Thalidomide

Umxholo

• Ngaphambi kokuba uthathe i-thalidomide,
• I-Thalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Umngcipheko weziphene ezinzima, ezisongela ubomi zokuzalwa ezibangelwa yi-thalidomide.

Kubo bonke abantu abathatha i-thalidomide:

I-Thalidomide akufuneki ithathwe ngabafazi abakhulelweyo okanye abanokukhulelwa ngelixa besebenzisa la mayeza. Nokuba ithamo elinye le-thalidomide elithathiweyo ngexesha lokukhulelwa linokubangela iziphene zokuzalwa ezinzima (iingxaki zomzimba ezikhoyo kusana xa luzalwa) okanye ukusweleka kosana olungekazalwa. Inkqubo ebizwa ngokuba yiThalidomide REMS^® (eyayisaziwa njengeNkqubo yeMfundo yeThalidomide kunye noKhuseleko oluMiselweyo [S.T.E.P.S.^®]) yamkelwe yi-Food and Drug Administration (i-FDA) ukuqinisekisa ukuba abasetyhini abakhulelweyo abayithathi i-thalidomide kwaye abasetyhini abakhulelwa ngelixa bethatha i-thalidomide. Bonke abantu abanikwe i-thalidomide, kubandakanya amadoda nabafazi abangakwaziyo ukukhulelwa, kufuneka babhaliswe kwi-Thalidomide REMS^®, Unayo i-thalidomide prescription evela kugqirha obhaliswe kwi-Thalidomide REMS^®, kwaye ugcwaliselwe amayeza kwikhemesti ebhaliswe kwi-Thalidomide REMS^® ukuze ufumane la mayeza.

Uya kudinga ukubona ugqirha wakho inyanga nenyanga ngexesha lonyango lwakho ukuze uthethe ngemeko yakho kunye naziphi na iziphumo ebezingalindelekanga onokuthi ube nazo. Kutyelelo ngalunye, ugqirha wakho unokukunika amayeza anikezela ngeentsuku ezingama-28 zamayeza ngaphandle kokuzalisa kwakhona. Kufuneka ube nalo eli gqirha lizaliswe zingekapheli iintsuku ezisi-7.

Musa ukunikela ngegazi ngelixa uthatha i-thalidomide kunye neeveki ezi-4 emva konyango lwakho.

Musa ukwabelana nge-thalidomide kunye nabani na ongomnye, nokuba ngubani onokuba neempawu ezifanayo nezakho.

Abafazi bathatha i-thalidomide:

Ukuba unokukhulelwa, kuya kufuneka uhlangabezane neemfuno ezithile ngexesha lonyango lwakho kunye ne-thalidomide. Kuya kufuneka uhlangabeze ezi mfuno nokuba unembali yokungakwazi ukukhulelwa. Unokuxolelwa ekuhlangabezeni ezi mfuno kuphela ukuba awuyanga exesheni (unethuba) leenyanga ezingama-24 zilandelelana, okanye uye wanesibeleko (utyando lokususa isibeleko sakho).

Kuya kufuneka usebenzise iindlela ezimbini ezamkelekileyo zolawulo lokuzalwa iiveki ezi-4 ngaphambi kokuba uqale ukuthatha i-thalidomide, ngexesha lonyango lwakho, kunye neeveki ezi-4 emva konyango lwakho. Ugqirha wakho uya kukuxelela ukuba zeziphi iindlela zolawulo lokuzalwa ezamkelekileyo. Kuya kufuneka usebenzise ezi ndlela zimbini zokulawula ukuzalwa maxa onke ngaphandle kokuba unokuqinisekisa ukuba awuyi kuba nakunxibelelana ngokwesondo nendoda kangangeeveki ezi-4 ngaphambi konyango lwakho, ngexesha lonyango lwakho, kunye nakwiiveki ezi-4 emva konyango lwakho.

