Inaliti yeFilgrastim

Umxholo

• Ngaphambi kokusebenzisa iimveliso zenaliti yefilgrastim,
• Iimveliso zenaliti yeFilgrastim inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

Inaliti yeFilgrastim, inaliti ye-filgrastim-aafi, inaliti ye-filgrastim-sndz, kunye nenaliti ye-tbo-filgrastim ngamayeza e-biologic (amayeza enziwe kwizinto eziphilayo). Inaliti ye-Biosimilar filgrastim-aafi, inaliti ye-filgrastim-sndz, kunye nenaliti ye-tbo-filgrastim ifana kakhulu nenaliti ye-filgrastim kwaye isebenza ngendlela efanayo ne-filgrastim injection emzimbeni. Ke ngoko, igama elithi iimveliso zeenaliti ze-filgrastim ziya kusetyenziswa ukumela la mayeza kule ngxoxo.

Iimveliso zenaliti yeFilgrastim (iGranix, iNeupogen, iNivestym, iZarxio) zisetyenziselwa ukunciphisa amathuba osulelo kubantu abangenawo umhlaza ongena-myeloid (umhlaza ongabandakanyi umongo wethambo) kwaye bafumana amayeza e-chemotherapy anokunciphisa inani le-neutrophils ( uhlobo lweseli yegazi olufunekayo ukulwa usulelo). Iimveliso zenaliti yeFilgrastim (Neupogen, Nivestym, Zarxio) zikwasetyenziselwa ukunceda ukwandisa inani leeseli ezimhlophe zegazi, kunye nokunciphisa ubude bexesha elinomkhuhlane kubantu abane-acute myeloid leukemia (AML; uhlobo lomhlaza weeseli ezimhlophe zegazi) abafumana unyango ngamayeza e-chemotherapy.Iimveliso zenaliti yeFilgrastim (Neupogen, Nivestym, Zarxio) ziyasetyenziswa nakubantu abafumana utyando lomongo wethambo, kubantu abane-neutropenia engapheliyo (imeko apho kukho inani eliphantsi le-neutrophils egazini), kunye nokulungiselela igazi I-leukapheresis (unyango apho iiseli ezithile zegazi zisuswe emzimbeni. Ifilgrastim ikudidi lwamayeza abizwa ngokuba zizinto ezikhuthaza ikoloni.Isebenza ngokunceda umzimba ukuba wenze ii-neutrophils ezingakumbi.

Iimveliso zenaliti yeFilgrastim iza njengesisombululo (ulwelo) kwiibhotile kunye neesirinji ezizalisiweyo zokutofa phantsi kolusu okanye emthanjeni. Ihlala inikwa kube kanye ngosuku, kodwa iimveliso zenaliti yefilgrastim (Neupogen, Nivestym, Zarxio) inokunikwa kabini ngemini xa isetyenziselwa ukunyanga i-neutropenia engapheliyo. Ubude bonyango lwakho buxhomekeke kwimeko onayo kunye nendlela ophendula ngayo emzimbeni wakho kunyango.

Ukuba usebenzisa iimveliso zenaliti ye-filgrastim ukunciphisa umngcipheko wosulelo, ukunciphisa ixesha elinomkhuhlane, okanye ukonyusa inani leeseli ezimhlophe ngexesha lokunyanga ngamayeza, uya kufumana idosi yakho yokuqala yeyeza ubuncinci iiyure ezingama-24 emva kokufumana idosi chemotherapy, kwaye uya kuqhubeka nokufumana amayeza yonke imihla ukuya kuthi ga kwiiveki ezi-2 okanye de ukubala kweseli yakho yegazi kubuyele esiqhelweni. Ukuba usebenzisa imveliso yenaliti ye-filgrastim ukunciphisa umngcipheko wosulelo ngexesha lokufakwa komongo wethambo, uyakufumana amayeza ubuncinci kwiiyure ezingama-24 emva kokuba ufumene ichemotherapy kwaye ubuncinci iiyure ezingama-24 emva kokufakwa komongo wethambo. Ukuba usebenzisa iimveliso zenaliti yefilgrastim ukulungiselela igazi lakho leukapheresis, uyakufumana idosi yakho yokuqala ubuncinci kwiintsuku ezi-4 ngaphambi kweleukapheresis yokuqala kwaye uya kuqhubeka nokufumana amayeza de kube leukapheresis yokugqibela. Ukuba usebenzisa iimveliso zenaliti ye-filgrastim ukunyanga i-neutropenia engapheliyo, kusenokufuneka usebenzise iyeza ixesha elide. Ukuba usebenzisa inaliti ye-filgrastim ngenxa yokuba uchanekile kwimilinganiselo eyingozi yemitha, ugqirha wakho uya kukujonga ngononophelo kwaye ubude bonyango lwakho buya kuxhomekeka ekubeni umzimba wakho uphendula njani kunyango. Sukuyeka ukusebenzisa iimveliso zenaliti ngaphandle kokuthetha nogqirha wakho.

