UAldesleukin

Umxholo

• Ngaphambi kokufumana i-aldesleukin,
• I-Aldesleukin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

Inaliti ye-Aldesleukin kufuneka inikwe esibhedlele okanye kwiziko lonyango phantsi kweliso likagqirha onamava ekunikeni amayeza e-chemotherapy kumhlaza.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi naphambi konyango lwakho ukuze abone ukuba kukhuselekile na kuwe ukufumana inaliti yealdesleukin kwaye ujonge impendulo yomzimba wakho kwisitofu sealdesleukin.

I-Aldesleukin inokubangela ukusabela okunamandla nokusongela ubomi okubizwa ngokuba yi-capillary leak syndrome (imeko ebangela ukuba umzimba ugcine ulwelo olugqithisileyo, uxinzelelo lwegazi olusezantsi, kunye namanqanaba asezantsi eproteni [albumin] egazini) anokubangela umonakalo Intliziyo, imiphunga, izintso, kunye namathumbu. I-capillary leak syndrome inokwenzeka kwangoko emva kokuba i-aldesleukin inikwe. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngokukhawuleza: ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi; ukutyeba kwakho; ukuqhawukelwa ngumphefumlo; isiqaqa; utywala okanye intloko; ukudideka; enegazi okanye emnyama, linda, ilindle elinamathelayo; iintlungu zesifuba; ukukhawuleza kwentliziyo okanye okungaqhelekanga.

I-Aldesleukin inokubangela ukwehla kwenani leeseli ezimhlophe egazini. Ukuhla kwenani leeseli ezimhlophe emzimbeni wakho kunokunyusa umngcipheko wokuba ube nosulelo olubi. Ukuba unazo naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: umkhuhlane, ukugodola, umqala obuhlungu, ukukhohlela, ukuchama rhoqo okanye ukuqaqanjelwa, okanye ezinye iimpawu zosulelo.

I-Aldesleukin inokuchaphazela inkqubo yeemvakalelo kwaye inokubangela isiqaqa. Ukuba unazo naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: ukulala kakhulu okanye ukudinwa.

I-Aldesleukin isetyenziselwa ukunyanga i-renal cell carcinoma (RCC, uhlobo lomhlaza oluqala kwizintso) oluye lwasasazeka kwamanye amalungu omzimba wakho. I-Aldesleukin ikwasetyenziselwa ukunyanga i-melanoma (uhlobo lomhlaza wolusu) ethe yasasazeka kwamanye amalungu omzimba wakho. I-Aldesleukin ikudidi lweziyobisi ezaziwa ngokuba zii cytokines. Yinguqulelo eyenziwe ngumntu yeprotein eyenzeka ngokwendalo evuselela umzimba ukuba uvelise ezinye iikhemikhali ezonyusa amandla omzimba okulwa nomhlaza.

I-Aldesleukin iza njengomgubo oxutywe nolwelo ukuze ifakwe ngaphakathi ngaphakathi (emthanjeni) ngaphezulu kwemizuzu eli-15 ngugqirha okanye ngumongikazi esibhedlele. Ihlala itofwe rhoqo emva kweeyure ezisi-8 iintsuku ezintlanu zilandelelana (iinaliti ezili-14 zizonke). Lo mjikelo unokuphindwa emva kweentsuku ezili-9. Ubude bonyango buxhomekeke kwindlela ophendula ngayo emzimbeni wakho kunyango.

Ugqirha wakho unokufuna ukulibaziseka okanye ayeke ngokusisigxina unyango lwakho ukuba uneziphumo ebezingalindelekanga ezithile. Uya kujonga ngononophelo ngexesha lonyango lwakho kunye ne-aldesleukin. Kubalulekile ukuba uxelele ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho kunye ne-aldesleukin.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana i-aldesleukin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-aldesleukin, nawaphi na amanye amayeza, okanye nasiphi na isithako sealdesleukin injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: ii-beta blocker ezinje nge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), kunye nepropranolol (Inderal); amayeza athile e-chemotherapy amayeza anje nge-asparaginase (Elspar), cisplatin (Platinol), dacarbazine (DTIC-dome), doxorubicin (Doxil), interferon-alfa (Pegasys, PEG-Intron), methotrexate (Rheumatrex, Trexall), kunye netamoxifen ( ); amayeza kuxinzelelo lwegazi; amayeza isicaphucaphu nokugabha; iziyobisi nezinye iintlungu; ukuthomalalisa, iipilisi zokulala, kunye noxinzelelo i-steroids ezinje nge-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (Medrol), kunye ne-prednisone (Deltasone); kunye ne-steroid cream, lotions, okanye mafutha anje ngehydrocortisone (Cortizone, Westcort). Xelela ugqirha wakho kunye nosokhemesti malunga nawo onke amayeza owathathayo ukuze bajonge ukuba ngaba nawaphi na amayeza akho anokuwonyusa umngcipheko wokuba uya kukhula ukonakala kwezintso okanye kwesibindi ngexesha lonyango lwakho kunye ne-aldesleukin.
• xelela ugqirha wakho ukuba ukhe waxhuzula, isisu (GI) ukopha kufuna unyango, okanye enye ingxaki ye-GI, intliziyo, inkqubo yeemvakalelo, okanye iingxaki zezintso emva kokuba ufumene i-aldesleukin okanye ukuba wakha watyalwa ilungu ilungu emzimbeni). Ugqirha wakho usenokungafuni ukuba ufumane i-aldesleukin.
• xelela ugqirha wakho ukuba ukhe waxhuzula, isifo sikaCrohn, iscleroderma (isifo esichaphazela izicwili ezixhasa ulusu kunye namalungu angaphakathi), isifo se-thyroid, isifo samathambo, isifo seswekile, i-myasthenia gravis (isifo esenza buthathaka izihlunu), okanye cholecystitis (ukudumba kwe-gall bladder okubangela iintlungu eziqatha).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa ufumana i-aldesleukin, tsalela ugqirha wakho. Akufanele uncancise umntwana ngelixa ufumana i-aldesleukin.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

I-Aldesleukin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• Ukuphelelwa ngumdla wokutya
• izilonda emlonyeni nasemqaleni
• ukudinwa
• ubuthathaka
• isiyezi
• imvakalelo ngokubanzi yokungaphili
• iintlungu okanye ububomvu kwindawo apho bekutofwe inaliti

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukuxhuzula
• iintlungu zesifuba
• ixhala kakhulu
• imincili engaqhelekanga okanye ukuphazamiseka
• uxinzelelo olutsha okanye olubi
• ukubona izinto okanye ukuva amazwi angekhoyo (hallucinating)
• utshintsho kumbono wakho okanye kwintetho
• ukulahleka koququzelelo
• ukunciphisa ukuqaphela
• ukugruzuka okanye ukopha okungaqhelekanga
• ukulala kakhulu okanye ukudinwa
• ubunzima bokuphefumla
• ukuvutha
• isisu esibuhlungu
• mthubi ulusu okanye amehlo
• ukuncipha kokuchama
• irhashalala
• urhwebo
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya

I-Aldesleukin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukuxhuzula
• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• ikhoma
• ukuncipha kokuchama
• ukudumba kobuso, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa okungaqhelekanga okanye ubuthathaka
• isisu esibuhlungu
• ukugabha okunegazi okanye okujongeka njengendawo yekofu
• igazi esitulweni
• izitulo ezimnyama kunye nokulinda

Ukuba une-x-reyi, xelela ugqirha ukuba ufumana unyango lwe-aldesleukin.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Iproleukin^®

• I-Interleukin-2