Amanye amayeza anokubangela ukuba izinto zokucwangcisa zehomoni zingasebenzi kakuhle. Ukuba uceba ukusebenzisa izinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, izixhobo zokufaka, iinaliti, amakhonkco, okanye izixhobo zangaphakathi) ngexesha lonyango lwakho nge-thalidomide, xelela ugqirha wakho ngawo onke amayeza, iivithamini, kunye nezongezo zamayeza owathathayo okanye oceba ukuzithatha. . Qiniseka ukukhankanya: griseofulvin (Grifulvin); amayeza athile okunyanga intsholongwane kaGawulayo (HIV) kubandakanya amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), ritonavir (Norviririr) , eKaletra), saquinavir (Invirase), kunye netipranavir (Aptivus); amayeza athile okubanjwa kubandakanya i-carbamazepine (Carbatrol, Equetro, Tegretol) kunye ne-phenytoin (Dilantin, Phenytek); imodafinil (Provigil); penicillin; irifampin (Rimactane, Rifadin); irifabutin (Mycobutin); kunye neSt. Uninzi lwamanye amayeza anokuphazamisa isenzo sezinto zokucwangcisa zehomoni, ke qiniseka ukuba uxelele ugqirha wakho onke amayeza owathathayo okanye ocwangcisayo ukuwathatha, nkqu nalawo angaveli kolu luhlu.

Kuya kufuneka ube uneemvavanyo ezimbini ezimbi zokukhulelwa ngaphambi kokuba uqale ukuthatha i-thalidomide. Kuya kufuneka ukuba uvavanywe ukukhulelwa elebhu ngamaxesha athile ngexesha lonyango lwakho. Ugqirha wakho uya kukuxelela ukuba nini kwaye phi.

Yeka ukuthatha i-thalidomide kwaye ubize ugqirha wakho ngoko nangoko ukuba ucinga ukuba ukhulelwe, unethuba lokufika emva kwexesha, elingaqhelekanga, okanye eliphosakeleyo lokuya exesheni, unalo naluphi na utshintsho ekwenziweni kwakho kokuya exesheni, okanye ulala ngesondo ngaphandle kokusebenzisa iindlela ezimbini zolawulo lokuzalwa. Ngamanye amaxesha, ugqirha wakho unokuyalela ukuthintela inzala ngexesha likaxakeka ('kusasa emva kwepilisi') ukuthintela ukukhulelwa. Ukuba ukhulelwe ngexesha lonyango lwakho, ugqirha wakho uyacelwa ukuba abize i-FDA kunye nomenzi wayo. Ugqirha wakho uya kuqinisekisa ukuba uthetha nogqirha ogxile kwiingxaki ngexesha lokukhulelwa onokuthi akuncede wenze ukhetho olulungele wena nosana lwakho.

Kumadoda athatha i-thalidomide:

I-Thalidomide ikhona kwisidoda (ulwelo olunesidoda esikhutshwa kwilungu lobudoda ngexesha le-orgasm). Kuya kufuneka usebenzise i-latex okanye ikhondom eyenziweyo okanye uphephe ngokupheleleyo nakuphi na ukunxibelelana ngokwesondo nowasetyhini okhulelweyo okanye onokukhulelwa ngelixa uthatha eli yeza kunye neeveki ezi-4 emva konyango lwakho. Oku kuyadingeka nokuba unayo i-vasectomy (utyando ukunqanda isidoda ekuphumeni emzimbeni wakho kwaye sibangele ukukhulelwa). Xelela ugqirha wakho kwangoko ukuba uye walala ngesondo ngokungakhuselekanga nomntu wasetyhini onokukhulelwa okanye ukuba ucinga ngaso nasiphi na isizathu ukuba iqabane lakho likhulelwe.

Sukunikela ngamadlozi okanye isidoda ngelixa uthatha i-thalidomide kunye neeveki ezi-4 emva konyango lwakho.

