Gilteritinib

Umxholo

• Ngaphambi kokuba uthathe i-gilteritinib,
• IGilteritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Gilteritinib inokubangela iqela elinobuzaza okanye elisongela ubomi leempawu ezibizwa ngokuba sisifo sokuzahlula. Ugqirha wakho uya kukujonga ngononophelo ukuze abone ukuba uyayiphuhlisa na le syndrome. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, ukukhohlela, irhashalala, ukutyeba ngequbuliso, isiyezi, ukuncipha kokuchama, ukudumba kweengalo okanye imilenze, ukuphefumla kancinci, ukuphefumla nzima, iintlungu zesifuba, okanye iintlungu zethambo. Ezi mpawu zinokubakho ukuya kwiinyanga ezi-3 emva kokuqala unyango nge-gilteritinib. Kwisibonakaliso sokuqala sokuba uhlakulela isifo sokwahlukana, ugqirha wakho uya kukunika amayeza ukunyanga i-syndrome, kwaye unokukuxelela ukuba uyeke ukuthatha i-gilteritinib ixesha elithile.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-gilteritinib kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo.Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Gilteritinib isetyenziselwa ukunyanga uhlobo oluthile lwe-myeloid leukemia (AML) eye yanzima okanye yabuyela emva konyango ngamanye amayeza e-chemotherapy. UGilteritinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo sento ethile yendalo enokubakho enokufuneka ukunceda iiseli zomhlaza zande.

IGilteritinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye yonke imihla kunye okanye ngaphandle kokutya ubuncinci iinyanga ezi-6. Thatha i-gilteritinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-gilteritinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo ngamanzi; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokuyihlengahlengisa idosi yakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina kuxhomekeke ekubeni lukusebenzela njani na kwaye ukuba ufumana naziphi na iziphumo ebezingalindelekanga. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-gilteritinib nokuba uziva uphilile. Ungayeki ukuthatha i-gilteritinib ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-gilteritinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-gilteritinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-gilteritinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antifungals ezithile ezinje nge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), kunye ne-ketoconazole; i-clarithromycin (i-Biaxin, kwi-PrevPac); I-escitalopram (iLexapro); i-fluoxetine (Prozac); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye i-saquinavir (i-Invirase); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); nefazodone; ipioglitazone (Actos); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); kunye ne-sertraline (iZoloft). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-gilteritinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wanaso okanye ukhe ube nesongezelelo sexesha le-QT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ukulahleka kwengqondo, ukuxhuzula, okanye ukufa ngesiquphe) ukubetha kwentliziyo okukhawulezayo, okukhawulezayo, okanye okungaqhelekanga; okanye amanqanaba asezantsi e-potassium okanye yemagniziyam egazini lakho.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. Wena okanye iqabane lakho akufuneki ukuba ukhulelwe ngelixa uthatha i-gilteritinib. Ukuba ungumfazi, kuya kufuneka ukuba ube novavanyo lokukhulelwa ubuncinci kwiintsuku ezisi-7 ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ukunqanda ukukhulelwa ngexesha lonyango kunye neenyanga ezi-4 emva kwedosi yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-gilteritinib, biza ugqirha wakho. UGilteritinib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngexesha lonyango lwakho kunye ne-gilteritinib kunye neenyanga ezi-2 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 ngaphambi kwedosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IGilteritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intlungu edibeneyo okanye yemisipha
• ukudinwa kakhulu
• isicaphucaphu
• ukugabha
• urhudo
• izilonda zomlomo
• utshintsho kwisakhono sokungcamla ukutya
• intloko ebuhlungu
• Ukuphelelwa ngumdla wokutya
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukuxhuzula; intloko ebuhlungu; ukunciphisa ukuqaphela; ukudideka; okanye utshintsho lombono
• ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga; isiqaqa; ukulahleka kwengqondo; okanye ukuxhuzula
• iintlungu eziqhubekayo eziqala kwindawo yesisu kodwa zinokusasazeka emqolo ezinokuthi zenzeke okanye ngaphandle kwesicefecefe kunye nokugabha

IGilteritinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-gilteritinib. Ugqirha wakho uya ku-odola iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-gilteritinib. Ugqirha wakho unokuyalela i-electrocardiogram (i-ECG; uvavanyo olulinganisa umsebenzi wombane entliziyweni) ngaphambi nangexesha lonyango lwakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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