Yintoni iB-Cell Lymphoma?
Umxholo
- Ziziphi ii-subtypes ze-B-cell lymphoma?
- Ukuqokelela
- Ziintoni iimpawu?
- Inyangwa njani?
- Imitha
- Unyango ngamayeza
- Unyango lomzimba
- Ukufakelwa kweseli
- Ngaba zikhona iingxaki?
- Kunjani ukuchacha?
- Imbonakalo
Ushwankathelo
I-Lymphoma luhlobo lomhlaza oqala kwii-lymphocyte. IiLymphocyte ziiseli kumajoni omzimba. IHodgkin's kunye ne-non-Hodgkin's lymphoma zezona ntlobo zimbini ziphambili zelymphoma.
I-T-cell lymphoma kunye ne-B-cell lymphoma ziindidi ezimbini ze-non-Hodgkin's lymphoma. Kukho uhlobo olunqabileyo olubizwa ngokuba yi-NK-cell lymphoma.
Phakathi kwabantu abane-non-Hodgkin lymphoma, malunga neepesenti ezingama-85 bane-B-cell lymphoma.
Unyango lwe-B-cell lymphomas isekwe kwi-subtype ethile kunye nenqanaba lesifo.
Ziziphi ii-subtypes ze-B-cell lymphoma?
Zininzi iindidi ze-B-cell lymphoma, zombini ukukhula kancinci (ngokungakhathali) kunye nokukhula ngokukhawuleza (okukhohlakeleyo), kubandakanya:
| B-iseli engaphantsi | Iimpawu |
| Ukusasaza i-B-cell lymphoma enkulu (i-DLBCL) | Olu lolona hlobo luqhelekileyo lwe-non-Hodgkin's lymphoma. Ngumhlaza onochuku kodwa onokunyangeka onokuthi ubandakanye ii-lymph node kunye namanye amalungu. |
| I-lymphoma yesigxina | Olu luhlobo lwesibini oluqhelekileyo kwi-non-Hodgkin's lymphoma. Iyakhula kancinci kwaye ihlala iqala kwii-lymph node. |
| Iselfowuni isymphoma | Ngokubanzi kubandakanya ii-lymph node, umongo wethambo, udakada, kunye nenkqubo yesisu. |
| I-lymphocytic leukemia engapheliyo (i-CLL) / i-lymphocytic lymphoma (SLL) | Olu hlobo alunambitheki kwaye luchaphazela igazi kunye nomongo wethambo (i-CLL), okanye ii-lymph node kunye ne-spleen (SLL). |
| Inkqubo yokuqala ye-nervous lymphoma | Olu hlobo luhlala luqala kwingqondo okanye kwintambo yomqolo. Inxulunyaniswa neengxaki zokuzikhusela komzimba ezibangelwa nguGawulayo okanye amayeza okuchasa okusetyenziswa kulandela ukufakelwa komzimba. |
| Umda wobubanzi be-Splenic B-cell lymphoma | Olu luhlobo olukhula kancinci oluqala kwipeni kunye nomongo wethambo. |
| Indawo engaphandle komda we-B-cell lymphoma ye-MALT | Olu hlobo luhlala lubandakanya isisu. Inokuthi yenzeke kwimiphunga, ulusu, idlala lengqula, intlala yamathe, okanye iliso. |
| Indawo ye-Nodal esecaleni kwe-B-cell lymphoma | Olu luhlobo olunqabileyo, olukhula kancinci olufumaneka ikakhulu kwii-lymph node. |
| IBurkitt lymphoma | Olu luhlobo olukhula ngokukhawuleza oluqheleke kakhulu ebantwaneni. |
| Umhlaza wegazi leukemia | Olu luhlobo olukhula kancinci oluchaphazela udakada, ii-lymph node, kunye negazi. |
| I-Lymphoplasmacytic lymphoma (iWaldenstrom macroglobulinemia) | Le yinto enqabileyo, ekhula kancinci kwi-lymphoma yomongo wethambo, udakada, kunye ne-lymph node. |
| I-primary effusion lymphoma | Olu luhlobo olunqabileyo, olunolunya oluhlala lukhona kubantu abanamajoni omzimba abuthathaka. |
Ukuqokelela
Umhlaza ubekwa kwinqanaba ngokokude kunwenwe njani kwindawo yokuqala. I-non-Hodgkin's lymphoma ihlelwe ukusuka kwi-1 kuye kwi-4, kunye ne-4 yeyona ihamba phambili.
Ziintoni iimpawu?
Iimpawu ziyahluka ngohlobo lwe-B-cell lymphoma kunye nendlela eqhubele phambili ngayo. Ezi zezinye zeempawu eziphambili:
- i-lymph nodes ezidumbileyo entanyeni yakho, emakhwapheni, okanye kwi-groin
- iintlungu esiswini okanye ukudumba
- iintlungu zesifuba
- ukukhohlela
- ubunzima bokuphefumla
- umkhuhlane kunye nokubila ebusuku
- ukuhla ukusinda
- ukudinwa
Inyangwa njani?
Iindidi ezithile ze-lymphoma ezi-asymptomatic kunye ne-indolent azidingi nyango. Ugqirha usenokuncomela into eyaziwa ngokuba “kukulinda ulindile.” Oko kuthetha ukuba uya kulandelelana qho kwiinyanga ezimbalwa ukuqinisekisa ukuba umhlaza awuhambeli phambili. Ngamanye amaxesha, oku kuya kuqhubeka iminyaka.
