Uvavanyo lwe-BRAF Genetic

Umxholo

• Yintoni uvavanyo lwe-BRAF?
• Isetyenziselwa ntoni?
• Kutheni le nto ndifuna uvavanyo lwe-BRAF yemvelo?
• Kwenzeka ntoni ngexesha lovavanyo lwemfuzo lwe-BRAF?
• Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
• Ngaba bukhona ubungozi kuvavanyo?
• Zithetha ntoni iziphumo?
• Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweBRAF?
• Izalathiso

Yintoni uvavanyo lwe-BRAF?

Uvavanyo lwe-BRAF yemfuza lukhangela utshintsho, olubizwa ngokuba kukutshintsha, kwilungu elibizwa ngokuba yi-BRAF. Imfuza zizinto zokuqala ezisisiseko zofuzo ezidluliselwe zivela kunyoko nakuyihlo.

Uhlobo lwe-BRAF lwenza iprotein enceda ukulawula ukukhula kweseli. Yaziwa ngokuba yi-oncogene. I-oncogene isebenza njengokukhwela kwegesi emotweni. Ngokwesiqhelo, i-oncogene ijika ekukhuleni kweseli njengoko kufuneka. Kodwa ukuba unenguqu ye-BRAF, kufana nokuba i-pedal pedal ibambekile, kwaye ufuzo alunakumisa iiseli ekukhuleni. Ukukhula okungalawulwayo kweseli kunokukhokelela kumhlaza.

Uguquko lwe-BRAF lunokuzuzwa njengelifa kubazali bakho okanye lufunyenwe kamva ebomini. Utshintsho olwenzeka kamva ebomini zihlala zibangelwa yimeko-bume okanye yimpazamo eyenzeka emzimbeni wakho ngexesha lokwahlukana kweseli. Utshintsho olufunyenwe kwilifa le-BRAF lunqabile, kodwa kunokubangela iingxaki zempilo.

Ukufunyanwa (okwaziwa ngokuba yi-somatic) ukuguqulwa kwe-BRAF kuqheleke kakhulu. Olu tshintsho lufunyenwe phantse kwisiqingatha saso sonke isifo somhlaza wolusu. Ukuguqulwa kwe-BRAF kudla ngokufumaneka kwezinye iingxaki kunye neentlobo ezahlukeneyo zomhlaza, kubandakanya umhlaza wekolon, we-thyroid kunye nee-ovari. Umhlaza onotshintsho lwe-BRAF uhlala ubaluleke ngakumbi kunaleyo ingenakuguqulwa.

Amanye amagama: Uhlalutyo lokutshintsha kwemfuza lwe-BRAF, iMelanoma, i-BRAF V600 yotshintsho, icobas

Isetyenziselwa ntoni?

Uvavanyo luhlala lusetyenziselwa ukukhangela ukuguqulwa kwe-BRAF kwizigulana ezine-melanoma okanye ezinye i-cancer ezinxulumene ne-BRAF. Amayeza athile omhlaza asebenza ngakumbi kubantu abaneenguqu zeBRAF. La mayeza afanayo awasebenzi kwaye ngamanye amaxesha ayingozi kubantu abangenalo utshintsho.

Uvavanyo lwe-BRAF lungasetyenziselwa ukubona ukuba usemngciphekweni womhlaza osekwe kwimbali yosapho kunye / okanye kwimbali yakho yezempilo.

Kutheni le nto ndifuna uvavanyo lwe-BRAF yemvelo?

Unokufuna uvavanyo lwe-BRAF ukuba ufumene ukuba une-melanoma okanye olunye uhlobo lomhlaza. Ukwazi ukuba ngaba uguquko lunokunceda umboneleli wakho ukuba anike unyango olululo.

Unokulufuna olu vavanyo ukuze ubone ukuba usemngciphekweni omkhulu wokufumana umhlaza. Imiba yomngcipheko ibandakanya imbali yosapho yomhlaza kunye / okanye ukuba nomhlaza usemncinci. Ubudala obuthile buxhomekeke kuhlobo lomhlaza.

Kwenzeka ntoni ngexesha lovavanyo lwemfuzo lwe-BRAF?

Uninzi lweemvavanyo ze-BRAF zenziwa kwinkqubo ebizwa ngokuba yi-tumor biopsy. Ngexesha le-biopsy, umboneleli wokhathalelo lwempilo uyakukhupha iqhekeza elincinci ngokusika okanye ukukrwela umphezulu wethumba. Ukuba umboneleli wakho ufuna ukuvavanya izicwili zethumba ngaphakathi komzimba wakho, unokusebenzisa inaliti ekhethekileyo ukurhoxisa isampulu.

Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Ngokwesiqhelo awudingi malungiselelo akhethekileyo kuvavanyo lwe-BRAF.

Ngaba bukhona ubungozi kuvavanyo?

Unokuba nokugruzuka okuncinci okanye ukopha kwindawo ye-biopsy. Unokuba ungonwabi kwisiza usuku okanye ezimbini.

Zithetha ntoni iziphumo?

Ukuba une-melanoma okanye olunye uhlobo lomhlaza, kwaye iziphumo zibonisa ukuba une-BRAF mutation, umboneleli wakho unokuyalela amayeza ayilelwe ukujolisa kuguquko. La mayeza anokusebenza ngakumbi kunolunye unyango.

Ukuba une-melanoma okanye olunye uhlobo lomhlaza, kwaye iziphumo zikubonisa sukuyenza Utshintsho, umboneleli wakho uya kukuchazela iintlobo ezahlukeneyo zamayeza ukunyanga umhlaza wakho.

Ukuba awufumaniswanga ukuba unomdlavuza kwaye iziphumo zakho zibonisa ukuba une-BRAF yemfuza, oko ayi kuthetha ukuba unomhlaza, kodwa unengozi ephezulu yomhlaza. Kodwa ukuhlolwa komhlaza rhoqo, njengokuhlolwa kwesikhumba, kunokunciphisa umngcipheko. Ngexesha lovavanyo lolusu, umboneleli wezempilo uya kujonga ngononophelo kulusu lwakho kuwo wonke umzimba wakho ukujonga i-moles kunye nokunye ukukhula okukrokrisayo.

Thetha nomboneleli wakho ngamanye amanyathelo onokuwathatha ukunciphisa umngcipheko.

Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweBRAF?

Unokuva umboneleli wakho ethetha malunga notshintsho lwe-V600E. Kukho iintlobo ezahlukeneyo zokutshintsha kwe-BRAF. I-V600E lolona hlobo luqhelekileyo lokutshintsha kweBRAF.

Izalathiso

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Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.