Umhlaza webele oPhucukileyo ngaphambi nasemva kokuyeka ukuya exesheni

Umxholo

• 1.Loluphi olona nyango luphambili lweehomoni ezinomhlaza webele ezifumana i-hormone?
• 2. Unyangwa njani umhlaza webele weemastastatic kwabasetyhini abangaphambi kokuyeka ukuya exesheni?
• 3. Luthini unyango olumiselweyo lwabasetyhini abasemva kokuba sexesheni?
• 4. Zisetyenziswa nini i-chemotherapy okanye unyango ekujoliswe kulo ukunyanga umhlaza wamabele?

Ushwankathelo

Umhlaza webele weMetastatic (obizwa ngokuba ngumhlaza webele osele uhambile) kuthetha ukuba umhlaza usasazekile ukusuka ebeleni uye kwezinye iindawo emzimbeni. Kusaqwalaselwa njengomhlaza wamabele kuba i-metastases inohlobo olufanayo lweeseli zomhlaza.

Ukhetho lonyango luxhomekeke kwiimpawu ezithile zethumba, ezinje ngokuba yi-hormone receptor-positive nokuba i-HER2-positive. Ezinye izinto zibandakanya impilo yangoku, naluphi na unyango okhe walifumana ngaphambili, kunye nokuba uthathe ixesha elingakanani ukuba umhlaza uphinde ubuye.

Unyango luxhomekeke ekubeni umhlaza usasazeke kangakanani kwaye nokuba sowudlulile ukuya exesheni. Nantsi eminye imibuzo oza kuyibuza ugqirha wakho malunga nomhlaza webele osele uhambile njengoko inxulumene nokuyeka ukuya exesheni.

1.Loluphi olona nyango luphambili lweehomoni ezinomhlaza webele ezifumana i-hormone?

Unyango lweHormonal, okanye unyango lwe-endocrine, luhlala luyinto ephambili kunyango lwabasetyhini abanesifo somhlaza webele. Ngamanye amaxesha kuthiwa unyango lwe-anti-hormone kuba lusebenza ngokungafaniyo nonyango lwe-hormone yonyango (HRT).

Injongo kukuthoba amanqanaba e-estrogen kunye neprogesterone emzimbeni ukuze kuthintele ezi hormone ukuba zingafumani iiseli zomhlaza kunye nokufumana i-estrogen ekufuneka ikhule.

Unyango lweHormonal lunokusetyenziselwa ukuphazamisa ifuthe lamahomoni ekukhuleni kweeseli kunye nokusebenza ngokubanzi. Ukuba iihomoni zivaliwe okanye zisuswe, iiseli zomhlaza azinakuphila.

Unyango lweHormonal luye luyeke iiseli zebele ezisempilweni ekufumaneni iihormoni ezinokukhuthaza iiseli ezinomhlaza ukuba ziphinde zibuye ngaphakathi ebeleni okanye kwenye indawo.

2. Unyangwa njani umhlaza webele weemastastatic kwabasetyhini abangaphambi kokuyeka ukuya exesheni?

Unyango lomhlaza webele lwe-Metastatic kubafazi be-premenopausal abanomdlavuza we-hormone receptor-positive zihlala zibandakanya uxinzelelo lwe-ovari. Le nkqubo yehlisa amanqanaba ehomoni emzimbeni ukuthintela ithumba le-estrogen ekufuneka ikhule.

Ukucinezelwa kwe-Ovarian kunokufezekiswa ngeendlela ezimbini:

• Amachiza anokuthintela ama-ovari ekwenzeni i-estrogen, ebangela ukuyeka ukuya exesheni kangangexesha elithile.
• Inkqubo yotyando ebizwa ngokuba yi-oophorectomy inokususa ii-ovari kwaye imise imveliso ye-estrogen ngokusisigxina.

I-aromatase inhibitor inokumiselwa kubafazi be-premenopausal ngokudibeneyo kunye noxinzelelo lwe-ovari. I-Aromatase inhibitors inokubandakanya:

• anastrozole (Arimidex)
• exemestane (Aromasin)
• ilerozole (Femara)

I-Tamoxifen, i-antiestrogen, ikwasetyenziswa ngokunyanga umhlaza webele we-metastatic kubasetyhini be-premenopausal. Unokuwuthintela umhlaza ekubuyeni okanye ekusasazeni kwenye indawo.

I-Tamoxifen ayinakuba lukhetho ukuba umhlaza uqhubekile kunyango lwangaphambili lwe-tamoxifen. Ukudibanisa uxinzelelo lwe-ovari kunye ne-tamoxifen kuye kwafunyanwa ukuphucula ukusinda xa kuthelekiswa ne-tamoxifen yodwa.

3. Luthini unyango olumiselweyo lwabasetyhini abasemva kokuba sexesheni?

Ukucinezelwa kwe-Ovarian akuyimfuneko kubafazi be-postmenopausal. Amaqanda abo sele eyekile ukwenza isixa esikhulu se-estrogen. Benza isixa esincinci kuphela kwizicwili zabo ezinamanqatha nakwiidrenal gland.

Unyango lwe-Postmenopausal hormone luhlala lubandakanya i-aromatase inhibitor. La machiza anciphisa inani le-estrogen emzimbeni ngokumisa izicwili kunye namalungu ngaphandle kwama-ovari ekwenzeni i-estrogen.

Iziphumo eziqhelekileyo ezichaphazelekayo ze-aromatase inhibitors ziquka:

• kushushu
• isicaphucaphu
• ukugabha
• amathambo abuhlungu okanye amalungu

Iziphumo ebezingalindelekanga ezimandundu ngakumbi zibandakanya ukunciphisa amathambo kunye nokwanda kwecholesterol.

Abafazi be-Postmenopausal banokumiselwa i-tamoxifen iminyaka eliqela, ihlala isihlanu okanye nangaphezulu. Ukuba ichiza lisetyenziselwa ixesha elingaphantsi kweminyaka emihlanu, iaromatase inhibitor ihlala inikwa iminyaka eseleyo.

Ezinye iziyobisi ezinokumiselwa zibandakanya ii-CDK4 / 6 inhibitors okanye i-fulvestrant.

4. Zisetyenziswa nini i-chemotherapy okanye unyango ekujoliswe kulo ukunyanga umhlaza wamabele?

I-Chemotherapy lolona khetho luphambili kunyango lwee-cancer zomhlaza zamabele eziphindwe kathathu (i-hormone receptor-negative kunye ne-HER2-negative). I-Chemotherapy inokusetyenziswa ngokudibeneyo ne-HER2 ejolise kunyango lwe-HER2-positive cancer cancer.

I-Chemotherapy inokusetyenziswa kwiimeko ezinobuzaza be-hormone receptor-positive, i-HER2-negative cancer.

Ukuba ichiza lokuqala le-chemotherapy, okanye indibaniselwano yamachiza, iyayeka ukusebenza kwaye umhlaza usasazeka, ichiza lesibini okanye lesithathu linokusetyenziswa.

Ukufumana unyango olufanelekileyo kunokuthatha uvavanyo kunye nephutha. Yintoni elungileyo komnye umntu ayizukufanelekela wena. Landela isicwangciso sakho sonyango kwaye unxibelelane nogqirha wakho. Bazise xa kukho into ethile okanye engasebenziyo.

Unokuba neentsuku ezinzima ngaphambili, kodwa kuyanceda ukwazi zonke iindlela zonyango onokuthi ukhethe kuzo.