IPemigatinib

Umxholo

• Ngaphambi kokuba uthathe i-pemigatinib,
• I-Pemigatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Pemigatinib isetyenziswa kubantu abadala abasele befumene unyango lwangaphambili ukunyanga uhlobo oluthile lwe-cholangiocarcinoma (umhlaza we-bile duct cancer) ethe yasasazeka kwizicubu ezikufutshane okanye kwamanye amalungu omzimba kwaye ayinakususwa ngotyando. I-Pemigatinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

I-Pemigatinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla kwiintsuku ezili-14 zokuqala komjikelo weentsuku ezingama-21. Umjikelo unokuphindwa njengoko ucetyiswa ngugqirha wakho. Thatha i-pemigatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha pemigatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-pemigatinib, musa ukuthatha enye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho anganciphisa umthamo wakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga ezithile. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge pemigatinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-pemigatinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana nememigatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi zepemigatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antifungals ezifana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); carbamazepine (Epitol, Tegretol, Teril, nabanye); i-clarithromycin (i-Biaxin); erythromycin (EES, Erythrocin, abanye); amayeza athile okunyanga intsholongwane kaGawulayo (i-HIV) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, kwezinye), okanye saquinavir (Invirase); nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate); kunye ne-verapamil (Calan, Verelan, abanye). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-pemigatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unengxaki yokuginya iipilisi okanye ukuba unesifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iveki enye emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiveki e-1 emva kwethamo lakho lokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-pemigatinib, tsalela ugqirha ngokukhawuleza. I-Pemigatinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngelixa uthatha i-pemigatinib kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linokubangela ukoma kwamehlo. Ugqirha wakho angakuxelela ukuba usebenzise iinyembezi okanye iliso lokuthambisa ngexesha lonyango lwakho nge pemigatinib.

Musa ukutya isixa esikhulu segrapefruit okanye usele ijusi yeziqhamo zomdiliya ngelixa uthatha eli yeza.

Ukuba uphosa idosi yememigatinib ngaphantsi kweeyure ezi-4, thatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi nge-4 okanye iiyure ezingaphezulu, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo rhoqo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Pemigatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isicaphucaphu
• utshintsho kwincasa
• ukugabha
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukuqhina
• isisu esibuhlungu
• izilonda emilebeni, emlonyeni, nasemqaleni
• umlomo owomileyo kunye / okanye ulusu; ukuncipha kokuchama; okanye ukubetha kwentliziyo okukhawulezayo
• ukuphazamiseka kwezipikili
• ukulahleka kweenwele
• intloko ebuhlungu
• ukudinwa
• intlungu edibeneyo okanye yomqolo
• ukutshisa okanye ukuvutha kabuhlungu
• iintlungu okanye ukudumba kwezandla, iinyawo, imilenze okanye amaqatha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukungaboni kakuhle, ukudada kwiso, ukubona ukukhanya kokukhanya, okanye olunye utshintsho kumbono
• izihlunu, ukuba ndindisholo, okanye ukubetha emlonyeni

I-Pemigatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help.Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina konke ukuqeshwa nogqirha wakho, ugqirha wamehlo, kunye nelabhoratri. Ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge pemigatinib. Ugqirha wakho uya ku-odola iilebhu kunye novavanyo lwamehlo ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-pemigatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Pemazyre^®