Iimveliso zokuthambisa ngefilgrastiminjection ungazinikwa ngumongikazi okanye ngomnye umboneleli wezempilo, okanye unokuxelelwa ukuba utofe iyeza phantsi kolusu ekhaya. Ukuba wena okanye umnakekeli uya kutofa iimveliso zenaliti yefilgrastim ekhaya, umboneleli wokhathalelo lwempilo uya kukubonisa okanye umkhathalele ukuba ungalifaka njani iyeza. Qiniseka ukuba uyayiqonda le ndlela. Buza umboneleli wakho wezempilo ukuba unemibuzo. Sebenzisa iimveliso zenaliti yefilgrastim ngokuchanekileyo njengoko kuyalelwe. Sukuyisebenzisa ngaphezulu okanye ngaphantsi okanye uyisebenzise rhoqo kunokuyalelwa ngugqirha.

Sukushukumisa iingqayi okanye iisirinji ezinesisombululo se-filgrastim. Ngalo lonke ixesha jonga iimveliso zenaliti yefilgrastim ngaphambi kokufaka inaliti. Sukuwusebenzisa ukuba umhla wokuphelelwa uphelile, okanye ukuba isisombululo se-filgrastim sinamasuntswana okanye sijongeka sinogwebu, sinamafu, okanye sibala ibala.

Sebenzisa isirinji nganye okanye igutyana kube kanye. Nokuba kusekho isisombululo esishiyiweyo kwisirinji okanye igutyana, ungasisebenzisi kwakhona. Lahla iinaliti, iisirinji kunye neebhotile kwisitya esinganyangekiyo. Thetha nogqirha wakho okanye usokhemesti malunga nokusilahla isikhongozeli esinganyangekiyo.

Ugqirha wakho unokukuqala kwidosi esezantsi yeemveliso zefilastastim ngenaliti kwaye ngokuthe ngcembe wandise idosi yakho. Ugqirha wakho unokunciphisa idosi yakho, kuxhomekeke kwindlela umzimba wakho osabela ngayo kunyango.

Ukuba usebenzisa iimveliso zenaliti ye-filgrastim ukunyanga i-neutropenia engapheliyo, kuya kufuneka uyazi ukuba eli yeza liza kuyilawula imeko yakho kodwa aliyi kuyinyanga. Qhubeka nokusebenzisa iimveliso zenaliti yefilgrastim nokuba uziva uphilile. Sukuyeka ukusebenzisa iimveliso zenaliti ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Iimveliso zenaliti yeFilgrastim ngamanye amaxesha zisetyenziselwa ukunyanga iintlobo ezithile zesifo se-myelodysplastic (iqela leemeko apho umongo wethambo uvelisa iiseli zegazi ezingafakwanga kakuhle kwaye zingavelisi iiseli zegazi ezifanelekileyo) kunye ne-aplastic anemia (imeko apho umongo wethambo ayenzi iiseli zegazi ezaneleyo). Iimveliso zenaliti yeFilgrastim ngamanye amaxesha zisetyenziselwa ukunciphisa amathuba osulelo kubantu abanentsholongwane kaGawulayo (i-HIV) okanye abantu abathatha amayeza athile anciphisa inani le-neutrophils. Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa iimveliso zenaliti yefilgrastim,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-filgrastim, i-pegfilgrastim (i-Neulasta), nawaphi na amanye amayeza okanye naziphi na izithako ezikwi-filgrastim injection products. Xelela ugqirha wakho ukuba wena okanye umntu oza kufaka inaliti ye-filgrastim (Neupogen, Zarxio) ayidibani ne-latex.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba uphathwa ngonyango lwe-radiation kwaye ukuba unayo okanye wakha wanayo i-myeloid leukemia (isifo esihamba kancinci kancinci apho iiseli ezimhlophe zegazi zenziwa kumongo wethambo), okanye i-myelodysplasia (iingxaki zeseli zomongo wethambo) ezinokukhula zibe ngumhlaza wegazi).
• xelela ugqirha wakho ukuba unesifo se-sickle cell (isifo segazi esinokubangela iingxaki ezibuhlungu, inani eliphantsi leeseli ezibomvu zegazi, usulelo kunye nomonakalo kwizitho zangaphakathi). Ukuba unesifo se-sickle cell, unokuba nethuba lokufumana ingxaki ngexesha lonyango lwakho ngemveliso yenaliti yefilgrastim. Sela ulwelo oluninzi ngexesha lonyango lwakho ngemveliso yenaliti yefilgrastim kwaye ubize ugqirha ngoko nangoko ukuba unengxaki yeseli erhengqayo ngexesha lonyango lwakho.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa usebenzisa i-filgrastim inaliti iimveliso fowunela ugqirha wakho.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba usebenzisa iimveliso zenaliti yefilgrastim.
• Kuya kufuneka uyazi ukuba iimveliso zenaliti ye-filgrastim inciphisa umngcipheko wosulelo, kodwa ayikuthinteli lonke usulelo olunokuthi lukhule ngexesha okanye emva kwe-chemotherapy. Fowunela ugqirha wakho xa uvela iimpawu zosulelo ezifana nomkhuhlane; Ukugodola; irhashalala; umqala obuhkungu; urhudo; okanye ubomvu, ukudumba, okanye iintlungu ezijikeleze ukusika okanye ukuqaqamba.
• ukuba ufumana isisombululo se-filgrastim kulusu lwakho, hlamba loo ndawo ngesepha namanzi. Ukuba isisombululo se-filgrastim singena kwiliso lakho, gungxula iliso lakho kakuhle ngamanzi.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uza kutofa inaliti ye-filgrastim ekhaya, thetha nogqirha wakho malunga nento ekufuneka uyenzile ukuba uyalibala ukujova iyeza kwishedyuli.

