Upadacitinib

Umxholo

• Ngaphambi kokuthatha i-upadacitinib,
• I-Upadacitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Ukuthatha i-upadacitinib kunokunciphisa ukubanakho kwakho ukulwa nosulelo kwaye kwandise umngcipheko wokuba ufumane usulelo olubi, kubandakanya ukungunda okunamandla, ibhaktiriya, okanye usulelo lwentsholongwane olusasazeka emzimbeni. Ezi zifo zingafuna ukunyangwa esibhedlele kwaye zingabangela ukufa. Tshela ugqirha wakho ukuba uhlala ufumana naluphi na uhlobo losulelo okanye ukuba ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Oku kubandakanya usulelo oluncinci (njengokusikwa okuvulekileyo okanye izilonda), usulelo olufikayo (olufana nezilonda ezibandayo), kunye nosulelo olungapheliyo olungapheliyo. Xelela ugqirha wakho ukuba ukhe unesifo seswekile, intsholongwane (i-HIV), ufumene isifo se-immunodeficiency syndrome (i-AIDS), isifo semiphunga, okanye enye imeko echaphazela amajoni akho Kuya kufuneka uxelele ugqirha wakho ukuba uhlala okanye wakha waphila kwiindawo ezifana ne-Ohio okanye i-Mississippi river valleys apho kukho izifo zokungunda ezixhaphakileyo. Buza ugqirha wakho ukuba awuqinisekanga ukuba ezi zifo zixhaphakile kwindawo yakho. Xelela ugqirha wakho ukuba uthatha amayeza anciphisa umsebenzi wamajoni omzimba afana nala alandelayo: azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate (Otrexup, Rasuvo , Trexall); i-steroids kubandakanya i-dexamethasone, i-methylprednisolone (Medrol), i-prednisolone (i-Prelone), kunye ne-prednisone (iRayos); isulfasalazine; okanye itacrolimus (Astagraf, Envarsus XR, Prograf).

Ugqirha wakho uya kukubeka esweni ngeempawu zosulelo ngexesha nasemva konyango lwakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngaphambi kokuba uqale unyango lwakho okanye ukuba unazo naziphi na kwezi mpawu zilandelayo okanye emva nje konyango lwakho, tsalela umnxeba kwangoko: fiva; ukubila; Ukugodola; iintlungu zemisipha; ukukhohlela; ukuqhawukelwa ngumphefumlo; ukuhla ukusinda; ulusu olufudumeleyo, olubomvu, okanye olubuhlungu; izilonda eluswini; rhoqo, ebuhlungu, okanye evuthayo xa uchama; urhudo, okanye ukudinwa okugqithisileyo.

Usenokuba sele wosulelwe sisifo sephepha (i-TB; isifo esibuhlungu semiphunga) kodwa ungabi nazimpawu zesi sifo. Kule meko, ukuthatha i-upadacitinib kunokwenza usulelo lwakho lube lubi kakhulu kwaye kubangele ukuba ube neempawu. Ugqirha wakho uza kwenza uvavanyo lolusu ukuze abone ukuba unesifo se-TB esingasebenziyo phambi kokuba uqale unyango lwakho nge-upadacitinib. Ukuba kunyanzelekile, ugqirha wakho uya kukunika amayeza ukunyanga olu sulelo ngaphambi kokuba uqale usebenzise i-upadacitinib. Xelela ugqirha wakho ukuba ukhe wakha okanye wakha wanayo na i-TB, ukuba ngaba wakhe wahlala okanye watyelela ilizwe apho ixhaphake kakhulu i-TB, okanye ukuba wakhe wakunye nomntu one-TB. Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-TB, okanye ukuba uvela kwezi mpawu ngexesha lonyango lwakho, tsalela umnxeba kwangoko: ukukhohlela, ukukhohlela umchamo wegazi, ukwehla kobunzima, ukulahleka kwethoni yezihlunu, okanye umkhuhlane.

Ukuthatha i-upadacitinib kunokunyusa umngcipheko wokuba uphuhlise i-lymphoma (umhlaza oqala kwiiseli ezilwa nosulelo) okanye ezinye iintlobo zomhlaza njengomhlaza wolusu. Tshela ugqirha wakho ukuba ukhe wanalo naluphi na uhlobo lomhlaza.

