I-Elagolix, i-Estradiol, kunye neNorethindrone

Umxholo

• Ngaphambi kokuthatha indibaniselwano ye-elagolix, estradiol, kunye norethindrone,
• I-Elagolix, i-estradiol, kunye ne-norethindrone zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

Amayeza aqukethe i-estradiol kunye ne-norethindrone zinokunyusa umngcipheko wokuhlaselwa sisifo sentliziyo, ukubetha, kunye nokuqina kwegazi emiphungeni nasemilenzeni. Xelela ugqirha wakho ukuba uyatshaya kwaye ukhe wahlaselwa yintliziyo; ukubetha; amahlwili egazi emilenzeni, emiphungeni okanye emehlweni; isifo sentliziyo; ukukhawuleza kwentliziyo okanye okungaqhelekanga; i-thrombophilia (imeko apho igazi liyaqina ngokulula); intloko ebuhlungu; igazi elonyukayo; amanqanaba aphezulu egazi echolesterol okanye amafutha; okanye isifo seswekile esichaphazele ukujikeleza kwegazi lakho. Ugqirha wakho unokukuxelela ukuba akufuneki uthathe la mayeza ukuba unayo okanye ukhe wanayo nayiphi na kwezi meko. Ukuba wenza utyando okanye uza kulala ebhedini, ugqirha wakho unokufuna ukuba uyeke ukuthatha la mayeza ubuncinci iiveki ezi-4 ukuya kwezi-6 ngaphambi kotyando okanye indawo yokulala.

Ukuba ufumana enye yeempembelelo ezilandelayo, biza ugqirha wakho ngokukhawuleza: ngokukhawuleza, intloko ebuhlungu; ukulahleka kombono ngesiquphe okanye ngokupheleleyo; umbono kabini; iingxaki zokuthetha; isiyezi okanye ukudinwa; ubuthathaka okanye ukuphazamiseka kwengalo okanye umlenze; ukutyumza iintlungu zesifuba okanye ubunzima besifuba; ukukhohlela igazi; ukuphefumla ngokukhawuleza; okanye intlungu, ukuthamba, okanye ubomvu kumlenze omnye.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-elagolix, estradiol, kunye ne-norethindrone kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko (s) wokuthatha i-elagolix, i-estradiol, kunye ne-norethindrone.

Indibaniselwano ye-elagolix, i-estradiol, kunye ne-norethindrone isetyenziselwa ukunyanga ukuphuma kwegazi okunzima okubangelwa yi-uterine fibroids (ukukhula kwisibeleko awungomhlaza). U-Elagolix ukwiklasi yamayeza abizwa ngokuba yi-gonadotropin-releasing hormone (GnRH) receptor antagonists. I-Estradiol ikudidi lwamayeza abizwa ngokuba zihomoni ze-estrogen. INorethindrone ikudidi lwamayeza abizwa ngokuba ziiprogestins. I-Elagolix isebenza ngokunciphisa inani lamahomoni athile emzimbeni. I-Estradiol isebenza ngokutshintsha i-estrogen edla ngokuveliswa ngumzimba. I-Norethindrone isebenza ngokunqanda ubume besibeleko ekukhuleni nangokubangela ukuba isibeleko sivelise iihomoni ezithile.

