Inaliti ye-Idecabtagene Vicleucel

Umxholo

• Phambi kokuba ufumane inaliti ye-idecabtagene vicleucel,
• Idecabtagene vicleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Idecabtagene vicleucel inokubangela ukusabela okunobungozi okanye okusongela ubomi okubizwa ngokuba yi-cytokine release syndrome (CRS). Ugqirha okanye umongikazi uya kukujonga ngononophelo ngexesha lokufakwa kwakho kunye ubuncinci iiveki ezi-4 emva koko. Tshela ugqirha wakho ukuba unesifo esivuthayo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Uya kunikwa amayeza kwimizuzu engama-30 ukuya kwengama-60 ngaphambi kokufakwa kwakho ukunceda ukuthintela iimpendulo kwi-idecabtagene vicleucel. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ngexesha nasemva kokufakwa, xelela ugqirha ngoko nangoko: umkhuhlane, ukugodola, ukukhawuleza kwentliziyo okanye ukubetha kwentliziyo, iintlungu zemisipha, ukungcangcazela, urhudo, ukudinwa, ukuba buthathaka, ukuphefumla nzima, ukuphefumla kancinci, ukukhohlela, ukudideka, isicaphucaphu, ukugabha, isiyezi, okanye iintloko.

Inaliti ye-Idecabtagene vicleucel inokubangela ukusabela okubukhali okanye okusongela ubomi. Ezi mpendulo zinokwenzeka emva konyango nge-idecabtagene vicleucel. Tshela ugqirha wakho ukuba ukhe waxhuzula, wabethwa yistroke, okanye waphulukana nenkumbulo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: intloko ebuhlungu, isiyezi, ubunzima bokulala okanye ukulala, ukungazinzi, ukudideka, ixhala, ukungcangcazela okungalawulekiyo komzimba, ukulahleka kwengqondo, ukuphazamiseka, ukuxhuzula, ukulahleka ukulinganisela, okanye ubunzima bokuthetha.

Inaliti ye-Idecabtagene vicleucel inokubangela ukwehla okukhulu kwinani leentlobo ezithile zeeseli zegazi egazini lakho. Oku kunokubangela iimpawu ezithile kwaye kunokunyusa umngcipheko wokuba ube nosulelo olubi okanye ukopha. Ukuba unazo naziphi na kwezi mpawu zilandelayo emva konyango lwakho, xelela ugqirha ngoko nangoko: umkhuhlane, ukudinwa, okanye ukrunekile okanye ukopha.

Idecabtagene vicleucel ifumaneka kuphela kwinkqubo ekhethekileyo yokuhambisa. Inkqubo ye-Abecma REMS (uVavanyo loMngcipheko kunye neNkqubo yokuNciphisa) isekwe ngenxa yomngcipheko weCRS, inkqubo ye-nervous system kunye neengxaki zeeseli zegazi. Unokufumana amayeza kugqirha nakwiziko lokhathalelo lwempilo oluthatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nale nkqubo.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-idecabtagene vicleucel kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Inaliti ye-Idecabtagene vicleucel isetyenziselwa ukunyanga iintlobo ezithile ze-myeloma (uhlobo lomhlaza womongo wethambo) kubantu abadala abanomhlaza obuyileyo okanye ongaphenduliyo kwezinye iindlela zonyango ezine. Inaliti ye-Idecabtagene vicleucel ikudidi lwamayeza abizwa ngokuba yi-autologous cellular immunotherapy, uhlobo lonyango olulungiselelwe kusetyenziswa iiseli ezivela kwigazi lesigulana. Isebenza ngokubangela amajoni omzimba (iqela leeseli, izicwili, kunye namalungu akhusela umzimba ekuhlaselweni ziintsholongwane, iintsholongwane, iiseli zomhlaza, kunye nezinye izinto ezibangela izifo) ukuba zilwe neeseli zomhlaza.

Inaliti ye-Idecabtagene vicleucel iza njengokumiswa (ulwelo) ukuze kufakwe ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi kagqirha okanye kwiziko lokumnika. Ihlala inikwa ngaphezulu kwexesha elipheleleyo ukuya kuthi ga kwimizuzu engama-30 njengedosi yexesha elinye. Ngaphambi kokuba ufumane idosi yakho ye-idecabtagene vicleucel, ugqirha wakho okanye umongikazi uya kulawula amanye amayeza e-chemotherapy ukulungiselela umzimba wakho ukuba ulungele i-idecabtagene vicleucel.