I-Upadacitinib inokunyusa umngcipheko wokuqina kwegazi emiphungeni okanye emilenzeni. Ukuba ufumana naziphi na iziphumo ebezingalindelekanga, biza ugqirha wakho okanye ufumane unyango olukhawulezileyo: ukutyumza iintlungu zesifuba okanye ubunzima besifuba; ukuqhawukelwa ngumphefumlo; ukukhohlela; iintlungu, ukufudumala, ubomvu, ukudumba, okanye ukuthamba komlenze; okanye ubushushu obubandayo ezingalweni, ezandleni, okanye emilenzeni; okanye iintlungu zemisipha.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-upadacitinib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-upadacitinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya kunye noLawulo lweziyobisi (FDA) http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko (s) wokuthatha i-upadacitinib.

I-Upadacitinib isetyenziswa yodwa okanye namanye amayeza ukunyanga isifo samathambo (imeko apho umzimba uhlasela amalungu ayo ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantu abangaphendulanga kakuhle kwi-methotrexate (Otrexup, Rasuvo, Trexall). I-Upadacitinib ikwiklasi yamayeza abizwa ngokuba nguJanus kinase (JAK) inhibitors. Isebenza ngokunciphisa umsebenzi wamajoni omzimba.

I-Upadacitinib iza njengepilisi ekhulisiweyo (esebenza ixesha elide). Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Thatha i-upadacitinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-upadacitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi zokukhululwa ezandisiweyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokufuna ukuba ayeke unyango okwexeshana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-upadacitinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-upadacitinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi zokukhupha ezandisiweyo. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza athile okubambisa anje nge-itraconazole (Onmel, Sporanox) kunye ne ketoconazole; i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Naprosyn, Aleve); i-barbiturates efana ne-phenobarbital okanye i-phenytoin (iDilantin, Phenytek); carbamazepine (Carbatrol, Tegretol, Equetro, nabanye); i-clarithromycin (i-Biaxin, kwi-Prevpac); enzalutamide (Xtandi); amayeza athile e-HIV kubandakanya i-efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye ne-saquinavir (Invirase); nefazodone; irifabutin (Mycobutin); okanye i-rifampin (iRifadin, iRimactane, eRifamate, eRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-upadacitinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• Tshela ugqirha wakho ukuba unezilonda (izilonda kwimbombo yesisu sakho okanye amathumbu), i-diverticulitis (ukuvuvukala kwimbumba yamathumbu amakhulu), i-herpes zoster (i-shingles; ukugqithisa okungenzeka kubantu abaye banenkukhu yenkukhu ngaphambili ), okanye i-anemia (inani elisezantsi kuneliqhelekileyo leeseli ezibomvu zegazi), okanye isifo sesibindi, kubandakanya i-hepatitis B okanye uC.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga kuvavanyo lokukhulelwa ngaphambi kokuba uqale unyango nge-upadacitinib. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iiveki ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa. Ukuba ukhulelwe, biza ugqirha wakho ngokukhawuleza. I-Upadacitinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngexesha lonyango lwakho kunye ne-upadacitinib kunye neentsuku ezingama-6 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-upadacitinib.
• xelela ugqirha wakho ukuba usandula ukufumana okanye ucwangciselwe ukufumana naluphi na ugonyo. Ukuba ufuna naluphi na ugonyo, kuya kufuneka ufumane ugonyo kwaye ulinde ixesha elithile ngaphambi kokuba uqale unyango lwakho nge-upadacitinib. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Upadacitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• impumlo egobileyo okanye egobayo
• isicaphucaphu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukutyheli kolusu okanye kwamehlo, ukuphelelwa ngumdla wokutya, umchamo omnyama, okanye intshukumo yombala wodongwe
• ukuphefumla okufutshane, ukudinwa, okanye ulusu olumhlophe

I-Upadacitinib inokubangela ukonyuka kwinqanaba le-cholesterol yakho. Ugqirha wakho uya kuyala iimvavanyo zokujonga amanqanaba akho e-cholesterol ngexesha lonyango lwakho kunye ne-upadacitinib. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Upadacitinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina nokuba kukwifriji okanye kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Irinvoq^®