Ketoconazole

Umxholo

• Ngaphambi kokuba uthathe i-ketoconazole,
• I-Ketoconazole inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Ketoconazole kufuneka isetyenziselwe kuphela ukunyanga usulelo lomngundo xa amanye amayeza engafumaneki okanye engenakunyamezeleka.

I-Ketoconazole inokubangela ukulimala kwesibindi, ngamanye amaxesha inzulu ngokwaneleyo ukuba ifune ukufakelwa kwesibindi okanye ukubangela ukufa. Ukonakala kwesibindi kunokwenzeka kubantu abangenaso isifo sesibindi okanye naziphi na ezinye iimeko ezonyusa umngcipheko wokuba baya kuba nomonakalo wesibindi. Xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala kwaye ukuba ukhe unesifo sesibindi. Musa ukusela nasiphi na isiselo esinxilisayo ngexesha lokunyanga nge-ketoconazole kuba ukusela iziselo ezinxilisayo kunokunyusa umngcipheko wokuba ube nomonakalo wesibindi.Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukudinwa kakhulu, ukuncipha kokutya, ukuncipha, isicaphucaphu, ukugabha, ukutyheli kolusu okanye amehlo, umchamo omnyama omthubi, isitulo esimthubi, iintlungu kwinxalenye ephezulu yasekunene isisu, umkhuhlane, okanye irhashalala.

I-Ketoconazole inokubangela ukwanda kwe-QT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ukuphulukana nokuqonda, ukuxhuzula, okanye ukufa ngesiquphe). Musa ukuthatha i-disopyramide (i-Norpace), i-dofetilide (Tikosyn), i-dronedarone (i-Multaq), i-pimozide (i-Orap), i-quinidine (i-Quinidex, i-Quinaglute), i-cisapride (i-Propulsid; ayisekho e-US), i-methadone (i-Dolophine, i-Methadose) kunye ranolazine (Ranexa) ngelixa uthatha i-ketoconazole. Ukuba unazo naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-ketoconazole kwaye ubize ugqirha ngoko nangoko: ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga; isiqaqa; isiyezi; intloko emhlophe; okanye ukulahleka kwengqondo.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-ketoconazole.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ketoconazole kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-ketoconazole.

I-Ketoconazole isetyenziselwa ukunyanga usulelo lomngundo xa amanye amayeza engafumaneki okanye engenakunyamezeleka. I-Ketoconazole akufuneki isetyenziselwe ukunyanga i-fungal meningitis (usulelo lwembrane ejikeleze ingqondo kunye nentambo yomqolo ebangelwa ngundo) okanye usuleleko lwefungal. I-Ketoconazole ikwiklasi ye-antifungals ebizwa ngokuba ziimidazoles. Isebenza ngokunciphisa ukukhula komngundo obangela usulelo.

I-Ketoconazole iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini Thatha i-ketoconazole ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ketoconazole ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokunyusa idosi yakho ukuba imeko yakho ayiphucuki.

Kuya kufuneka uthathe i-ketoconazole iinyanga ezi-6 okanye ngaphezulu ukunyanga usulelo lwakho ngokupheleleyo. Qhubeka uthathe i-ketoconazole de ugqirha akuxelele ukuba uyeke, nokuba uziva ngcono. Ungayeki ukuthatha i-ketoconazole ngaphandle kokuthetha nogqirha wakho. Ukuba uyeka ukuthatha i-ketoconazole kwakamsinya, usulelo lwakho lunokubuya emva kwexesha elifutshane.

