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Dr. Wolf on Updated Findings With Capmatinib in METex14-Mutant NSCLC
Ividiyo: Dr. Wolf on Updated Findings With Capmatinib in METex14-Mutant NSCLC

Umxholo

ICapmatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo semiphunga ongekho mncinci (NSCLC) osasazeke kwamanye amalungu omzimba. I-Capmatinib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

ICapmatinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kabini yonke imihla kunye okanye ngaphandle kokutya. Thatha i-capmatinib malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-capmatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-capmatinib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokufuna ukumisa okwexeshana okanye ngokusisigxina unyango lwakho okanye unciphise idosi yakho ye-capmatinib ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho nge capmatinib.


Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-capmatinib,

  • xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-capmatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-capmatinib. Buza usokhemesti wakho uluhlu lwezithako.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amitriptyline, carbamazepine (Carbatrol, Epitol, Tegretol, nabanye); i-clarithromycin (kwi-Biaxin); clozapine (IVersacloz); ii-corticosteroids; amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye i-saquinavir (i-Invirase); itraconazole (Onmel, Sporanox, Tolsura); ketoconazole; nefazodone; oxcarbazepine (iTrileptal); phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos, eDuetact, eOseni); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, kwiRifater); rosuvastatin (Crestor, Ezallor); i-verapamil (Verelan, eTarka); okanye warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-capmatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
  • xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
  • xelela ugqirha wakho ukuba unaso okanye wakhe waba nesifo semiphunga okanye iingxaki zokuphefumla ngaphandle komhlaza wemiphunga, okanye isifo sesibindi.
  • xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-capmatinib. Kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iveki enye emva kwethamo lakho lokugqibela. Ukuba uyindoda eneqabane lomfazi elinokuthi likhulelwe, kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango kwaye ubuncinci iveki emva kwethamo lakho lokugqibela. ICapmatinib inokulimaza usana lwakho olungekazalwa. Ukuba wena okanye iqabane lakho ukhulelwe ngexesha lonyango lwakho kunye ne-capmatinib, tsalela ugqirha ngokukhawuleza.
  • xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-capmatinib kwaye ubuncinci iveki enye emva kwedosi yakho yokugqibela.
  • cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide kunye nokunxiba umnqwazi, ezinye iimpahla zokuzikhusela, iiglasi zelanga kunye nescreen selanga.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ICapmatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • ukugabha
  • isicaphucaphu
  • ukudinwa
  • ukuqhina
  • ukuhla ukusinda
  • umqolo obuhlungu
  • Ukuphelelwa ngumdla wokutya
  • ukudinwa
  • ukudumba ezandleni, iinyawo, amaqatha okanye imilenze esezantsi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

  • ukuphefumla kancinci, ukukhohlela, umkhuhlane, okanye ezinye iimpawu zosulelo
  • iintlungu zesifuba
  • iintlungu kwindawo ephezulu yesisu; ukugruzuka okanye ukopha okungaqhelekanga; umchamo omnyama; ubumthubi besikhumba namehlo; okanye ukuphelelwa ngumdla wokutya

ICapmatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).


Gcina eli yeza kwisikhongozeli, livalwe ngokuqinileyo, kwaye lingenakufikelela ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Musa ukuyisusa i-desiccant (ikhatriji encinci ebandakanyiweyo kunye neepilisi ukufunxa ukufuma) kwibhotile yakho. Lahla naziphi na iipilisi ezingasetyenziswanga kwiiveki ezi-6 emva kokuqala ukuvula ibhotile.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-capmatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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Ukuhlaziywa kokugqibela-06/15/2020

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