IClozapine

Umxholo

• Ngaphambi kokuba uthathe i-clozapine,
• I-Clozapine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe KUMANQAKU OKUBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, tsalela ugqirha ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Clozapine inokubangela imeko egazini. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi kokuba uqale unyango lwakho, ngexesha lonyango lwakho, kwaye ubuncinci iiveki ezi-4 emva konyango lwakho. Ugqirha wakho uya kuyalela uvavanyo lwelebhu kube kanye ngeveki ekuqaleni kwaye angayalela ukuba kuvavanywe amaxesha ngamaxesha njengoko unyango lwakho luqhubeka. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukudinwa kakhulu; ubuthathaka; umkhuhlane, umqala obuhlungu, ukugodola, okanye ezinye iimpawu zomkhuhlane okanye usulelo; ukubhobhoza engaqhelekanga okanye ukurhawuzelela; izilonda emlonyeni okanye emqaleni; amanxeba athabatha ixesha elide ukuphola; intlungu okanye ukutshisa xa uchama; izilonda okanye iintlungu ngaphakathi okanye kwindawo ejikeleze indawo yakho yomqala; okanye iintlungu zesisu.

Ngenxa yomngcipheko ngeli chiza, i-clozapine ifumaneka kuphela kwinkqubo ekhethekileyo yokuhambisa. Inkqubo isekiwe ngabavelisi be-clozapine ukuqinisekisa ukuba abantu abayithathi i-clozapine ngaphandle kohlolo oluyimfuneko olubizwa ngokuba yiNkqubo yeClozapine Risk Evaluation and Mitigation Strategies (REMS). Ugqirha wakho kunye nosokhemesti wakho kufuneka babhaliswe kwinkqubo yeClozapine REMS, kwaye usokhemesti wakho akazukukunika amayeza ngaphandle kokuba ufumene iziphumo zovavanyo lwegazi. Buza ugqirha wakho ngolwazi oluthe kratya malunga nale nkqubo kunye nendlela oza kuwafumana ngayo amayeza akho.

I-Clozapine inokubangela ukuxhuzula. Tshela ugqirha wakho ukuba ukhe waxhuzula. Musa ukuqhuba imoto, sebenzisa oomatshini, ukuqubha, okanye ukunyuka ngelixa uthatha i-clozapine, kuba ukuba ngequbuliso ulahlekelwe sisazela, unokuzenzakalisa okanye wenzakalise abanye. Ukuba ufumana ukuxhamla, biza ugqirha wakho ngokukhawuleza okanye ufumane unyango lwezonyango.

I-Clozapine inokubangela i-myocarditis (ukudumba kwentliziyo yemisipha enokuba yingozi) okanye i-cardiomyopathy (eyandisiweyo okanye ejiyileyo yentliziyo emisa intliziyo ekupompeni igazi ngesiqhelo). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukudinwa kakhulu; umkhuhlane njengeempawu; ubunzima bokuphefumla okanye ukuphefumla ngokukhawuleza; ifiva; iintlungu zesifuba; okanye ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo.

I-Clozapine inokubangela ukuba ube nesiyezi, ukuba nentloko elula, okanye ukutyhafa xa usukuma, ngakumbi xa uqala ukuyithatha okanye xa idosi yakho inyukile. Tshela ugqirha wakho ukuba ukhe wahlaselwa sisifo sentliziyo, ukusilela kwentliziyo, okanye ukubetha kwentliziyo okungahambi kakuhle, okanye uthatha amayeza oxinzelelo lwegazi. Xelela ugqirha wakho ukuba uyagabha kakhulu okanye urhudo okanye iimpawu zokuphelelwa ngamanzi emzimbeni ngoku, okanye ukuba uziphuhlisa ezi mpawu nanini na ngexesha lonyango lwakho. Ugqirha wakho uya kukuqala ngedosi esezantsi ye-clozapine kwaye ngokuthe ngcembe andise idosi yakho ukuze unike umzimba wakho ixesha lokuziqhelanisa nonyango kwaye unciphise ithuba lokuba ube namava oku. Thetha nogqirha wakho ukuba awuyithathi i-clozapine kangangeentsuku ezi-2 okanye ngaphezulu. Ugqirha wakho uya kukuxelela ukuba uqalise kwakhona unyango lwakho ngeqondo eliphantsi le-clozapine.