Amanqanaba aphezulu e-ketoconazole ngamanye amaxesha asetyenziselwa ukunyanga i-Cushing syndrome (imeko eyenzeka xa kukho i-hormone ye-corticosteroid eninzi emzimbeni) kunye nomhlaza wedlala lobudoda (umhlaza wedlala lokuzala). I-Ketoconazole ayiboniswanga ukuba ikhuselekile okanye ayisebenzi kwezi zinto zisetyenziswayo. Thetha nogqirha wakho malunga nokusebenzisa i-ketoconazole kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ketoconazole,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-ketoconazole okanye nawaphi na amanye amayeza okanye ezinye izithako kwiipilisi ze-ketoconazole. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-alprazolam (Niravam, Xanax); eplerenone (Inspra); I-ergot alkaloids ezinjenge-ergotamine (i-Ergomar, eCafergot, eMigergot), i-dihydroergotamine (i-DHE 45, iMigranal), kunye ne-methylergonovine (Methergine); felodipine (Plendil); irinotecan (Camptosar); I-lovastatin (Mevacor); ilurasidone (iLatuda); midazolam (iVesi); i-nisoldipine (iSular); isimvastatin (iZocor); iTolvaptan (iSamsca); kunye netriazolam (Halcion). Ugqirha wakho uya kukuxelela ukuba ungathathi i-ketoconazole ukuba uthatha elinye okanye ngaphezulu kwala mayeza okanye nawaphi na amayeza adweliswe kwicandelo LESILumkiso ESIBALULEKILEYO.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo. Qinisekisa ukukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zinto zilandelayo: aliskiren (Tekturna, eValturna, eAmturnide); i-anticoagulants ('igazi elincinci') njenge-dabigatran (Pradaxa), i-rivaroxaban powder (i-Xarelto) kunye ne-warfarin (i-Coumadin); Aprepitant (Hlomela); aripiprazole (Yenza); atorvastatin (Lipitor); i-bosentan (iTracleer); budesonide (Uceris); buspirone (BuSpar); carbamazepine (Tegretol); iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), nifedipine (Adalat, Procardia), kunye verapamil (Calan, Covera, Isoptin, Verelan); amayeza omhlaza afana ne-bortezomib (Velcade); busulfan (Myleran); dasatinib (Sprycel); I-docetaxel (iTaxotere), i-erlotinib (iTarceva); ixabepilone (Ixempra); lapatinib (iTykerb); nilotinib (Tasigna); paclitaxel (Taxol), trimetrexate (Neutrexin), vincristine (Vincasar), vinblastine, kunye vinorelbine (Navelbine); iciclesonide (Alvesco); Iililostazol (Pletal); cinacalcet (iSensipar); icolchicine (Colcrys, kwiCol-Probenecid); dexamethasone; idigoxin (Lanoxin); i-eletriptan (i-Relpax); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis); ifesoterodine (Toviaz); ifluticasone (Flonase, Flovent); haloperidol (iHaldol); Amayeza e-HIV anje nge darunavir (Prezista), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), maraviroc (Selzentry), nevirapine (Viramune), ritonavir (Norvir), kunye ne saquinavir (Invirase, Fortovase); ii-immunosuppressants ezinje ngecyclosporine (Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), kunye ne-tacrolimus (Prograf); imatinib (Gleevec); amayeza e-erectile dysfunction njenge-sildenafil (Viagra), tadalafil (Cialis), kunye ne-vardenafil (Levitra); amayeza okugaya isisu, ukutsha kwentliziyo, okanye izilonda ezinje nge-cimetidine (Tagamet), famotidine (Pepcid), lansoprazole (Prevacid), nizatidine (Axid), omeprazole (Prilosec), kunye ne-ranitidine (iZantac); amayeza okunyanga isifo sephepha njenge-isoniazid (INH, Nydrazid), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane); imethylprednisolone (iMedrol); u-nadolol (uCorgard); i-oxycodone (i-Oxecta, i-Oxy Contin, kwiPercocet, ezinye); phenytoin (Dilantin); ipraziquantel (iBiltricide); iquetiapine (iSeroquel); i-ramelteon (iRozerem); repaglinide (Prandin, kwiPrandiMet); irisperidone (iRisperdal); isalmeterol (iSerevent, eAdvair); isaxagliptin (iOnglyza); i-solifenacin (Vesicare); ii-immunosuppressants ezinje ngecyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), kunye ne-tacrolimus (Prograf); tamsulosin (Flomax, eJalyn); telithromycin (Ketek); kunye ne-tolterodine (Detrol). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-ketoconazole, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha i-antacid ene-aluminium, calcium, okanye i-magnesium (Maalox, Mylanta, Tums, others), yithathe iyure e-1 ngaphambi okanye kwiiyure ezimbini emva kokuba uthathe i-ketoconazole.
• xelela ugqirha wakho ukuba ukhe wakha wanemiqathango ekhankanyiweyo kwicandelo LESILUMKISO ESIBALULEKILEYO okanye ukungoneliseki kwe-adrenal (imeko apho amadlala eadrenal engenzi ngokwaneleyo iihomoni ze-steroid).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-ketoconazole, biza ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ketoconazole.
• Kuya kufuneka uyazi ukuba ukusela iziselo ezinxilisayo (kubandakanya iwayini, ibhiya, kunye namayeza aqukethe utywala njengesiraphu sokukhohlela) ngelixa uthatha i-ketoconazole yonyusa umngcipheko wokuba ube nomonakalo wesibindi kwaye unokubangela iimpawu ezingathandekiyo njengokugungxula, irhashalala, isicaphucaphu, intloko nokudumba kwezandla, iinyawo, amaqatha, okanye imilenze esezantsi xa usela utywala ngelixa uthatha i-ketoconazole.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ketoconazole inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• isisu esibuhlungu
• urhudo
• ukuqhina
• isilungulela
• irhasi
• utshintsho kwisakhono sokungcamla ukutya
• umlomo owomileyo
• utshintsho kumbala wolwimi
• ubunzima bokulala okanye ukulala
• uvalo
• Ukuba ndindisholo, ukutshisa, okanye ukubetha kwezandla okanye kweenyawo
• iintlungu zemisipha
• ukulahleka kweenwele
• ukugungxula
• Ukugodola
• uvakalelo ekukhanyeni
• impumlo
• ukwandiswa kwamabele emadodeni
• ukwehla kwesini

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• irhashalala
• urhwebo
• ukurhawuzelela
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa
• ubunzima bokuphefumla okanye ukugwinya
• ukudinwa okanye ubuthathaka

I-Ketoconazole inokubangela ukwehla kwenani lesidoda (iiseli zamadoda zokuzala) ezivelisiweyo, ngakumbi ukuba zithathwa ngeedosi eziphezulu. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza ukuba uyindoda kwaye ungathanda ukuba nabantwana.

I-Ketoconazole inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-ketoconazole.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho ukuba unemibuzo malunga nokuzalisa amayeza akho. Ukuba usenempawu zosulelo emva kokugqiba i-ketoconazole, tsalela ugqirha wakho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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