha wakho ukuba ukhe waba neengxaki kumanqanaba akho e-potassium, i-phosphorus, okanye i-calcium egazini lakho; amanqanaba aphezulu e-uric acid egazini lakho; igawuthi (uhlobo lwesifo samathambo olubangelwa ziikristale ezibekwe kumalungu); okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba unokukhulelwa, kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango nge-venetoclax. Akufanele ukhulelwe ngexesha lonyango lwakho kunye neentsuku ezingama-30 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-venetoclax, biza ugqirha wakho.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha i-venetoclax kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-venetoclax.
• awunalo ugonyo ngaphambili, ngexesha, okanye emva konyango nge-venetoclax ngaphandle kokuthetha nogqirha wakho.
• Kuya kufuneka uyazi ukuba unokuba ne-tumor lysis syndrome (i-TLS; imeko ebangelwa kukuwohloka okukhawulezayo kweeseli zomhlaza ezinokubangela ukusilela kwezintso kunye nezinye iingxaki) ngexesha lonyango lwakho nge-venetoclax. Oku kunokwenzeka ukuba kwenzeke xa uqala unyango, kwaye ngalo lonke ixesha idosi yakho inyukile. Ukukunceda ukunciphisa umngcipheko wokufumana i-TLS kufuneka usele ubuncinci iiglasi ezi-6 ukuya kwezi-8 (ezingama-48 ukuya kuma-64 ii-ounces) zamanzi ngosuku iintsuku ezi-2 ngaphambili nangosuku lwedosi yakho yokuqala, kwaye ngalo lonke ixesha idosi yakho inyusiwe. Ukongeza ugqirha wakho uya kukunika amayeza ukuba uwathathe ngaphambi kokuqala kwaye ngexesha lonyango lwakho ukunceda ukuthintela oku. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-TLS biza ugqirha wakho kwangoko: umkhuhlane, ukugodola, isicaphucaphu, ukugabha, ukudideka, ukuphefumla kancinci, ukuxhuzula, ukubetha kwentliziyo okungaqhelekanga, umchamo omnyama okanye onamafu, ukudinwa okungaqhelekanga, okanye iintlungu zentlungu okanye edibeneyo.

Musa ukuyitya i-grapefruit, i-starfruit, okanye ii-orenji zaseSeville (ngamanye amaxesha zisetyenziswa kwi-marmalade), okanye usele ijusi yeziqhamo ze grapefruit ngelixa uthatha eli yeza.

Ukuba ukhumbula idosi ephosiweyo kwisithuba seeyure ezisi-8 zexesha owawucwangciselwe ukulithatha, thatha idosi ephosiweyo ngoko nangoko. Nangona kunjalo, ukuba ngaphezulu kweeyure eziyi-8 zidlulile ukusukela kwixesha oqhele ukuthatha ngalo i-venetoclax, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo rhoqo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uphoswa ukuthatha i-venetoclax ngaphezulu kweentsuku ezisi-7, kuya kufuneka ubize ugqirha wakho ngaphambi kokuba uthathe amanye amayeza. Ugqirha wakho unokufuna ukuqala kwakhona amayeza akho kwidosi esezantsi.

IVenetoclax inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• isicaphucaphu
• ukugabha
• ukunciphisa ukutya
• ukudinwa kakhulu
• ukudumba kweengalo okanye izandla zakho
• umqolo obuhlungu
• ithambo, umsipha, okanye iintlungu ezidibeneyo
• intlungu zesisu
• ukudumba okanye izilonda emlonyeni
• umlomo okanye umqala obuhlungu
• intloko ebuhlungu
• ukuvuza okanye impumlo ezixineneyo, ukukhohlela
• ukuqhawukelwa ngumphefumlo
• isiyezi
• irhashalala
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

• umkhuhlane wedwa okanye kunye nomqala obuhlungu, ukukhohlela, ukugodola, ukufudumala, obomvu, ulusu olubuhlungu okanye oludumbileyo, ukungxamiseka, rhoqo, okanye ukuba buhlungu komchamo, kunye nezinye iimpawu zosulelo
• ukuncipha kokuchama
• ukudumba kwemilenze yakho, amaqatha okanye iinyawo
• ukopha okungaqhelekanga okanye okunzima okanye ukugruzuka
• ulusu oluthuthu, ukuphefumla kancinci, isiyezi, ukudinwa kakhulu, ukubetha kwentliziyo okukhawulezayo

IVenetoclax inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yenza hayi tshintshela iyeza kwisikhongozeli esahlukileyo. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-venetoclax.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Venclexta^®