Umdibaniso we-elagolix, i-estradiol, kunye ne-norethindrone iza njengee-capsules zokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini imihla ukuya kwiinyanga ezingama-24. Eli yeza liza kwiphakheji equlathe iintsuku ezingama-28 zonyango. Iphakheji nganye yedosi yeeveki ineentlobo ezimbini ezahlukeneyo zeephilisi, ezisi-7 ziqulathe indibaniselwano ye-elagolix, i-estradiol, kunye ne-norethindrone (iicapsule ezimhlophe namhlophe) kunye ne-7 equkethe i-elagolix (njengezingxobo eziluhlaza namhlophe). Thatha i-elagolix, i-estradiol, kunye ne-norethindrone (1 capsule) rhoqo kusasa kwaye emva koko uthathe i-elagolix (1 capsule) rhoqo ngokuhlwa. Thatha i-elagolix, i-estradiol, kunye ne-norethindrone ngeenxa zonke ngaxeshanye yonke imihla.Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-elagolix, i-estradiol, kunye ne-norethindrone ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokukunika okanye acebise nge-calcium kunye novithamini D ongeza ukuba uthathe ngexesha lonyango lwakho. Kuya kufuneka uthathe ezi zongezelelo njengoko kuyalelwa ngugqirha.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha indibaniselwano ye-elagolix, estradiol, kunye norethindrone,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba u-alegolix, i-estradiol, i-norethindrone, i-aspirin, i-tartrazine (idayi etyheli efumaneka kwamanye amayeza), nawaphi na amanye amayeza, okanye naziphi na izithako kwi-elagolix, estradiol, kunye ne-norethindrone capsules. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha icyclosporine (Gengraf, Neoral, Sandimmune) okanye gemfibrozil (Lopid). Ugqirha wakho unokukuxelela ukuba ungathathi indibaniselwano ye-elagolix, estradiol, kunye ne-norethindrone ukuba uthatha elinye okanye nangaphezulu la mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: digoxin (Lanoxin); ketoconazole; levothyroxine (Levoxyl, Synthroid, Tirosint, nabanye); imidazolam (iNozilam); phenytoin (iDilantin, iPhenytek); Iiproton pump inhibitors ezinje nge-dexlansoprazole (Dexilant), esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, eTalicia, eYosprala, eZegred), pantoprazole (Protonix), kunye rabeprazole (Aciphex) irifampin (Rifadin, eRifamate, eRifater); irosuvastatin (Crestor); kunye nee-steroids ezinje nge-dexamethasone (Hemady), methylprednisolone (Medrol), prednisone, kunye ne-prednisolone (Orapred ODT, Pediapred, Prelone). Kwakhona xelela ugqirha wakho okanye usokhemesti ukuba uthatha iivithamini okanye izongezo zeeminerali ezinentsimbi. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-elagolix, estradiol, kunye ne-norethindrone, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe waba nomhlaza wamabele; umhlaza womlomo wesibeleko, ubufazi, okanye ulwelwesi lwesibeleko; i-osteoporosis (imeko apho amathambo ebhityile kwaye kunokwenzeka ukuba aphuke); ukopha okungaqhelekanga kwilungu lobufazi; isifo peripheral semithambo (ukuhamba kakubi kwimithambo yegazi); Intliziyo okanye isifo sesibindi okanye nayiphi na enye ingxaki yesibindi. Ugqirha wakho unokukuxelela ukuba ungathathi indibaniselwano ye-elagolix, estradiol, kunye ne-norethindrone.
• xelela ugqirha wakho ukuba wakha waphula amathambo; ukudakumba, ixhala, utshintsho olungaqhelekanga kwindlela oziphethe ngayo okanye kwiimvakalelo, okanye iingcinga malunga nokuzama ukuzibulala; isifo sesinyongo; i-jaundice (ukutyheli kolusu okanye amehlo); iingxaki ze-thyroid; okanye ukungoneli kwe-adrenal (imeko apho amadlala eadrenal engavelisi ngokwaneleyo iihomoni ezithile ezifunekayo kwimisebenzi ebalulekileyo yomzimba).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Musa ukuthatha i-elagolix, i-estradiol, kunye ne-norethindrone ukuba ukhulelwe okanye ucinga ukuba ukhulelwe. Ugqirha wakho uza kwenza uvavanyo lokukhulelwa ngaphambi kokuqala unyango okanye akuxelele ukuba uqale unyango lwakho kwiintsuku ezisi-7 emva kokuba uqale ukuya exesheni ukuze uqiniseke ukuba awukhulelwe xa uthatha i-elagolix, i-estradiol kunye ne-norethindrone. I-Elagolix, i-estradiol, kunye ne-norethindrone zinokuphazamisa isenzo sezinto ezithile zokuthintela ukukhawula, ngenxa yoko akufuneki uzisebenzise njengeyona ndlela yakho yolawulo lokuzalwa ngexesha lonyango lwakho. Kuya kufuneka usebenzise indlela ethembekileyo engeyohomoni yolawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango kunye nakwiveki e-1 emva kwethamo lakho lokugqibela. Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-elagolix, i-estradiol, kunye ne-norethindrone, tsalela ugqirha ngokukhawuleza. I-Elagolix, i-estradiol, kunye ne-norethindrone inokulimaza umbungu.
• Kuya kufuneka uyazi ukuba impilo yakho yengqondo inokutshintsha ngeendlela ezingalindelekanga kwaye ungazibulala (ucinga ngokuzenzakalisa okanye ukuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo) ngelixa uthatha elagolix, estradiol, kunye norethindrone. Wena, usapho lwakho, okanye umntu omkhathalelayo kufuneka ubize ugqirha wakho ngoko nangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: kukucaphuka okutsha okanye okuba mandundu, ixhala, okanye uxinzelelo; ukuthetha okanye ukucinga ngokufuna ukuzenzakalisa okanye ukuzibulala; Ukurhoxa kubahlobo nakusapho; ukuxakeka kukufa nokufa; okanye naluphi na olunye utshintsho olungaqhelekanga kwindlela oziphethe ngayo okanye kwimood. Qiniseka ukuba usapho lwakho okanye umntu okhathalelayo uyazi ukuba zeziphi iimpawu ezinokuba nobuzaza ukuze babize ugqirha ukuba awukwazi ukuzifunela unyango ngokwakho.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-4 ukusukela kwidosi yakho yokugqibela, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Elagolix, i-estradiol, kunye ne-norethindrone zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukulahleka kweenwele okanye ukunciphisa iinwele
• ukutshisa okutshisayo (ukutshitshiswa ngokukhawuleza kobushushu obushushu okanye obukhulu bomzimba)
• utshintsho kwixesha lokuya esikhathini (ukuphuma ngokungaqhelekanga okanye ukubonwa, ukuphuma kancinci okanye ukungabikho kwegazi, ukunciphisa ubude bamaxesha)
• intloko ebuhlungu
• ukutyeba kwakho
• intlungu edibeneyo
• utshintsho kwiminqweno yesini
• Ukozela okanye ukudinwa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• mthubi ulusu okanye amehlo
• ukugruzuka okanye ukopha okungaqhelekanga
• Ukuphelelwa ngumdla wokutya
• ukudinwa kakhulu, ubuthathaka, okanye ukungabikho kwamandla
• umchamo omnyama-mnyama
• isitulo esikhanyayo
• iintlungu kwinxalenye ephezulu yesisu
• isicaphucaphu
• ukugabha
• ukudumba kwezandla, iinyawo, okanye imilenze esezantsi

Umdibaniso we-elagolix, i-estradiol, kunye ne-norethindrone zinokubangela okanye zenze mandundu i-osteoporosis. Ingabunciphisa ubuninzi bamathambo akho kwaye inyuse nethuba lokophuka kwamathambo kunye nokwaphuka. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Elagolix, i-estradiol, kunye ne-norethindrone zinokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• isicaphucaphu
• ukugabha
• ukuthamba kwebele
• intlungu zesisu
• Ukozela okanye ukudinwa
• ukopha kwilungu lobufazi

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-elagolix, estradiol, kunye ne-norethindrone.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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