Ertugliflozin

Umxholo

• Ngaphambi kokuba uthathe i-ertugliflozin,
• Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.
• I-Ertugliflozin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-ertugliflozin kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-ketoacidosis, yeka ukuthatha i-ertugliflozin kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo. Ukuba kunokwenzeka, jonga ietoni kumchamo wakho ukuba unempawu, nokuba iswekile yegazi lakho ingaphantsi kwama-250 mg / dL:

I-Ertugliflozin isetyenziswa kunye nokutya kunye nokuzilolonga, kwaye ngamanye amaxesha ngamanye amayeza, ukwehlisa amanqanaba eswekile yegazi kubantu abane-2 yeswekile (imeko apho iswekile esegazini iphezulu kakhulu kuba umzimba awuvelisi okanye usebenzise i-insulin ngesiqhelo). U-Ertugliflozin ukwiklasi yamayeza abizwa ngokuba yi-sodium-glucose co-transporter 2 (SGLT2) inhibitors. Yehlisa iswekile yegazi ngokubangela ukuba izintso zisuse iswekile eninzi kumchamo. I-Ertugliflozin ayisetyenziswanga ukunyanga isifo seswekile sokuqala (imeko apho umzimba ungayivelisi i-insulin kwaye, ngenxa yoko, awunakho ukulawula isixa seswekile esegazini) okanye isifo seswekile ketoacidosis (imeko enzulu enokuthi ikhule ukuba iswekile ephezulu yegazi ayinyangwa. ).

Ixesha elingaphezulu, abantu abanesifo seswekile kunye neswekile ephezulu yegazi banokuba neengxaki ezinzulu okanye ezisongela ubomi, kubandakanya isifo sentliziyo, ukubetha, iingxaki zezintso, ukonakala kwemithambo-luvo kunye neengxaki zamehlo. Ukuthatha amayeza, ukwenza utshintsho kwindlela yokuphila (umzekelo, ukutya, ukwenza umthambo, ukuyeka ukutshaya), kunye nokujonga iswekile yegazi rhoqo kunokunceda ukulawula isifo seswekile kunye nokuphucula impilo yakho. Olu nyango lunokunciphisa amathuba akho okuhlaselwa sisifo sentliziyo, ukubetha, okanye ezinye iingxaki ezinxulumene nesifo seswekile ezinje ngokusilela kwezintso, ukulimala kwentliziyo (ukubindeka, imilenze ebandayo okanye iinyawo; ukunciphisa amandla ezesondo kumadoda nabasetyhini), iingxaki zamehlo, kubandakanya notshintsho okanye ukulahleka kombono, okanye isifo seentsini. Ugqirha wakho kunye nabanye ababoneleli ngempilo bayakuthetha nawe ngeyona ndlela yokulawula isifo sakho seswekile.

I-Ertugliflozin iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kusasa kunye okanye ngaphandle kokutya. Thatha i-ertugliflozin malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ertugliflozin ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokukuqala ngedosi esezantsi ye-ertugliflozin kwaye ngokuthe ngcembe wandise idosi yakho.

U-Ertugliflozin ulawula uhlobo lwe-2 yeswekile kodwa akasinyangi. Qhubeka nokuthatha i-ertugliflozin nokuba uziva uphilile. Ungayeki ukuthatha i-ertugliflozin ngaphandle kokuthetha nogqirha wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ertugliflozin kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ertugliflozin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa (irhashalala, urticaria, ukudumba kobuso bakho, imilebe, ulwimi, okanye umqala, okanye ukuphefumla nzima) kwi-ertugliflozin, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-ertugliflozin. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin, eLotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (Qbrelis, Zestril), moexipril, perindopril e-Prestalia), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), kunye trandolapril (Mavik, eTarka); ii-angiotensin receptor blockers ezinje nge-azilsartan (Edarbi, e-Edarbyclor), candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, eAvalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar, e Azor, kwi-Benicar HCT, e-Tribenzor), telmisartan (Micardis, e Micardis HCT, e-Twynsta), nase-valsartan (Diovan, e-Diovan HCT, e-Exforge); i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); umchamo ('iipilisi zamanzi'); kunye ne-insulin okanye amayeza omlomo kwisifo seswekile njenge-chlorpropamide (i-Diabinese), i-glimepiride (i-Amaryl, kwi-Duetact), i-glipizide (i-Glucotrol), i-glyburide (i-DiaBeta, i-Glynase), i-tolazamide kunye ne-tolbutamide. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unedialysis kwaye ukhe unesifo sezintso. Ugqirha wakho unokukuxelela ukuba ungathathi i-ertugliflozin.
• xelela ugqirha wakho ukuba uhlala usela utywala okanye ngamanye amaxesha usela izixa ezikhulu zotywala ngexesha elifutshane (ukuzinkcinkca ngotywala), wakha wanqunyulwa, okanye ukondla ukutya okune-sodium. Kwakhona xelela ugqirha wakho ukuba ukhe wanalo uxinzelelo lwegazi oluphantsi, icholesterol ephezulu, usulelo lomchamo okanye iingxaki zomchamo, isifo sepancreatic kubandakanya ipancreatitis (ukudumba kwepancreas) okanye uqhaqho kwi-pancreas, usulelo lwegwele kwindawo yesini , ukusilela kwentliziyo, isifo semithambo esecaleni (ukunciphisa imithambo yegazi ezinyaweni, emilenzeni, okanye ezingalweni kubangela ukuba ndindisholo, iintlungu, okanye ukubanda kuloo ndawo yomzimba), i-neuropathy (umonakalo wentsholongwane obangela ukurhawuzelela, ukuba ndindisholo kunye nentlungu, izandla neenyawo), izilonda ezinyaweni okanye izilonda, okanye intliziyo, izintso, okanye isifo sesibindi. Ukuba uyindoda, xelela ugqirha wakho ukuba awuzange waluswe. Tshela ugqirha wakho ukuba ngaba utya kancinci ngenxa yokugula, uqhaqho, okanye utshintsho kwindlela otya ngayo okanye ukuba awukwazi ukutya okanye ukusela ngesiqhelo ngenxa yokuba ubucaphucaphu, ukugabha, urhudo, okanye ukuba uphelelwe ngamanzi ngenxa yokuba selangeni .
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Musa ukuncancisa ngelixa uthatha i-ertugliflozin. Ukuba ukhulelwe ngelixa uthatha i-ertugliflozin, tsalela ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ertugliflozin.
• utywala kunokubangela utshintsho iswekile yegazi. Buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kotywala ngelixa uthatha i-ertugliflozin.
• Kuya kufuneka uyazi ukuba i-ertugliflozin inokubangela ukuba ube nesiyezi, ukuba nentloko elula, kunye nokuphelelwa ngamandla xa usukuma ngokukhawuleza kwindawo olele kuyo. Ukuba unale ngxaki, tsalela umnxeba ugqirha wakho. Ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume.
• buza ugqirha wakho ukuba wenzeni ukuba uyagula, uhlasele usulelo okanye umkhuhlane, amava oxinzelelo angaqhelekanga, okanye wenzakele. Ezi meko zinokuchaphazela iswekile yegazi kunye nenani le-ertugliflozin onokuyifuna.

Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Kubalulekile ukutya ukutya okusempilweni.

Landela imiyalelo kagqirha wakho malunga nokusela ngokwaneleyo ulwelo imini yonke ngelixa ukule nyango.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.

I-Ertugliflozin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuchama kakhulu, kubandakanya nasebusuku
• ukwanda kokoma
• umlomo owomileyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• Ukuchama rhoqo, okungxamisekileyo, okutshisayo, okanye okubuhlungu
• ukuncipha kwenani lomchamo
• umchamo onamafu, obomvu, opinki, okanye omdaka
• umchamo onukayo
• intlungu ye-pelvic okanye ye-rectal
• (kwabasetyhini) ivumba lobufazi, ukuphuma okumhlophe okanye okumthubi (kusenokuba namathambo okanye kujongeka njengekhitshi), okanye ukurhawuzelela kwilungu lobufazi
• (emadodeni) ukuba bomvu, ukurhawuzelela, okanye ukudumba kwelungu lobudoda; irhashalala kwilungu lobudoda; ukukhutshwa okungcolileyo kwilungu lobudoda; okanye iintlungu kulusu olujikeleze ipipi
• uziva udiniwe, ubuthathaka, okanye ungonwabanga; kunye nomkhuhlane kunye nentlungu, ukuthamba, ubomvu, kunye nokudumba kwamalungu esini okanye indawo phakathi kwamalungu esini kunye nethanga
• ukuhla ukusinda
• umkhuhlane, ukugodola, okanye ezinye iimpawu zosulelo
• iintlungu, ukuthamba, izilonda, izilonda, okanye ukudumba, indawo efudumeleyo, ebomvu kwindawo yomlenze okanye yonyawo

Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-ertugliflozin kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• urhwebo
• ukurhawuzelela
• kunzima ukugwinya
• ukudumba kobuso, umqala, ulwimi, imilebe, umlomo, okanye amehlo
• ukudinwa

Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-ketoacidosis, yeka ukuthatha i-ertugliflozin kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo. Ukuba kunokwenzeka, jonga ietoni kumchamo wakho ukuba unempawu, nokuba iswekile yegazi lakho ingaphantsi kwama-250 mg / dL:

• isicaphucaphu
• ukugabha
• indawo yesisu
• ukudinwa
• ubunzima bokuphefumla

I-Ertugliflozin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi nangexesha lonyango lwakho nge-ertugliflozin ukujonga ukuba zisebenza njani izintso zakho. Amanqanaba eswekile yegazi lakho kufuneka atshekishwe rhoqo ukumisela impendulo yakho kwi-ertugliflozin. Ugqirha wakho uya kuyalela ezinye iimvavanyo zelebhu, kubandakanya i-hemoglobin eglycosylated (HbA1c), ukujonga impendulo yakho kwi-ertugliflozin. Ugqirha wakho uya kukuxelela nendlela yokujonga impendulo yakho kolu nyango ngokulinganisa amanqanaba eswekile yegazi lakho ekhaya. Landela le miyalelo ngononophelo.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-ertugliflozin. Ngenxa yendlela la mayeza asebenza ngayo, umchamo wakho unokuvavanya ukuba une-glucose.

Kufuneka usoloko unxibe isacholo esichaza isifo seswekile ukuze uqiniseke ukuba ufumana unyango olufanelekileyo ngexesha likaxakeka.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Steglatro^®

• Segluromet^® (Equlathe i-Ertugliflozin, iMetformin)
• Mncedisi^® (Equlathe i-Ertugliflozin, iSitagliptin)