Ukusilela kwefactor V

Ukusilela kwefactor V sisifo esophayo esidluliselwa kwiintsapho. Ichaphazela ukubanakho kwegazi ekunqandeni.

Ukujiya kwegazi yinkqubo entsonkothileyo ebandakanya uninzi lweeproteni ezingama-20 ezahlukeneyo kwiplasma. Ezi proteni zibizwa ngokuba zii-coagulation zegazi.

Ukusilela kwefactor V kubangelwa kukungabikho kwento V. Xa izinto ezithile zokuvala igazi ziphantsi okanye zilahlekile, igazi lakho alilihliki ngokufanelekileyo.

Ukusilela kwefactor V kunqabile. Ingabangelwa ngu:

• Into enesiphene V Uhlobo lofuzo oludluliselwe kwiintsapho (ezizuzwe njengelifa)
• I-antibody ephazamisa ukusebenza kwesiqhelo V

Unokuphuhlisa i-antibody ephazamisa umba we-V:

• Emva kokubeleka
• Emva kokuphathwa ngohlobo oluthile lweglu ye-fibrin
• Emva kotyando
• Ngezifo ezizimele kunye nomhlaza othile

Ngamanye amaxesha unobangela awaziwa.

Esi sifo sifana ne-hemophilia, ngaphandle kokuba ukuphuma kwamalungu kumalungu akuqhelekanga. Kwindlela yelifa lokunqongophala kwe-V, imbali yosapho yesifo sokopha yinto ebangela umngcipheko.

Ukopha kakhulu ngamaxesha okuya exesheni nasemva kokubeleka kudla ngokwenzeka. Ezinye iimpawu zingabandakanya:

• Ukopha kulusu
• Ukopha kweentsini
• Ukugruzuka okugqithisileyo
• Iimpumlo
• Ukulahleka kwegazi ixesha elide okanye okugqithileyo ngotyando okanye umothuko
• Isiphunzi esopha umbilical

Uvavanyo lokufumanisa ukusilela kwe-V lubandakanya:

• I-Factor V yolingo
• Uvavanyo lwegazi lokuvala, kubandakanya ixesha le-thromboplastin (PTT) kunye nexesha leprothrombin
• Ixesha lokopha

Uya kunikwa iplasma yegazi esitsha okanye ukumiliselwa kwe-plasma efriziwe qhwa ngexesha lokopha okanye emva kotyando. Olu nyango luya kulungisa ukusilela okwethutyana.

Imbonakalo ilungile ngoxilongo kunye nonyango olululo.

Ukopha ngamandla (ukopha) kunokwenzeka.

Yiya kwigumbi likaxakeka okanye utsalele umnxeba ku-911 okanye kwinombolo yongxamiseko yendawo ukuba uphulukene negazi ngokungachazwanga okanye ixesha elide.

Parahemophilia; Isifo somnini; Ukuphazamiseka kwegazi-ukusilela kwe-V

• Ukubumba kwegazi
• Amahlwili egazi

UGailani D, Wheeler AP, Neff AT. Ukunqongophala kwezinto ezinqabileyo. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 137.

Ragni MV. Ukuphazamiseka kwento eyophayo: ukungabikho kwento ekunqandeni. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 165.

UScott JP, uMkhukula VH. Ukusilela kwe-clotting factor factor (ukuphazamiseka kwegazi). Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahluko 503.