I-Elexacaftor, iTezacaftor, kunye ne-Ivacaftor

Umxholo

• Ngaphambi kokuthatha indibaniselwano ye-elexacaftor, tezacaftor, kunye ne-ivacaftor,
• Ukudityaniswa kwe-elexacaftor, i-tezacaftor, kunye ne-ivacaftor kunokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Indibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor isetyenziselwa ukunyanga iintlobo ezithile ze-cystic fibrosis (isifo esizalwe naso esidala iingxaki ngokuphefumla, ukwetyisa, kunye nokuzala) kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu. Kufuneka isetyenziswe kuphela kubantu abanemveliso ethile yemfuza. Ugqirha wakho unokuyalela uvavanyo lwegazi ukukunceda uthathe isigqibo sokuba ngaba eliyeza lilungile na kuwe. I-Elexacaftor kunye ne-tezacaftor bakudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) yokulungisa. I-Ivacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. La mayeza asebenza ngokuphucula ukusebenza kweprotein emzimbeni ukunciphisa ukwakhiwa kwe-mucus eshinyeneyo emiphungeni kunye nokuphucula ezinye iimpawu ze-cystic fibrosis.

Indibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor iza njengeetafile zokuthatha ngomlomo. Idosi nganye yemihla ngemihla ineentlobo ezahlukeneyo zamacwecwe: ithebhulethi enye yindibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor kwaye enye ithebhulethi yi-ivacaftor. Thatha i-elexacaftor, i-tezacaftor, kunye ne-ivacaftor (amacwecwe ama-2 eorenji) rhoqo kusasa ngokutya okunamafutha kunye ne-ivacaftor (1 ithebhulethi eluhlaza okwesibhakabhaka) rhoqo ngokuhlwa kunye nokutya okunamafutha, ukwahlukana iiyure ezili-12. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha la mayeza ngokuchanekileyo. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Thatha indibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor enokutya okunamafutha okufana namaqanda, ibhotolo, amantongomane, ibhotolo yamandongomane, itshizi pizza, kunye neemveliso zobisi olupheleleyo (ezinje ngobisi olupheleleyo, itshizi kunye neyogathi). Thetha nogqirha wakho malunga nokunye ukutya okunamafutha okutya nala mayeza.

Indibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor isebenza ukulawula i-cystic fibrosis, kodwa ayiyinyangi.Qhubeka nokuthatha la mayeza nokuba uziva uphilile. Sukuyeka ukuthatha la mayeza ungakhange uthethe nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha indibaniselwano ye-elexacaftor, tezacaftor, kunye ne-ivacaftor,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-elexacaftor, i-tezacaftor, kunye ne-ivacaftor nawaphi na amanye amayeza, okanye naziphi na izithako ezikwi-elexacaftor, tezacaftor, kunye neepilisi ze-ivacaftor. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (Biaxin, kwi-PrevPac) kunye ne-erythromycin (i-EES, i-E-Mycin, i-Ery-Tab, i-Erythrocin); ii-antifungals ezithile ezinjenge fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), kunye ne voriconazole (Vfend); cholesterol-ukunciphisa amayeza (ii-statins) ezinje nge-atorvastatin (Lipitor, eCaduet), fluvastatin (Lescol), lovastatin (Altoprev), pravastatin (Pravachol), rosuvastatin (Crestor), kunye ne-simvastatin (iZocor, eVytorin); icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); i-everolimus (i-Afinitor, iZortress); iglimepiride (Amaryl); glipizide (Glucotrol); glyburide (Diabeta); izinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); icandelo; repaglinide; irifabutin (Mycobutin); irifampin (Rifadin, eRifamate, eRifater, eRimactane); i-sirolimus (iRapamune); itacrolimus (Astagraf, Prograf), okanye warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-elexacaftor, tezacaftor, okanye i-ivacaftor, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Ugqirha wakho usenokukuxelela ukuba ungathathi iwort yaseSt.John ngelixa uthatha indibaniselwano ye-elexacaftor, tezacaftor, kunye ne-ivacaftor.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha indibaniselwano ye-elexacaftor, tezacaftor, kunye ne-ivacaftor, tsalela ugqirha wakho.
• Kuya kufuneka uyazi ukuba la mayeza anokukwenza wozele. Sukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela ekuchaphazela ngayo la mayeza.

Sukutya igrapefruit okanye usele ijusi yeziqhamo xa usela la mayeza.

Ukuba ukhumbula idosi kusasa okanye ngorhatya ophosiweyo ngaphakathi kweeyure ezingama-6 zexesha obucwangciselwe ukulithatha, thatha idosi ephosiweyo kwangoko kunye nokutya okunamafutha kwaye uqhubeke neshedyuli yakho yesiqhelo. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha elimiselweyo lokuthatha idosi yakho yakusasa, thatha idosi yakusasa ephosiweyo ngokukhawuleza kwaye weqe idosi yangokuhlwa, emva koko uqhubeke neshedyuli yakho yesiqhelo. Ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha elimiselweyo lokuthatha idosi yangokuhlwa, tsiba idosi yangokuhlwa ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi yakusasa neyangokuhlwa ukwenza into ephosiweyo.

Ukudityaniswa kwe-elexacaftor, i-tezacaftor, kunye ne-ivacaftor kunokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukuphuma kwempumlo, ukuthimla, kunye nokuxinana; ifiva; ukukhohlela; okanye ezinye iimpawu zosulelo
• isisu esibuhlungu okanye ukudumba
• urhudo
• irhashalala
• irhasi
• iliso elipinki
• ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• mthubi ulusu okanye amehlo
• Ukuphelelwa ngumdla wokutya
• isicaphucaphu
• ukugabha
• izitulo ezimhlophe
• isisu esibuhlungu
• umchamo omnyama

Indibaniselwano ye-elexacaftor, i-tezacaftor, kunye ne-ivacaftor inokubangela i-cataract (ukugcwala kwelensi yamehlo enokubangela iingxaki zombono) ebantwaneni nakwishumi elivisayo. Abantwana kunye nolutsha oluthatha i-elexacaftor, i-tezacaftor, kunye ne-ivacaftor kufuneka babone ugqirha wamehlo ngaphambi nangexesha lonyango lwabo. Thetha nogqirha womntwana wakho malunga neengozi zokunika i-elexacaftor, i-tezacaftor, kunye ne-ivacaftor emntwaneni wakho.

Ukudityaniswa kwe-elexacaftor, i-tezacaftor, kunye ne-ivacaftor kunokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela uvavanyo lwamehlo (lwabantwana nolutsha) kunye novavanyo oluthile lwelebhu olufana nokuvavanywa kwesibindi ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-elexacaftor, tezacaftor, kunye ne-ivacaftor.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Trikafta^®