Ngaba iipilisi zokutya zeAlli (Orlistat) ziyasebenza? Uphengululo olusekwe kubungqina

Umxholo

• Yintoni iAlli (Orlistat)?
• Usebenza njani uAli?
• UAlli unokukunceda ukuba ulahlekelwe sisixa esincinci sobunzima
• Izifundo ezingakumbi
• Ngaba iipilisi zokutya zeAlli zinazo naziphi na ezinye izibonelelo zempilo?
• Iziphumo ebezingalindelekanga, idosi kunye nendlela yokuSebenzisa
• Ngaba kufuneka uzame uAlli?

Ukunciphisa umzimba kunokuba nzima kakhulu.

Olunye uphononongo lubonisa ukuba i-85% yabantu iyasilela ukusebenzisa iindlela eziqhelekileyo zokunciphisa umzimba (1).

Oku kubangela ukuba abantu abaninzi bafune ezinye iindlela, ezinje ngeepilisi zokutya, zoncedo.

I-Alli yenye yeepilisi zokutya, kodwa sisiyobisi esenza amayeza endaweni yesongezelelo esisekwe kwizityalo.

Eli chiza linciphisa inani lokutya okunamafutha kwimizimba yethu, ethi inciphise ukutya ikhalori kwaye ikhokelele ekunciphiseni umzimba.

Olu luphononongo oluneenkcukacha lweepilisi zokutya zeAlli: ziyintoni, zisebenza njani, nokuba zikulungele na.

Yintoni iAlli (Orlistat)?

I-Alli yinguqulelo engaphaya kwekhawuntarethi yamachiza okuphulukana nobunzima ekuthiwa yi-orlistat.

Inguqulelo yonyango kuphela ibizwa ngokuba yiXenical, equlathe idosi ephezulu. Iipilisi zokutya ze-Alli ziqukethe i-60 mg ye-orlistat, ngelixa iipilisi ze-Xenical zine-120 mg.

Eli yeza lavunywa okokuqala yi-FDA ngo-1999. Ihlala imiselwe ulawulo lwexesha elide lokutyeba, kunye nokutya okunamafutha asezantsi, ukutya okunomda wekhalori.

I-Alli yinguqulelo engaphezulu kwe-counter ye-orlistat, ichiza lamayeza elisetyenziselwa ukulawula ukutyeba kakhulu. Ikwafumaneka ngugqirha njengoXenical.

Usebenza njani uAli?

U-Alli usebenza ngokuthintela umzimba ekufunxeni amanqatha okutya.

Ngokukodwa, ibhloka i-enzyme emathunjini ebizwa ngokuba lipase.

I-Lipase ibalulekile ekwetyisweni kwamafutha esiwatyayo. Kuyanceda ukwahlula amanqatha kwii-acid zamahala ezinokuthathwa ngumzimba.

Ngaphandle kwale enzyme, amanqatha okutya ayadlula ekucoleni emva koko agxothwe emzimbeni.

Njenge-lipase-inhibitor, u-Alli ubonakalisile ukunciphisa ukufunxwa kwamanqatha okutya malunga ne-30% ().

Kuba amanqatha okutya aphezulu kwiikhalori, oku kukhokelela kwiikhalori ezimbalwa ezenziwa ngumzimba, ezinokukhokelela ekulahlekeni kobunzima.

U-Alli uphazamisa ukwetyiswa kwamafutha okutya kunye neebhloko malunga neepesenti ezingama-30 zamafutha ekuthatheni. Oku kukhokelela kunciphiso ngokubanzi lwekhalori.

UAlli unokukunceda ukuba ulahlekelwe sisixa esincinci sobunzima

Izifundo ezininzi zabantu ezininzi zenziwe kwi-orlistat, indawo esebenzayo kwiipilisi zokutya zeAlli.

Okona kwaziwa kakhulu luphononongo lweSweden XENDOS, olubandakanya abantu abangama-3,305 abatyebe kakhulu kwaye bahlala iminyaka emi-4 (3).

Kwakukho amaqela amabini kolu phando. Omnye uthathe i-120 mg ye-orlistat, kathathu yonke imihla, ngelixa elinye iqela lithatha indawo ye-placebo.

Bonke abathathi-nxaxheba bayalelwa ukuba batye ii-calories ezimbalwa ezingama-800 ngosuku, kunye nokunciphisa amanqatha okutya kwi-30% yeekhalori. Baye bakhuthazwa ukuba bathathe uhambo mihla le.

Le grafu ibonisa utshintsho kubunzima kula maqela mabini ngaphezulu kweminyaka emi-4 (3):

Ngexesha lonyaka wokuqala, i-avareji yokwehla kwesisindo kwiqela elanyangwa i-orlistat yayingama-23.3 eekhilogram (10.6 kg), ngelixa iqela le-placebo laphulukana ne-13.6 yeekhilogram kuphela.

Njengoko kubonisiwe kwigrafu, kwabakho kwakhona ubunzima bokufumana ubunzima kuwo omabini la maqela ngaphezulu kweminyaka emi-3 eseleyo. Izigulana ezanyangwa i-Orlistat zaye zaphela zalahleka i-12.8 yeekhilogram (5.8 kg), xa kuthelekiswa ne-6.6 yeekhilogram (3.0 kg) kwabo bafumana indawo ye-placebo.