Sebenzisa kuBantu abaDala abaDala:

Izifundo zibonise ukuba abantu abadala abanesifo sengqondo esixhalabisayo (ukuphazamiseka kwengqondo okuchaphazela amandla okukhumbula, ukucinga ngokucacileyo, ukunxibelelana, nokwenza imisebenzi yemihla ngemihla kwaye kunokubangela utshintsho kwiimvakalelo nakubuntu) abathatha ii-antipsychotic (amayeza esigulo sengqondo) njenge-clozapine banamathuba amaninzi okufa ngexesha lonyango.

I-Clozapine ayivunywanga yi-Food and Drug Administration (FDA) kunyango lweengxaki zokuziphatha kubantu abadala abanesifo sengqondo esixhalabisayo. Thetha nogqirha okumisele i-clozapine ukuba wena, ilungu losapho, okanye umntu omkhathalelayo unesifo sengqondo esixhalabisayo kwaye uthatha eli yeza. Ngolwazi oluthe kratya ndwendwela iwebhusayithi ye-FDA: http://www.fda.gov/Drugs

I-Clozapine isetyenziselwa ukunyanga iimpawu zesifo sengqondo (isifo sengqondo esibangela ukuphazamiseka okanye ukucinga okungaqhelekanga, ukuphelelwa ngumdla ebomini, kunye neemvakalelo ezinamandla okanye ezingafanelekanga) kubantu abangakhange bancedwe ngamanye amayeza okanye abaye bazama ukuzibulala kunokwenzeka ukuba bazame ukuzibulala okanye ukuzenzakalisa kwakhona. I-Clozapine ikudidi lwamayeza abizwa ngokuba yi-atypical antipsychotic. Isebenza ngokutshintsha umsebenzi wezinto ezithile zendalo kwingqondo.

I-Clozapine iza njengecwecwe, ithebhulethi eyahlayo ngomlomo (ithebhulethi inyibilika ngokukhawuleza emlonyeni), kunye nokumiswa ngomlomo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa kanye okanye kabini imihla ngemihla. Thatha i-clozapine malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-clozapine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ungazami ukutyhala ithebhulethi yokuqhekeza ngomlomo ngokupakishwa kweefoyile. Endaweni yoko, sebenzisa izandla ezomileyo ukukhupha i-foil. Khawuleza ukhuphe icwecwe kwaye ulibeke kulwimi lwakho. Ithebhulethi iya kunyibilika ngokukhawuleza kwaye ingaginywa ngamathe. Akukho manzi afunekayo okuginya iipilisi.

Ukulinganisa ukumiswa kwe-clozapine ngomlomo, landela la manyathelo:

1. Qiniseka ukuba isiciko siqinile kwisitya sokunqunyanyiswa ngomlomo ngokujika ikepusi ngokujonga ngasekunene (ngasekunene). Shake ibhotile phezulu nasezantsi kangangemizuzwana eli-10 ngaphambi kokuba uyisebenzise.
2. Susa ikepusi yebhotile ngokutyhala ezantsi kwikepusi, emva koko uyijike ngokuchaseneyo newashi (ngasekhohlo). Ngethuba lokuqala uvula ibhotile entsha, tyhala iadaptha kwibhotile ide ibe phezulu iadaptha igcwele umphezulu webhotile.
3. Ukuba idosi yakho iyi-1 ml okanye ngaphantsi, sebenzisa isirinji yomlomo encinci (1 mL). Ukuba idosi yakho ingaphezulu kwe-1 mL, sebenzisa enkulu (9 mL) yesirinji yomlomo.
4. Gcwalisa isirinji yomlomo ngomoya ngokubuyisela umva kwiplanja. Emva koko faka incam evulekileyo yesirinji yomlomo kwiadaptha. Push wonke umoya ukusuka kwisirinji yomlomo ungene kwibhotile ngokutyhala phantsi kwiplunger.
5. Ngelixa ubambe isirinji yomlomo endaweni, jika ngononophelo ibhotile ujonge ezantsi. Zoba amanye amayeza ngaphandle kwebhotile uyingenise kwisirinji yomlomo ngokutsala ubuye kwiplunger. Lumka ungakhuphi isixhobo sompompo yonke indlela yokuphuma.
6. Uya kubona isixa esincinci somoya kufutshane nesiphelo sesitshisi kwisirinji yomlomo. Push kwi-plunger ukuze iyeza libuyele ebhotileni kwaye umoya uyanyamalala. Buyela umva kwiplunger ukuze uzobe idosi yonyango oluchanekileyo kwisirinji yomlomo.
7. Ngelixa ubambe isirinji yomlomo ebhotileni, jika ngononophelo ibhotile phezulu ukuze isirinji iphezulu. Susa isirinji yomlomo kwi-adaptha yentamo yebhotile ngaphandle kokutyhala kwiplunger. Thatha iyeza kanye emva kokuba ulitsale kwisirinji yomlomo. Musa ukulungiselela idosi kwaye uyigcine kwisirinji ukuze uyisebenzise kamva.
8. Beka incam evulekileyo yesirinji yomlomo kwelinye icala lomlomo wakho. Yivale ngokuqinileyo imilebe yakho ujikeleze isirinji yomlomo uze uyityhale kancinci xa ulwelo lungena emlonyeni wakho. Ginya amayeza kancinci kancinci njengoko esiya emlonyeni wakho.
9. Shiya iadaptha kwibhotile. Beka ikepusi emva kwibhotile kwaye uyijike ngokwewotshi (ngasekunene) ukuze uyiqinise.
10. Yipule ngesirinji yomlomo ngamanzi afudumeleyo empompo emva kosebenziso ngalunye. Gcwalisa ikomityi ngamanzi uze ubeke incam yesirinji yomlomo emanzini endebeni. Phinda ubuye emva kweplanja uze uzobe amanzi kwisirinji yomlomo. Push kwi-plunger ukuze ujikeleze amanzi kwisinki okanye isitya esahlukileyo de isirinji yomlomo icoceke. Vumela isirinji yomlomo ukuba yome kwaye ulahle nayiphi na into eseleyo yokuhlamba ngamanzi.

