UFedratinib

Umxholo

• Ngaphambi kokuba uthathe i-fedratinib,
• I-Fedratinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Fedratinib inokubangela i-encephalopathy (isifo esibi nesinokubulala inkqubo ye-nervous), kubandakanya ne-Wernicke's encephalopathy (uhlobo lwe-encephalopathy olubangelwa kukungabikho kwe-thiamine [vitamin B1]). Xelela ugqirha wakho ukuba ukhe wanesiphene se-thiamine. Ukuba unazo naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-fedratinib kwaye ufowunele ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo: ubunzima bokuhamba okanye ukugcina ibhalansi, ubuthathaka bemilenze okanye iingalo eziqhubeka zisiba mbi, ukudideka, ukozela, ubunzima bokuqonda okanye ukuthetha, ukulahleka kwememori, iingxaki zombono (kubandakanya umbono ophindwe kabini kunye nokuhamba kwamehlo okungaqhelekanga), okanye utshintsho kubuntu.

Ugqirha wakho unokukunika amayeza ukunciphisa umngcipheko weziphumo ebezingalindelekanga onokuba nazo ekuthatheni i-fedratinib. Tshela ugqirha wakho ngoko nangoko ukuba unesicaphucaphu, ukugabha, urhudo, okanye ukwehla kobunzima obungangcono kunyango.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-fedratinib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-fedratinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo.Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Fedratinib isetyenziselwa ukunyanga abantu abadala abaneentlobo ezithile ze-myelofibrosis (MF; umhlaza womongo wethambo apho umongo wethambo uthathelwa indawo sisihlunu esibomvu kwaye kubangele ukuhla kwemveliso yeseli yegazi). UFedratinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

I-Fedratinib iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kanye ngemini, kunye okanye ngaphandle kokutya. Ukuthatha i-fedratinib ngesidlo esinamafutha aphezulu kunokunceda ukunciphisa isicaphucaphu kunye nokugabha. Thatha i-fedratinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-fedratinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho uya ku-odola uvavanyo lwegazi ngaphambi kunye nangexesha lonyango lwakho ukuze abone ukuba uchaphazeleka njani leli yeza. Ugqirha wakho unokunyusa okanye anciphise idosi ye-fedratinib ngexesha lonyango lwakho, okanye angakuxelela ukuba uyeke ukuthatha i-fedratinib okwethutyana okanye ngokusisigxina. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza, iziphumo zovavanyo lwakho lwelebhu, kwaye ukuba uneziphumo ebezingalindelekanga. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-fedratinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-fedratinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifilisi ze-fedratinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: clarithromycin (Biaxin, in PrevPac), diltiazem (Cardizem, Dilacor, Tiazac, others), erythromycin (EES, E-mycin, Erythrocin), idelalisib (Zydelig), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), metoprolol (Lopressor, Toprol XL, in Dutoprol, others), midazolam (Versed), nefazodone, nelfinavir (Viracept), omeprazole (Prilosec, eZegerid), ribociclib (Kisqali, Kisqali, Kisqali ), ritonavir (Norvir), ruxolitinib (Jakafi), kunye ne-saquinavir (i-Invirase). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-fedratinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-fedratinib, biza ugqirha wakho.
• Musa ukuncancisa ngexesha lonyango lwakho kunye ne-fedratinib kwaye ubuncinci inyanga e-1 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-fedratinib.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Fedratinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• ukudinwa
• ukudumba kwezihlunu
• ingalo, umlenze, okanye iintlungu zethambo
• intloko ebuhlungu
• ukutyeba kwakho
• isiyezi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukopha okungaqhelekanga okanye ukugruzuka
• umkhuhlane, ukugodola, ukukhohlela, ukuqaqanjelwa ngumchamo obuhlungu okanye rhoqo, okanye ezinye iimpawu zosulelo
• isicaphucaphu, ukudinwa kakhulu, ukugruzuka okungaqhelekanga okanye ukopha, ukunqongophala kwamandla, ukungabinamdla wokutya, iintlungu kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, okanye iimpawu ezinje ngomkhuhlane
• ukuphefumla okufutshane, ukubetha kwentliziyo okukhawulezayo, intloko ebuhlungu, isiyezi, ulusu olukhanyayo, ukudideka, okanye ukudinwa

I-Fedratinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Inrebic^®