Umngcipheko wamahlwili egazi:

Ukuba uthatha i-thalidomide ukunyanga i-myeloma emininzi (uhlobo lomhlaza womongo wethambo), kukho umngcipheko wokuba uya kuba negazi kwingalo, emilenzeni okanye emiphungeni. Lo mngcipheko mkhulu xa kusetyenziswa i-thalidomide kunye namanye amayeza e-chemotherapy afana ne-dexamethasone. Fowunela ugqirha ngokukhawuleza ukuba unazo naziphi na kwezi mpawu zilandelayo: iintlungu, ukuthamba, ubomvu, ukufudumala, okanye ukudumba kwiingalo okanye emilenzeni; ukuqhawukelwa ngumphefumlo; okanye iintlungu esifubeni. Ugqirha wakho unokukunika i-anticoagulant ('igazi elincinci') okanye i-aspirin ukunceda ukumisa amahlwili ekubumbeni ngexesha lonyango lwakho nge-thalidomide.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-thalidomide.

I-Thalidomide isetyenziswa kunye ne-dexamethasone ukunyanga i-myeloma eninzi kubantu abasandula kufunyaniswa ukuba banesi sifo. Ikwasetyenziswa yodwa okanye namanye amayeza ukunyanga nokukhusela iimpawu zesikhumba se-erythema nodosum leprosum (ENL; iziqendu zezilonda zolusu, umkhuhlane kunye nomonakalo wemithambo-luvo owenzeka kubantu abanesifo sikaHansen [iqhenqa]. I-Thalidomide ikudidi lwamayeza abizwa ngokuba ziiarhente ze-immunomodulatory agents. Iphatha i-myeloma emininzi ngokuqinisa amajoni omzimba ukulwa neeseli zomhlaza. Iphatha i-ENL ngokuthintela isenzo sezinto ezithile zendalo ezibangela ukudumba.

I-Thalidomide iza njengecapsule ukuyithatha ngomlomo. I-Thalidomide ihlala ithathwa ngamanzi kanye ngemini ngexesha lokulala kwaye ubuncinci iyure emva kwesidlo sangokuhlwa. Ukuba uthatha i-thalidomide ukunyanga i-ENL, ugqirha wakho unokukuxelela ukuba uyithathe ngaphezu kwesinye ngosuku, ubuncinci iyure emva kokutya. Thatha i-thalidomide ngexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-thalidomide ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gcina iifomsile ekupakisheni kwazo de ube ukulungele ukuzithatha. Musa ukuvula iifomsile okanye uziphathe ngaphezulu kwemfuneko. Ukuba ulusu lwakho ludibana neephilisi okanye i-powder ezaphukileyo, hlamba indawo esecaleni ngesepha namanzi.

Ubude bonyango lwakho buxhomekeke kwindlela iimpawu zakho eziphendula ngayo kwi-thalidomide kunye nokuba iimpawu zakho ziyabuya na xa uyeka ukuthatha amayeza. Ugqirha wakho unokufuna ukuphazamisa unyango lwakho okanye ukunciphisa idosi yakho ukuba uneziphumo ebezingalindelekanga ezithile. Sukuyeka ukuthatha i-thalidomide ngaphandle kokuthetha nogqirha wakho. Xa unyango lwakho lugqityiwe ugqirha wakho uya kunciphisa idosi yakho ngokuthe ngcembe.

I-Thalidomide ngamanye amaxesha isetyenziselwa ukunyanga iimeko ezithile zolusu kubandakanya ukudumba kunye nokucaphuka. Isetyenziselwa ukunyanga iingxaki ezithile zentsholongwane yomntu (i-HIV) efana ne-aphthous stomatitis (imeko apho izilonda zenzeka khona emlonyeni), isifo sorhudo esihambelana ne-HIV, isifo sokudumba esihambelana ne-HIV, usulelo oluthile, kunye ne-Kaposi's sarcoma (uhlobo womhlaza wolusu). I-Thalidomide ikwasetyenziselwa ukunyanga ezinye iintlobo zomhlaza kunye namathumba, ukwehla kakhulu kwesisindo kwizigulana ezinamajoni omzimba abuthathaka, isifo esinganyangekiyo xa kuthelekiswa nezifo ezibanjwayo (ingxaki enokuthi yenzeke emva kokufakelwa komongo wethambo apho izinto ezisandula ukufakelwa zihlasela umamkeli wofakelo Umzimba), kunye nesifo sikaCrohn (imeko apho umzimba uhlasela khona umgca wokugaya, obangela iintlungu, urhudo, ukunciphisa umzimba kunye nomkhuhlane). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

