Gqibezela

Uncediso luvavanyo lwegazi olulinganisa umsebenzi weeproteni ezithile kulwelo olunegazi.

Inkqubo yokuncedisana liqela leeprotein eziphantse ezingama-60 ezikwi-plasma yegazi okanye kumphezulu weeseli ezithile. Iiproteni zisebenza kunye namajoni akho omzimba kwaye zidlala indima ukukhusela umzimba kwizifo, kunye nokususa iiseli ezifileyo kunye nezinto zangaphandle. Rhoqo, abantu banokufumana ilifa lokusilela kwezinye iiprotein ezincedisayo. Aba bantu bathambekele kusulelo oluthile okanye ukuphazamiseka komzimba.

Zilithoba iiprotheyini zokuncedisa. Babhalwe i-C1 nge-C9. Eli nqaku lichaza uvavanyo olulinganisa imisebenzi iyonke yokuxhasa.

Isampulu yegazi iyafuneka. Oku kuhlala kuthathwa ngemithambo. Inkqubo ibizwa ngokuba yi-venipuncture.

Akukho lungiselelo lukhethekileyo.

Xa kufakwa inaliti ukutsala igazi, abanye abantu beva iintlungu kancinci. Abanye banokuziva ngathi babethwa okanye bahlatywe. Emva koko, kunokubakho ukuthotywa okuthile.

Umsebenzi opheleleyo wokuncedisa (CH50, CH100) ujonga imisebenzi iyonke yenkqubo yokuncedisa. Kwiimeko ezininzi, ezinye iimvavanyo ezichazwe ngakumbi kwisifo esikrokrelwayo zenziwa kuqala. I-C3 kunye ne-C4 zizinto zokuncedisa ezilinganiswe rhoqo.

Uvavanyo lokuncedisa lungasetyenziselwa ukubeka esweni abantu abanesifo sokuzimela. Kukwasetyenziselwa ukubona ukuba unyango lweemeko zabo luyasebenza na. Umzekelo, abantu abane-lupus erythematosus esebenzayo banokuba namanqanaba asezantsi kunalawo aqhelekileyo okuxhasa iiproteni ze-C3 kunye ne-C4.

Umsebenzi wokuncedisa uyahluka emzimbeni wonke. Umzekelo, kubantu abane-arthritis ye-rheumatoid, umsebenzi wokuncedisa egazini unokuba yinto eqhelekileyo okanye ephezulu kuneyona iqhelekileyo, kodwa isezantsi kakhulu kunesiqhelo kulwelo oluhlangeneyo.

Abantu abanosulelo lwegazi lwebhaktiriya kunye nokothuka bahlala bene-C3 ephantsi kakhulu kunye nezinto zento eyaziwa ngokuba yenye indlela. I-C3 ihlala iphantsi kwizifo zokungunda kunye nosulelo lwesinambuzane olufana nesifo seengcongconi.

Iziphumo eziqhelekileyo zolu vavanyo zezi:

• Inqanaba lokugcwalisa igazi lilonke: iiyunithi ezingama-41 ukuya kwezingama-90 zehemolytic
• Inqanaba leC1: 14.9 ukuya kwi-22.1 mg / dL
• Amanqanaba e-C3: 88 ukuya kwi-201 mg / dL
• Amanqanaba e-C4: 15 ukuya kwi-45 mg / dL

Qaphela: mg / dL = milligrams kwidesilitha nganye.

Qaphela: Uluhlu lwamaxabiso aqhelekileyo luyahluka kancinci phakathi kweelebhu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Imizekelo engentla ibonisa imilinganiselo eqhelekileyo yeziphumo zolu vavanyo. Ezinye iilabhoratri zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo.

Ukonyusa imisebenzi yokuxhasa kunokubonwa ku:

• Umhlaza
• Izifo ezithile
• Ukudumba okwenziwa sisilonda sikabhobhosi

Ukuncipha komsebenzi wokuncedisa kunokubonwa ku:

• Isibindi
• IGlomerulonephritis
• I-angioedema yelifa
• Hepatitis
• Ukhatywa kwezintso
• Lupus nephritis
• Ukungondleki
• Inkqubo ye lupus erythematosus
• Ukunqongophala kunqabile okuza kuzuzwa njengelifa

Iingozi ezinxulunyaniswa nokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

"Umncedisi we-cascade" luthotho lwempendulo ezenzeka egazini. I-Cascade isebenza ngokuhambelana neeproteni. Isiphumo yeyunithi yohlaselo eyenza imingxunya kwimbumba yebacteria, ibabulale.

Gcwalisa uvavanyo; Zalisa iiproteni

• Uvavanyo lwegazi

IChernecky CC, iBerger BJ. C. Kwi: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 266-432.

IiHolers VM. Gqibezela kunye nabamkeli bayo: ukuqonda okutsha kwizifo zabantu. U-Annu Rev Immunol. Ngo-2014; 3: 433-459. IINKCUKACHA: 24499275 www.ncbi.nlm.nih.gov/pubmed/24499275.

I-Merle NS, iBandla SE, iFremeaux-Bacchi V, iRoumenina LT. Inkqubo yokugcwalisa icandelo le-I-molecular of activation and regulation. I-Immunol yangaphambili. Ngo-2015; 6: 262. IINKCUKACHA: 26082779 www.ncbi.nlm.nih.gov/pubmed/26082779.

IMerle NS, uNowa R, iHalbwachs-Mecarelli L, iFremeaux-Bacchi V, iRoumenina LT. Inkqubo yokugcwalisa icandelo II: indima ekukhuseleni. I-Immunol yangaphambili. Ngo-2015; 6: 257. IINKCUKACHA: 26074922 www.ncbi.nlm.nih.gov/pubmed/26074922.

UMorgan BP, uHarris CL. Ukuzalisa, ekujolise kuko kunyango lwezifo ezitshisayo kunye nokwehla. Nat Rev iziyobisi Discov. 2015; 14 (2): 857-877. IINKCUKACHA: 26493766 www.ncbi.nlm.nih.gov/pubmed/26493766.