I-Clozapine ilawula i-schizophrenia kodwa ayiyinyangi. Ingathatha iiveki ezimbalwa okanye ngaphezulu ngaphambi kokuba uzive izibonelelo ze-clozapine. Qhubeka nokuthatha i-clozapine nokuba uziva uphilile. Sukuyeka ukuthatha i-clozapine ngaphandle kokuthetha nogqirha wakho. Ugqirha wakho uya kufuna ukunciphisa umthamo wakho ngokuthe ngcembe.

Eli yeza akufuneki limiselwe ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-clozapine,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-clozapine, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-clozapine. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya abo badweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: antihistamines ezifana ne-diphenhydramine (Benadryl); ii-antibiotics ezinje nge-ciprofloxacin (Cipro) kunye ne-erythromycin (EES, E-Mycin, nabanye); benztropine (Cogentin); cimetidine (iTagamet); ibupropion (Aplenzin, Wellbutrin, Zyban, kwiContrave); cyclobenzaprine (Amrix); I-escitalopram (iLexapro); amayeza oxinzelelo, uxinzelelo oluphezulu lwegazi, ukugula ngengqondo, ukugula kwesindululo, okanye isicaphucaphu; amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-encainide, flecainide, propafenone (Rythmol), kunye nequinidine (eNuedexta); izinto zokucwangcisa ngomlomo; amayeza okubanjwa njenge-carbamazepine (i-Equetro, iTegretol, iTeril, abanye) okanye i-phenytoin (iDilantin, Phenytek); irifampin (Rifadin, Rimactane, eRifamate, eRifater); ukuthomalalisa; i-serotonin reuptake inhibitors (i-SSRIs) ekhethiweyo njenge-duloxetine (iCymbalta), i-fluoxetine (i-Prozac, i-Sarafem, i-Selfemra, abanye), i-fluvoxamine (i-Luvox), i-paroxetine (i-Brisdelle, i-Paxil, i-Pexeva) kunye ne-sertraline (i-Zoloft); iipilisi zokulala; terbinafine (ILamisil); kunye noxinzelelo. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• Ukongeza kwimeko edweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, xelela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho ukhe wanethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe) okanye isifo seswekile. Tshela ugqirha wakho ukuba unesisu, isicaphucaphu, ukugabha, okanye iintlungu zesisu okanye ukuphazamiseka; okanye ukuba unayo okanye wakha wanengxaki kwinkqubo yakho yokuchama okanye iprostate (idlala lokuzala); i-dyslipidemia (amanqanaba aphezulu e-cholesterol); ileus ekhubazekileyo (imeko apho ukutya kungenako ukuhamba emathunjini); iglaucoma; uxinzelelo lwegazi oluphezulu okanye oluphantsi; ingxaki yokugcina ibhalansi yakho; okanye isifo sentliziyo, sezintso, semiphunga okanye sesibindi. Xelela ugqirha wakho ukuba ukhe uyeke ukuthatha iyeza lokugula ngengqondo ngenxa yeziphumo ebezingalindelekanga ezibi.
• xelela ugqirha wakho ukuba ukhulelwe, ngakumbi ukuba ukwinyanga ezimbalwa ezidlulileyo zokukhulelwa kwakho, okanye ukuba ucwangcisa ukukhulelwa okanye ukuncancisa. Ukuba ukhulelwe ngelixa uthatha i-clozapine, tsalela umnxeba ugqirha wakho. I-Clozapine inokubangela iingxaki kwiintsana ezisandula ukuzalwa emva kokubeleka ukuba zithathiwe kwiinyanga zokugqibela zokukhulelwa.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-clozapine.