Iimveliso zenaliti yeFilgrastim inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ububomvu, ukudumba, ukugruzuka, ukurhawuzelela okanye iqhuma kwindawo apho lalifakwe khona iyeza
• ithambo, ukudibana, umqolo, ingalo, umlenze, umlomo, umqala, okanye iintlungu
• intloko ebuhlungu
• irhashalala
• ukuqhina
• urhudo
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• ubunzima bokulala okanye ukulala
• ukuncipha kwengqondo yokuthinta
• ukulahleka kweenwele
• impumlo
• ukudinwa, ukungabikho kwamandla
• ndiziva ndingaphilanga
• isiyezi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• iintlungu kwinxalenye ephezulu yasekhohlo yesisu okanye kwincam yegxalaba lasekhohlo
• umkhuhlane, umphefumlo omfutshane, ingxaki yokuphefumla, ukuphefumla ngokukhawuleza
• ingxaki yokuphefumla, ukukhwehlela igazi
• umkhuhlane, iintlungu esiswini, umqolo obuhlungu, ukuziva ungaphilanga
• ukudumba kwendawo yesisu okanye okunye ukudumba, ukuncipha kokuchama, ukuphefumla okungxaki, isiyezi, ukudinwa
• irhashalala, urticaria, ukurhawuzelela, ukudumba kobuso, amehlo, okanye umlomo, ukuvutha, ukuphefumla kancinci
• ukopha okungaqhelekanga okanye ukugruzuka, ukumakishwa okumfusa ngaphantsi kolusu, ulusu olubomvu
• ukuncipha kokuchama, umchamo omnyama okanye onegazi, ukudumba kobuso okanye amaqatha
• Ukuchama kabuhlungu, ngokungxamisekileyo, okanye rhoqo

Abanye abantu abasebenzisa iimveliso zenaliti ye-filgrastim ukunyanga i-neutropenia engapheliyo i-leukemia (umhlaza oqala kumongo wethambo) okanye utshintsho kwiiseli zomongo wethambo ezibonisa ukuba i-leukemia inokukhula kwixesha elizayo. Abantu abane-neutropenia engapheliyo banokuhlakulela i-leukemia nangona bengasebenzisi i-filgrastim. Akukho lwazi lwaneleyo ukuxelela ukuba iimveliso zenaliti ye-filgrastim yonyusa amathuba okuba abantu abane-neutropenia engapheliyo baya kuba ne-leukemia. Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza.

Iimveliso zenaliti yeFilgrastim inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina iimveliso zenaliti yefriji kwifriji. Ukuba ngempazamo umise ifilgrastim (Neupogen, Nivestym, Zarxio), ungayivumela inyibilike kwifriji. Nangona kunjalo, ukuba ufriza isirinji efanayo okanye igutyana le-filgrastim okwesibini, kuya kufuneka uyilahle isirinji okanye igutyana. I-Filgrastim (Neupogen, Nivestym, Zarxio) inokugcinwa kubushushu begumbi ukuya kuthi ga kwiiyure ezingama-24 kodwa kufuneka igcinwe kude elangeni ngqo. I-Filgrastim (i-Granix) inokugcinwa kwisikhenkcezisi ukuya kuthi ga kwiiyure ezingama-24, okanye inokugcinwa kubushushu begumbi ukuya kwiintsuku ezintlanu kodwa kufuneka ikhuselwe ekukhanyeni.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwiimveliso zenaliti yefilgrastim.

Ngaphambi kokuba wenze isifundo sokucinga ngemathambo, xelela ugqirha wakho kunye negcisa lakho ukuba usebenzisa iimveliso zenaliti yefilgrastim. Iimveliso zenaliti yeFilgrastim inokuchaphazela iziphumo zolu hlobo lokufunda.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• IGranix^® (tbo-filgrastim)
• Neupogen^® (ifilimu)
• Nivestym^® (ifilgrastim-aafi)
• Zarxio^® (ifilgrastim-sndz)

• I-Granulocyte Colony-ekhuthazayo yeFactor
• G-CSF
• Ukuphindaphinda kweMethionyl yoLuntu G-CSF