Unyango lungaqala xa kuvela iimpawu okanye ukuba kukho iimpawu zokuqhubela phambili kwesifo. I-B-cell lymphoma ihlala ibandakanya indibaniselwano yonyango, enokutshintsha ngokuhamba kwexesha.
Imitha
Usebenzisa iipali zamandla ezinamandla amakhulu, unyango lwemitha lusetyenziselwa ukubulala iiseli zomhlaza kunye nokunciphisa amathumba. Ifuna ukuba ilele kakhulu phezu kwetafile ngelixa iipali zijolise kwindawo echanekileyo emzimbeni wakho.
Ukukhula kancinci, i-lymphoma yendawo, unyango lwe-radiation lunokuba yiyo yonke into oyifunayo.
Iziphumo ebezingalindelekanga zinokubandakanya ukudinwa kunye nokucaphuka kolusu.
Unyango ngamayeza
I-Chemotherapy yinkqubo yonyango enokuthi inikwe ngomlomo okanye ngaphakathi. Ezinye ii-lymphomas ezinobundlobongela zingaphiliswa nge-chemotherapy, ngakumbi kwisifo sokuqala.
I-DLBCL luhlobo olukhula ngokukhawuleza olunokunyangwa ngerejimeni yonyango ngamayeza ebizwa ngokuba yi-CHOP (cyclophosphamide, doxorubicin, vincristine, kunye ne-prednisone). Xa unikwa kunye ne-monoclonal antibody rituximab (Rituxan), ibizwa ngokuba yi-R-CHOP. Ihlala inikwa kwimijikelezo ngaphandle kweeveki ezininzi. Kunzima entliziyweni, ke ayisiyiyo inketho ukuba uneengxaki zentliziyo esele zikho.
Iziphumo zechemotherapy zinokubandakanya isicaphucaphu, ukudinwa, kunye nokulahleka kweenwele.
Unyango lomzimba
Amachiza e-Biologic anceda amajoni akho omzimba alwe nomhlaza. I-Rituximab ijolise kwiiproteni kumphezulu weeseli ze-B, isenza ukuba kube lula kumajoni omzimba ukuba awachonge kwaye awatshabalalise. Ngokunciphisa inani leeseli ezinomhlaza kunye nezisempilweni ze-B, iyeza linyusa umzimba wakho ukuba uvelise iiseli ze-B ezisempilweni. Oku kwenza ukuba kungabikho lula ukuba umhlaza uphinde ubuye.
Amayeza e-Radioimmunotherapy, anje nge-ibritumomab tiuxetan (Zevalin), enziwe ngamachiza omzimba omzimba ophethe iisotopu ezinemitha yeathom. Eli chiza linceda amajoni omzimba ancamathele kwiiseli zomhlaza ukuhanjiswa ngokuthe ngqo kwemitha.
Iziphumo ebezingalindelekanga zonyango lwe-immune zingabandakanya ukubalwa kweeseli ezimhlophe zegazi, ukudinwa kunye nosulelo.
Ukufakelwa kweseli
Ukufakelwa kweseli ye-stem kubandakanya ukufaka endaweni yomongo wethambo lakho kunye nomongo ovela kumnikeli osempilweni. Okokuqala, uyakufuna i-chemotherapy yedosi ephezulu okanye imitha yokucinezela amajoni akho omzimba, ukutshabalalisa iiseli zomhlaza, kunye nokwenza umongo omtsha. Ukuze ufaneleke, kuya kufuneka uphile ngokwaneleyo ukuze umelane nolu nyango.
Iziphumo ebezingalindelekanga zinokubandakanya usulelo, i-anemia, kunye nokwaliwa komongo wethambo omtsha.
Ngaba zikhona iingxaki?
IiLymphomas ziwenza buthathaka amajoni akho omzimba, zikwenze ube sesichengeni sokosuleleka. Ezinye iindlela zonyango lwe-lymphoma zingabangela iingxaki ezinjenge:
- ukungachumi
- Intliziyo, imiphunga, izintso, kunye nesifo se-thyroid
- isifo seswekile
- Umhlaza wesibini
I-B-cell lymphomas inokukhula kwaye isasazeke kwizitho ezikude.
Kunjani ukuchacha?
Ezinye iintlobo ze-B-cell lymphomas zinokunyangeka. Unyango lunokucothisa ukuqhubela phambili kwabanye. Ukuba akukho mqondiso womhlaza emva konyango lwakho oluphambili, oko kuthetha ukuba uxolelwe. Kusafuneka ulandele iminyaka eliqela ukubeka esweni ukuphindaphinda.
Imbonakalo
Isilinganiselo seminyaka emihlanu sokusinda kwi-non-Hodgkin's lymphoma ngama-70 eepesenti. Oku kwahluka kakhulu ngohlobo lwe-B-cell lymphoma kunye nenqanaba lokuxilongwa. Ezinye izinto eziqwalaselwayo yiminyaka yakho kunye nempilo iyonke.
Umzekelo, i-DLBCL iyanyangeka malunga nesiqingatha sabantu abanayo. Abo baqala unyango kumanqanaba angaphambili banombono ongcono kunabo banezifo ezisecaleni.
Ugqirha wakho unokukunikezela ngesimo sakho sonyango esisekwe kwiprofayili yakho yezempilo.
Iimpapasho Ezinomdla
Inaliti ye-Aprepitant / Fosaprepitant