Ngokwolu phononongo, i-orlistat edityaniswe nokutya kunye nokuzilolonga inokwenza ukuba ulahlekelwe phantse kabini ubunzima besidlo kunye nokuzilolonga kuphela.

Izifundo ezingakumbi

Ngokophononongo lophononongo, i-avareji yenyanga ye-12 yokulahleka kwesisindo kubantu abadala abathatha i-orlistat imalunga ne-7.5 lbs (3.4 kg) enkulu kune-placebo ().

Oku kufikelela kwi-3.1% yobunzima bokuqala, obungachukumisi ngokukodwa. Kukwabonakala ngathi ubunzima buye babuya kancinci emva konyaka wokuqala kunyango.

Into enomdla kukuba, olunye uphononongo lubonise ukuba ukutya okune-carb ephantsi engenazidakamizwa kwakusebenza ngokufanelekileyo njenge-orlistat kunye nokutya okunamafutha asezantsi kudityanisiwe ().

I-Alli / i-orlistat sisiyobisi esisebenzayo sokulwa nokutyeba kakhulu, kunye nokwehla kwesisindo esiphakathi kwiinyanga ezili-12 siyi-3.4 kg (7.5 lbs) enkulu kune-placebo.

Ngaba iipilisi zokutya zeAlli zinazo naziphi na ezinye izibonelelo zempilo?

U-Alli unxibelelene nezinye izibonelelo zezempilo, mhlawumbi ngenxa yokuncipha kobunzima.

• Uhlobo oluncitshisiweyo lomngcipheko weswekile: Kwisifundo se-XENDOS, ukusetyenziswa kweminyaka emi-4 ye-orlistat kunciphise umngcipheko wokukhula kohlobo lwe-2 yeswekile ngo-37% (3).
• Ukunciphisa uxinzelelo lwegazi: Izifundo zibonisa ukuba i-Alli inokukhokelela ekunciphiseni uxinzelelo lwegazi (,).
• Ukuncitshiswa okupheleleyo- kunye ne-LDL-cholesterol: Izifundo zibonisa ukuba uAlli unokuchaphazela ngokuqinisekileyo amanqanaba e-cholesterol (,).

Ukusetyenziswa ixesha elide kuka-Alli kunokunciphisa umngcipheko wohlobo lweswekile 2 kunye nokunceda ukukhusela kwisifo sentliziyo.

Iziphumo ebezingalindelekanga, idosi kunye nendlela yokuSebenzisa

Iipilisi zokutya zeAlli zineziphumo ebezingalindelekanga ezibhalwe kakuhle nekufanele ukuba uziqaphele ().

Njengokuba bebhloka ukufunxwa kwamanqatha, ubukho bamanqatha angacetywanga emathunjini kunokubangela iimpawu zokugaya ukutya, ezinje ngeentlungu zesisu, urhudo kunye nokuthamba.

Abanye abantu banamava okungalawuleki kwendle kunye nokuzikhulula, izitulo ezinamafutha.

Ukuqhubeka nokusetyenziswa kweAlli kunokuphazamisa ukufunxeka kwezakha mzimba njengamavithamini A, D, E kunye noK.

Ngesi sizathu, ukuthatha i-multivitamin kunye nonyango kuyacetyiswa.

U-Alli unokuphazamisa ukufunxwa kwamanye amayeza, kwaye iimeko ezimbalwa ukusilela kwesibindi kunye netyhefu yezintso zixeliwe.

Abantu abathatha amayeza okanye abanayo nayiphi na imeko yonyango kufuneka babonane nogqirha ngaphambi kokuba bathathe iipilisi zokutya zeAlli.

Ngokusekwe kwidatha yexesha elide elinganiselweyo, uninzi lwezikhokelo zeklinikhi ziphakamisa ukuba i-Alli ayisetyenziswanga ngokuqhubekayo ngaphezulu kweenyanga ezingama-24.

Idosi efanelekileyo esetyenziswe kwizifundo yi-120 mg, kathathu ngemini.

Iipilisi zokutya iAlli zineziphumo ebezingalindelekanga ezininzi. Zingabangela iingxaki zokugaya ukutya kunye nokusilela kwezondlo, kwaye zinokuphazamisa amanye amayeza. Elona dosi lifundwe kakuhle yi-120 mg, kathathu ngemini.

Ngaba kufuneka uzame uAlli?

Iipilisi zokutya iAlli ziphakathi kwezinto ezimbalwa kakhulu ezinciphisa ukuncipha ezisebenza ngenqanaba elithile. Nangona kunjalo, iziphumo azithandeki njengoko uninzi lwabantu lunokuthanda.

Okona kungcono, unokulahla ubunzima obuninzi, kodwa kuphela xa zidityanisiwe ngokunciphisa umzimba ukutya kunye nokuzilolonga.

Ukongeza, iziphumo eziluncedo ekulahlekeni kwesisindo kufuneka zilinganiswe ngokuchasene neziphumo ezibi zokugaya ukutya kunye nokusilela okunokubakho kwezondlo.

Ungayichazanga eyakho, kufuneka kwakhona ukuba utye ikhalori-ethintelweyo, ukutya okunamafutha asezantsi, okungonwabisiyo kubantu abaninzi.

Ukuba ufuna ngokwenene ukunciphisa umzimba kwaye yigcine, emva koko ukutya iiprotheyini ezininzi kunye neecarbs ezimbalwa yeyona ndlela isebenzayo kwaye izinzile.