• Kuya kufuneka uyazi ukuba utywala bunokongeza ukozela okubangelwa leli yeza.
• xelela ugqirha wakho ukuba usebenzisa iimveliso zecuba. Ukutshaya icuba kunokunciphisa ukusebenza kweli yeza.
• Kuya kufuneka uyazi ukuba unokufumana i-hyperglycemia (inyuka kwiswekile esegazini lakho) ngelixa uthatha eli yeza, nokuba awukabinaso isifo seswekile. Ukuba une-schizophrenia, kunokwenzeka ukuba ube nesifo seswekile kunabantu abangenayo i-schizophrenia, kwaye ukuthatha i-clozapine okanye amayeza afanayo kunokuwunyusa lo mngcipheko. Xelela ugqirha wakho kwangoko ukuba unayo nayiphi na kwezi mpawu zilandelayo ngelixa uthatha i-clozapine: ukunxanwa okugqithisileyo, ukuchama rhoqo, ukulamba kakhulu, umbono ophuthileyo, okanye ubuthathaka. Kubaluleke kakhulu ukubiza ugqirha wakho nje ukuba ufumane naziphi na kwezi mpawu, kuba iswekile eninzi egazini inokubangela imeko embi ebizwa ngokuba yi ketoacidosis. I-Ketoacidosis inokuba sengozini yobomi ukuba ayinyangwa kwangoko. Iimpawu zeketoacidosis zibandakanya: umlomo owomileyo, isicaphucaphu kunye nokugabha, ukuphefumla kancinci, umphefumlo onuka iziqhamo, kunye nokwehla kwengqondo.
• ukuba une-phenylketonuria (PKU, imeko ekuyo njengelifa apho ukutya okukhethekileyo kufuneka kulandelwe ukuthintela ukudodobala kwengqondo), kuya kufuneka wazi ukuba amacwecwe odilikayo ngomlomo ane-aspartame eyenza i-phenylalanine.

Thetha nogqirha wakho malunga nokusela iziselo ezinecafine ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uyaphoswa ukuthatha i-clozapine ngaphezulu kweentsuku ezi-2, kuya kufuneka ubize ugqirha ngaphambi kokuba uthathe amanye amayeza. Ugqirha wakho unokufuna ukuqala kwakhona amayeza akho kwidosi esezantsi.

I-Clozapine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukozela
• isiyezi, ukuziva ungazinzanga, okanye unengxaki yokugcina ibhalansi yakho
• ukwanda kwamathe
• umlomo owomileyo
• ukungazinzi
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe KUMANQAKU OKUBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, tsalela ugqirha ngokukhawuleza:

• ukuqhina; isicaphucaphu; ukudumba kwesisu okanye iintlungu; okanye ukugabha
• ukuxhawula izandla ongenakuzilawula
• isiqaqa
• ukuwa
• ubunzima bokuchama okanye ukulahleka kolawulo lwesinyi
• ukudideka
• utshintsho kumbono
• ukungcangcazela
• ukuqina kwemisipha kakhulu
• ukubila
• utshintsho kwindlela yokuziphatha
• ukopha okungaqhelekanga okanye ukugruzuka
• Ukuphelelwa ngumdla wokutya
• isisu esimoshakele
• mthubi ulusu okanye amehlo
• iintlungu kwindawo ephezulu yesisu
• ukunqongophala kwamandla

I-Clozapine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya nobushushu obungaphezulu kunye nobumanzi (hayi kwigumbi lokuhlambela). Musa ukufriji okanye ubambe umkhenkce ukunqunyanyiswa ngomlomo.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isiyezi
• isiqaqa
• ukuphefumla kancinci
• utshintsho kwintliziyo
• ukulahleka kwengqondo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-clozapine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Clozaril^®
• FazaClo^® I-ODT
• IVersacloz^®