Inaliti yeDurvalumab

Umxholo

• Ngaphambi kokufumana inaliti ye-durvalumab,
• Inaliti ye-Durvalumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

I-Durvalumab isetyenziselwa ukunyanga umhlaza wamaphaphu ongekho mncinci (NSCLC) osasazeka kwizicubu ezikufutshane kwaye awunakususwa ngotyando kodwa khange ube mandundu emva kokuphathwa ngamanye amayeza e-chemotherapy kunye nonyango lwemitha. Inaliti ye-Durvalumab ikwasetyenziswa ngokudibeneyo ne-etoposide (i-Etopophos) kunye nokuba yi-carboplatin okanye i-cisplatin yokunyanga inqanaba elincinci lomhlaza wamaphaphu (ES-SCLC) kubantu abadala abanomhlaza osasazeke kuyo yonke imiphunga nakwezinye iindawo zomzimba. Inaliti ye-Durvalumab ikwiklasi yamayeza abizwa ngokuba zii-antibodies ze-monoclonal. Isebenza ngokunceda amajoni akho omzimba ukuba acothise okanye ayeke ukukhula kweeseli zomhlaza.

Inaliti ye-Durvalumab iza njengombane oza kungeniswa emthanjeni ngaphezulu kwemizuzu engama-60 ngugqirha okanye umongikazi esibhedlele okanye kwiziko lonyango. Unyango lomhlaza womchamo okanye i-NSCLC, ihlala inikwa kube kanye kwiiveki ezi-2 ukuba ugqirha wakho ucebisa ukuba ufumane unyango okanye i-NSCLC ukuya kunyaka omnye. Unyango lwe-ES-SCLC, ihlala inikwa kube kanye kwiiveki ezi-3 kwimijikelo emi-4 kunye namanye amayeza, kwaye ibe iyodwa kube kanye kwiiveki ezi-4 okoko ugqirha ekucebisa ukuba ufumane unyango.

Inaliti ye-Durvalumab inokubangela ukusabela okunobungozi okanye okusongela ubomi ngexesha lokufakwa. Ugqirha okanye umongikazi uya kukujonga ngokusondeleyo ngelixa ufumana ukumiliselwa kwaye kungekudala emva kokufakwa ukuze uqiniseke ukuba awunampendulo imbi kunyango. Xelela ugqirha wakho okanye umongikazi kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo ezinokuthi zenzeke ngexesha okanye emva kokufakwa ngaphakathi: ukugodola okanye ukungcangcazela, ukurhawuzelela, irhashalala, ukugungxula, ukuphefumla nzima, isiyezi, umkhuhlane, ukuziva utyhafile, umqolo obuhlungu okanye umqala wentamo yobuso bakho.

Ugqirha wakho unokunciphisa ukunyuswa kwakho, ukulibaziseka okanye ukuyeka unyango lwakho ngenaliti ye-durvalumab, okanye ukunyanga ngamayeza angaphezulu kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-durvalumab kwaye ngalo lonke ixesha ufumana idosi. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-durvalumab,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-durvalumab, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-durvalumab injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wafakelwa ilungu. Xelela ugqirha wakho ukuba ukhe unesifo sokuzimela komzimba (imeko apho amajoni omzimba ahlasela indawo esempilweni yomzimba) njengesifo sikaCrohn (imeko apho amajoni omzimba ahlasela khona umgca wokugaya obangela iintlungu, urhudo, ukwehla kobunzima bomzimba, kunye nefiva), ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kuludwe lwekholoni [amathumbu amakhulu] kunye ne-rectum), okanye i-lupus (imeko apho amajoni omzimba ahlasela izicwili kunye namalungu amaninzi kubandakanya ulusu amalungu, igazi kunye nezintso); naluphi na uhlobo lwesifo semiphunga okanye iingxaki zokuphefumla; okanye isifo sesibindi. Xelela ugqirha wakho ukuba okwangoku unyangwa usulelo.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa ufumana inaliti ye-durvalumab. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho ngenaliti ye-durvalumab kwaye ubuncinci iinyanga ezi-3 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa ufumana inaliti ye-durvalumab, tsalela ugqirha ngokukhawuleza. Inaliti ye-Durvalumab inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise xa ufumana inaliti ye-durvalumab kwaye ubuncinci iinyanga ezi-3 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti ye-Durvalumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• iintlungu zethambo okanye izihlunu
• ukudumba kweengalo okanye imilenze yakho
• ukuqhina

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukukhwehlela okutsha okanye okuya kusiba mandundu, iintlungu esifubeni, okanye ukuphefumla kancinci
• ukuba tyheli kwamehlo okanye kolusu, ukopha okanye ukugruzuka ngokulula, ukuncipha kokutya, umchamo omnyama (onetayi), iintlungu kwinxalenye ephezulu yesisu, ukudinwa kakhulu, isicaphucaphu okanye ukugabha
• urhudo, iintlungu zesisu, okanye mnyama, hlala, uncangathi, okanye ilindle eligazi
• ukuncipha kokuchama, igazi kumchamo, ukudumba emaqatheni, ukunciphisa ukutya
• umkhuhlane, ukukhohlela, ukugodola, umkhuhlane njengeempawu, ukuchama rhoqo okanye ukubabuhlungu, okanye ezinye iimpawu zosulelo
• iintloko ezingayi kuhamba okanye iintloko ezingaqhelekanga; ukudinwa kakhulu; ukunciphisa umzimba okanye inzuzo; ukwanda kwendlala okanye ukunxanwa; uziva unesiyezi okanye ufe isiqaqa; ukuziva ubanda, ukujula kwelizwi, okanye ukuqhina; ukulahleka kweenwele; utshintsho kwiimvakalelo okanye ekuziphatheni njengokuncipha kwesondo, ukuziva ucaphukile, ukudideka okanye ukulibala; isicaphucaphu okanye ukugabha; isisu esibuhlungu
• irhashalala, ukurhawuzelela, okanye ukudumba kolusu
• ukuqina kwentamo
• ukungaboni kakuhle okanye umbono ophindwe kabini, okanye ezinye iingxaki zombono
• ubomvu wamehlo okanye iintlungu

Inaliti ye-Durvalumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwisitofu se-durvalumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Imfinzi^®