Phambi kokuba unikwe inaliti ye-idecabtagene vicleucel inaliti, isampuli yeeseli zakho ezimhlophe zegazi ziya kuthathwa kwiziko lokuqokelela iiseli kusetyenziswa inkqubo ebizwa ngokuba yileukapheresis (inkqubo esusa iiseli ezimhlophe zegazi emzimbeni). Ngenxa yokuba eli yeza lenziwa kwiiseli zakho, kufuneka unikwe wena kuphela. Kubalulekile ukuba ufike ngexesha kwaye ungaphoswa kukuqokelelwa (okanye) kokuqokelelwa kweeselfowuni okanye ukufumana idosi yonyango. Kuya kufuneka ucwangcise ukuhlala ngaphakathi kwiiyure ezimbini zendawo apho ufumene unyango lwe-idecabtagene vicleucel unyango ubuncinci iiveki ezi-4 emva kwedosi yakho. Umboneleli wakho wezononophelo lwempilo uya kujonga ukuba unyango lwakho luyasebenza na kwaye akubeke esweni naziphi na iziphumo ebezingalindelekanga ezinokubakho. Thetha nogqirha wakho malunga nendlela yokulungiselela i-leukapheresis kunye nento onokuyilindela ngexesha nasemva kwenkqubo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokuba ufumane inaliti ye-idecabtagene vicleucel,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-idecabtagene vicleucel, nawaphi na amanye amayeza, i-dimethyl sulfoxide (DMSO), okanye nasiphi na isithako se-idecabtagene vicleucel injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-steroids ezinje nge-dexamethasone, methylprednisolone (Medrol), prednisolone, kunye ne-prednisone (iRayos). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba wakhe wanokuphendula kunyango lwe-chemotherapy lwangaphambili olunjengeengxaki zokuphefumla okanye ukubetha kwentliziyo okungaqhelekanga. Kwakhona xelela ugqirha wakho ukuba unomphunga, izintso, intliziyo, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Uya kudinga kuvavanyo lokukhulelwa ngaphambi kokuba uqale idecabtagene vicleucel. Ukuba ukhulelwa ngelixa ufumana i-idecabtagene vicleucel, tsalela umnxeba kwangoko. Idecabtagene vicleucel inokwenzakalisa umntwana ongekazalwa.
• Kuya kufuneka uyazi ukuba inaliti ye-idecabtagene vicleucel inokukwenza wozele kwaye ubangele ukudideka, ubuthathaka, isiyezi, ukuxhuzula, kunye neengxaki zokulungelelanisa. Sukuqhuba imoto okanye usebenzise oomatshini ubuncinci iiveki ezisi-8 emva kwethamo lakho le-idecabtagene vicleucel.
• musa ukunikela ngegazi, amalungu, izicwili, okanye iiseli zokufakelwa emva kokuba ufumene inaliti ye-idecabtagene vicleucel.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Awunalo naluphi na ugonyo ngaphandle kokuthetha nogqirha wakho ubuncinci iiveki ezi-6 ngaphambi kokuqala ichemotherapy, ngexesha lonyango lwe-idecabtagene vicleucel, de ugqirha akuxelele ukuba amajoni akho omzimba abuyile.

Ukuba uphosa ixesha lokuqokelela iiseli zakho, kuya kufuneka ubize ugqirha wakho kunye neziko lokuqokelela kwangoko. Ukuba uyaphoswa kukuqeshwa ukuze ufumane idosi yakho ye-idecabtagene vicleucel, kufuneka ubize ugqirha ngoko nangoko.

Idecabtagene vicleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• ukuhla ukusinda
• Ukuphelelwa ngumdla wokutya
• iintlungu zomlomo
• umlomo owomileyo
• amehlo owomileyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• Ukuncipha kokuchama rhoqo okanye isixa
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, umqala, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• kunzima ukugwinya
• irhashalala
• urhwebo
• ukurhawuzelela

Idecabtagene vicleucel inokunyusa umngcipheko wokukhula komhlaza othile. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

Idecabtagene vicleucel inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho, indawo yokuqokelela iiseli, kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-idecabtagene vicleucel injection.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba ufumana idecabtagene vicleucel. Eli yeza linokuchaphazela iziphumo zovavanyo oluthile lwelabhoratri.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-idecabtagene vicleucel.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Abecma^®