La mayeza ngamanye amaxesha amiselweyo kwezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-thalidomide,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-thalidomide okanye nawaphi na amanye amayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: ii-barbiturates ezinje nge-pentobarbital (Nembutal), phenobarbital, kunye ne-secobarbital (Seconal); chlorpromazine; i-didanosine (Videx); amayeza oxinzelelo, ukugula ngengqondo, okanye ukuxhuzula; amayeza athile e-chemotherapy kumhlaza njenge-cisplatin (Platinol), paclitaxel (Abraxane, Taxol), kunye ne-vincristine; reserpine (Serpalan); ukuthomalalisa; iipilisi zokulala; kunye noxinzelelo. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unayo okanye wakha wanayo intsholongwane ye-immunodeficiency virus (HIV), ufumene i-immunodeficiency syndrome (i-AIDS), inqanaba eliphantsi leeseli ezimhlophe zegazi egazini lakho, okanye ukuxhuzula.
• xelela ugqirha wakho ukuba uncelisa.
• Kuya kufuneka uyazi ukuba i-thalidomide inokukwenza wozele. Sukuqhuba imoto, sebenzisa oomatshini, okanye wenze eminye imisebenzi efuna ukuba uqaphele ngokupheleleyo de ube uyazi ukuba lonyango lukuchaphazela njani.
• buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kweziselo ezinxilisayo ngelixa uthatha i-thalidomide. Utywala bunokwenza iziphumo ebezingalindelekanga ukuba zibi ngakumbi.
• Kuya kufuneka uyazi ukuba i-thalidomide inokubangela ukuba ube nesiyezi, ukuba nentloko elula, kunye nokuphelelwa ngamandla xa usukuma ngokukhawuleza kwindawo olele kuyo. Ukunceda ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume.
• Kuya kufuneka uyazi ukuba i-thalidomide ikhona egazini lakho nakwiincindi zomzimba. Nabani na onokudibana nala manzi kufuneka anxibe iigloves okanye ahlambe nayiphi na indawo ebonakalayo yesikhumba ngesepha namanzi.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 kude kube yidosi elandelayo ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Thalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukozela
• ukudideka
• ixhala
• ukudakumba okanye utshintsho kwiimvakalelo
• ubunzima bokulala okanye ukulala
• ithambo, umsipha, ukudibana, okanye iintlungu zomqolo
• ubuthathaka
• intloko ebuhlungu
• ukutshintsha ukutya
• utshintsho lobunzima
• isicaphucaphu
• ukuqhina
• umlomo owomileyo
• isikhumba esomileyo
• ulusu oluthuthu
• ukushukuma okungalawulekiyo kwilungu lomzimba
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokufezekisa okanye ukugcina ulwakhiwo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• ukurhawuzelela
• urhwebo
• ukudumba nokuxobuka kolusu
• ukudumba kobuso, umqala, ulwimi, imilebe, okanye amehlo
• ukudinwa
• ubunzima bokuginya okanye ukuphefumla
• umkhuhlane, umqala obuhlungu, Ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo
• ukubetha kwentliziyo kancinci okanye okukhawulezayo
• ukuxhuzula

I-Thalidomide inokubangela ukonakala kwemithambo-luvo okunokuba nzima kwaye kusisigxina. Lo monakalo unokubakho nangaliphi na ixesha ngexesha okanye emva konyango lwakho. Ugqirha wakho uya kukuvavanya rhoqo ukuze abone ukuba i-thalidomide iyichaphazele njani inkqubo yakho yeemvakalelo. Ukuba unazo naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-thalidomide kwaye ubize ugqirha ngoko nangoko: ukuba ndindisholo, ukurhawuzelela, iintlungu, okanye ukutshisa ezandleni nasezinyaweni.

I-Thalidomide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-thalidomide.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Thalomid^®