Umbhali: Virginia Floyd
Umhla Wokudalwa: 14 Eyethupha 2021
Hlaziya Umhla: 13 Eyenkanga 2024
Anonim
Anticancer Drugs (Part 5): Pharmacology of Mercaptopurine, Thioguanine, and Fluorouracil
Ividiyo: Anticancer Drugs (Part 5): Pharmacology of Mercaptopurine, Thioguanine, and Fluorouracil

Umxholo

I-Thioguanine isetyenziselwa ukunyanga i-myeloid leukemia (AML; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi).I-Thioguanine ikudidi lwamayeza abizwa ngokuba zii-analogine ze-purine. Isebenza ngokunciphisa okanye ukumisa ukukhula kweeseli zomhlaza emzimbeni wakho.

I-Thioguanine iza njengecwecwe lokuthatha ngomlomo rhoqo kube kanye ngemini. Ubude bonyango buxhomekeke kwiintlobo zamachiza owathathayo, ukuba umzimba wakho uphendula njani kuwo, kunye nohlobo lomhlaza onawo. Thatha i-thioguanine ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha thioguanine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokunyusa okanye anciphise idosi yakho ye-thioguanine ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye nakwiziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-thioguanine nokuba uziva uphilile. Sukuyeka ukuthatha thioguanine ngaphandle kokuthetha nogqirha wakho


Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-thioguanine,

  • xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-thioguanine, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-thioguanine. Buza usokhemesti wakho uluhlu lwezithako.
  • xelela ugqirha wakho ukuba sele uthathe i-thioguanine okanye i-mercaptopurine ukunyanga umhlaza wakho. Ugqirha wakho unokukuxelela ukuba ungathathi i-thioguanine ukuba elinye lala mayeza belingasebenzi kakuhle kumhlaza wakho ngaphambili.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: ii-aminosalicylates ezinje nge-mesalamine (Apriso, Asacol, Pentasa, ezinye), olsalazine (Dipentum), kunye ne-sulfasalazine (Azulfidine). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Xelela ugqirha wakho kunye nosokhemesti malunga nawo onke amayeza owathathayo ukuze bajonge ukuba ngaba nawaphi na amayeza akho anokuwonyusa umngcipheko wokuba uya kukhula ukonakala kwesibindi ngexesha lonyango lwakho nge thioguanine.
  • xelela ugqirha wakho ukuba ukhe unesifo sesibindi.
  • xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Akufanele ukhulelwe okanye uncancise ngelixa ufumana i-thioguanine. Ukuba ukhulelwe ngelixa ufumana i-thioguanine, tsalela ugqirha wakho. I-Thioguanine inokulimaza umbungu.
  • awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.
  • Kuya kufuneka uyazi ukuba umngcipheko wokuba uza kuba neziphumo ebezingalindelekanga ze-thioguanine unokuphakama xa unemfuza. Ugqirha wakho unoku-odola uvavanyo ngaphambi okanye ngexesha lonyango lwakho ukuze abone ukuba unalo mngcipheko.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Phuza ulwelo oluninzi ngexesha lonyango lwe-thioguanine.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Thioguanine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukugabha
  • ukuphelelwa ngumdla wokutya okanye ubunzima
  • izilonda emlonyeni nasemqaleni
  • intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

  • ukudinwa okungaqhelekanga okanye ubuthathaka
  • ukopha okungaqhelekanga okanye ukugruzuka
  • mthubi ulusu okanye amehlo
  • Iimpawu ezinjengomkhuhlane
  • ukudumba kwesisu
  • isisu esibuhlungu, ngakumbi kwindawo elungileyo yesisu
  • ukudumba kobuso, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
  • ukugabha okunegazi
  • emnyama, ilindle okanye ilindle eligazi
  • umkhuhlane, umqala obuhlungu, ukukhohlela nokuxinana okuqhubekayo, okanye ezinye iimpawu zosulelo
  • ukuqhawukelwa ngumphefumlo
  • intloko elula

I-Thioguanine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.


Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

  • isicaphucaphu
  • ukugabha
  • ukubila okugqithisileyo
  • ukudinwa okungaqhelekanga okanye ubuthathaka
  • ukopha okungaqhelekanga okanye ukugruzuka
  • umkhuhlane, umqala obuhlungu, ukukhohlela nokuxinana okuqhubekayo, okanye ezinye iimpawu zosulelo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-thioguanine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • Itheyibhile®
  • 2-Amino-6-mercaptopurine
  • I kZ
  • 6-Thioguanine
Ukuhlaziywa kokugqibela-05/15/2017

Ukukhetha Kwabafundi

Intlungu yentamo: Izizathu eziphambili ze-8 kunye nendlela yokunyanga

Intlungu yentamo: Izizathu eziphambili ze-8 kunye nendlela yokunyanga

Intlungu yentamo ihlala ingelo phawu lwengxaki enkulu, ixhaphake kakhulu kwimeko zoxinzelelo olugqithi ileyo, ezibangelwa ziimeko ezinje ngoxinzelelo lweemvakalelo, uxinzelelo lwegazi okanye uxinzelel...
Izifo ezi-7 eziphathwe kukhuthazo olunzulu lobuchopho

Izifo ezi-7 eziphathwe kukhuthazo olunzulu lobuchopho

Ukuvu elelwa kwengqondo okunzulu, okwaziwa ngokuba yi-cerebral pacemaker okanye i-DB , Ukukhuthaza Ubunzulu beBongo, yinkqubo yotyando apho kufakelwa i-electrode encinci ukukhuthaza imimandla ethile y...