Umbhali: Joan Hall
Umhla Wokudalwa: 6 Eyomdumba 2021
Hlaziya Umhla: 24 Eyenkanga 2024
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Anti malarial drugs - Quinine ( Pharmacology by Dr Rajesh Gubba )
Ividiyo: Anti malarial drugs - Quinine ( Pharmacology by Dr Rajesh Gubba )

Umxholo

I-quinine akufuneki isetyenziselwe ukunyanga okanye ukuthintela iinyikima zomlenze ebusuku. I-Quinine ayiboniswanga ukuba iyasebenza kule njongo, kwaye inokubangela iziphumo ezibi okanye ezisongela ubomi, kubandakanya iingxaki zokopha kakhulu, ukonzakala kwezintso, ukubetha kwentliziyo ngendlela engaqhelekanga, kunye neempendulo ezimbi.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-quinine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Iquinine isetyenziswa yodwa okanye namanye amayeza ukunyanga isifo seengcongconi (isifo esibi okanye esisongela ubomi esisasazwa ziingcongconi kwiindawo ezithile zehlabathi). I-quinine akufuneki isetyenziselwe ukukhusela isifo seengcongconi. UQuinine ukwiklasi yamayeza ebizwa ngokuba zii-antimalarials. Isebenza ngokubulala izinto ezibanga isifo seengcongconi.


IQuinine iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa ngokutya kathathu ngemini (qho iiyure ezisi-8) kangangeentsuku ezi-3 ukuya kwezi-7. Thatha iquinine ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha iquinine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze. IQuinine inencasa ekrakra.

Kuya kufuneka uqale uzive ungcono ngeentsuku zokuqala eziyi-1-2 zonyango lwakho. Biza ugqirha wakho ukuba iimpawu zakho aziphuculanga okanye ukuba ziya zisiba mbi. Fowunela ugqirha wakho ukuba unefiva emva nje kokuba ulugqibile unyango lwakho. Oku kunokuba ngumqondiso wokuba ufumana isiqendu sesibini se-malaria.

Thatha iquinine de ugqibe amayeza, nokuba uziva ungcono. Ukuba uyeka ukuthatha i-quinine kwakamsinya okanye ukuba ungatsiba idosi, usulelo lwakho alunakuphathwa kwaphela kwaye izinto eziphilayo zinokumelana ne-antimalarials.


Iquinine ngamanye amaxesha isetyenziselwa ukunyanga i-babesiosis (isifo esibi okanye esisongela ubomi esidluliselwa sisuka kwizilwanyana siye ebantwini ngamakhalane). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe iquinine,

  • xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa iquinine, quinidine, mefloquine (Lariam), nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsules zequinine. Buza ugqirha wakho okanye usokhemesti uluhlu lwezithako.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: acetazolamide (Diamox); aminophylline; ii-anticoagulants ('igazi elincinci') njenge-warfarin (Coumadin) kunye neherparin; i-anti-depressants (’mood elevators’) ezinjenge desipramine; izinto ezithile zokubulala ukungunda ezifana ne-fluconazole (Diflucan), ketoconazole (Nizoral), kunye ne-itraconazole (Sporanox); cholesterol-ukunciphisa amayeza afana ne-atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor); i-cisapride (iPropulsid); dextromethorphan (iyeza kwiimveliso ezininzi zokukhohlela); i-fluoroquinolone antibiotics njenge-ciprofloxacin (Cipro), gatifloxacin (Tequin) (ayifumaneki e-US), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (ofloxacin) ) (ayifumaneki e-US); ii-macrolide antibiotics ezifana ne-erythromycin (EES, E-Mycin, Erythrocin) kunye ne-troleandomycin (ayifumaneki e-US); amayeza seswekile ezifana repaglinide (Prandin); amayeza kuxinzelelo lwegazi; amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), dofetilide (Tikosyn), flecainide (Tambocor), procainamide (Procanbid, Pronestyl), quinidine, kunye ne-sotalol (Betapace); amayeza athile okubanjwa njenge-carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), kunye ne-phenytoin (Dilantin); amayeza kwizilonda ezinje nge-cimetidine (Tagamet); i-mefloquine (iLariam); iMetoprolol (iLopressor, iTrolrol XL); iPaclitaxel (Abraxane, iTaxol); ipimozide (Orap); irifampin (Rifadin, Rimactane); ezithile ezikhethiweyo ze-serotonin reuptake inhibitors (ii-SSRIs) ezinjenge-fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), kunye ne-paroxetine (Paxil); isodium bicarbonate; itetracycline; kunye ne-theophylline. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana nequinine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
  • musa ukuthatha ii-antacids eziqulethe i-magnesium okanye i-aluminium (i-Alternagel, i-Amphogel, i-Alu-cap, i-Alu-tab, iBasaljel, iGaviscon, i-Maalox, i-Milk yaseMagnesia, okanye i-Mylanta) ngaxeshanye uthatha i-quinine. malunga nokuba ulinde ixesha elingakanani phakathi kokuthatha olu hlobo lwe-antacid kunye nokuthatha i-quinine.
  • xelela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho unethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukuba utyhafe okanye ukubetha kwentliziyo ngokungaqhelekanga), i-electrocardiogram engaqhelekanga (i-ECG; uvavanyo olulinganisa umsebenzi wombane wentliziyo) , kwaye ukuba unayo okanye wakha wanesiphene se-G-6-PD (isifo esifa njengelifa), okanye ukuba une-myasthenia gravis (MG; imeko ebangela ubuthathaka bemisipha ethile), okanye i-optic neuritis (ukudumba luvo lwe-optic olunokubangela utshintsho olukhawulezileyo kumbono). Xelela ugqirha wakho ukuba wakhe waphendula ngokunzulu, ngakumbi ingxaki yokopha okanye iingxaki ngegazi lakho emva kokuba uthathe iquinine ngaphambili. Ugqirha wakho uya kukuxelela ukuba ungathathi i-quinine.
  • xelela ugqirha wakho ukuba ukhe wabethwa yintliziyo kancinci okanye engaqhelekanga; amanqanaba asezantsi e-potassium egazini lakho; okanye intliziyo, isifo, okanye isifo sesibindi.
  • xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-quinine, tsalela ugqirha wakho.
  • ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-quinine.
  • xelela ugqirha wakho ukuba usebenzisa iimveliso zecuba. Ukutshaya icuba kunokunciphisa ukusebenza kweli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba bekungaphezulu kweeyure ezingama-4 ukusukela ngexesha ekufanele ukuba uthathe idosi ephosiweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Eli yeza linokubangela iswekile esezantsi yegazi. Kuya kufuneka uyazi iimpawu zeswekile esezantsi yegazi kunye nokuba wenzeni ukuba uphuhlisa ezi mpawu.

IQuinine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukungazinzi
  • ubunzima bokuva okanye ukukhala ezindlebeni
  • ukudideka
  • uvalo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko:

  • irhashalala
  • urhwebo
  • ukurhawuzelela
  • ukugungxula
  • ukudinwa
  • ubunzima bokuphefumla okanye ukugwinya
  • ukudumba kobuso, umqala, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
  • ifiva
  • amadyungudyungu
  • isisu esibuhlungu
  • ukugabha
  • urhudo
  • ukufiphala okanye utshintsho kumbono wombala
  • ukungakwazi ukuva okanye ukubona
  • ukudinwa
  • ukutyunyuzwa ngokulula
  • mfusa, mdaka, okanye amabala abomvu kulusu
  • ukopha okungaqhelekanga
  • igazi kumchamo
  • isitulo esimnyama okanye sokulinda
  • impumlo
  • iintsini ezophayo
  • umqala obuhkungu
  • ukukhawuleza kwentliziyo okanye okungaqhelekanga
  • iintlungu zesifuba
  • ubuthathaka
  • ukubila
  • isiyezi

I-Quinine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Sukuyifaka efrijini okanye uyibandeze iyeza.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo.Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

  • ukufiphala okanye utshintsho kumbono wombala
  • iimpawu zeswekile esezantsi yegazi
  • utshintsho kwintliziyo
  • intloko ebuhlungu
  • isicaphucaphu
  • ukugabha
  • isisu esibuhlungu
  • urhudo
  • ukukhala ezindlebeni okanye ukuva ubunzima
  • ukuxhuzula
  • ukuphefumla kancinci okanye nzima

Gcina lonke ixesha lokudibana nogqirha wakho.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha iquinine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • IQuququin®
Ukuhlaziywa kokugqibela-06/15/2017

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