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Umhla Wokudalwa: 12 Eyethupha 2021
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What is the role of high-dose melphalan with autologous stem cell transplant (ASCT) in 2017?
Ividiyo: What is the role of high-dose melphalan with autologous stem cell transplant (ASCT) in 2017?

Umxholo

I-Melphalan inokubangela ukwehla okukhulu kwinani leeseli zegazi kumongo wethambo lakho. Oku kunokubangela iimpawu ezithile kwaye kunokunyusa umngcipheko wokuba ube nosulelo olubi okanye ukopha. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngoko nangoko: umkhuhlane, umqala obuhlungu, ukukhohlela okuqhubekayo nokuxinana, okanye ezinye iimpawu zosulelo; ukopha okungaqhelekanga okanye ukugruzuka; enegazi okanye emnyama, ilindle; ukugabha kwegazi; okanye ukugabha igazi okanye izinto ezimdaka ezifana namabala ekofu.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo zaselebhu rhoqo ngaphambi kwaye ngexesha lonyango lwakho ukubona ukuba iiseli zakho zegazi ziyachaphazeleka kweli chiza.

I-Melphalan inokunyusa umngcipheko wokuba uphuhlise eminye imihlaza. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-melphalan.

IMelphalan isetyenziselwa ukunyanga i-myeloma emininzi (uhlobo lomhlaza womongo wethambo). IMelphalan ikwasetyenziselwa ukunyanga uhlobo oluthile lomhlaza we-ovari (umhlaza oqala kumalungu okuzala awasetyhini apho kwenziwa khona amaqanda). UMelphalan ukwiklasi yamayeza abizwa ngokuba ziiarhente ze-alkylating. Isebenza ngokumisa okanye ukunciphisa ukukhula kweeseli zomhlaza emzimbeni wakho.


IMelphalan iza njengecwecwe lokuthatha ngomlomo. Ngokuqhelekileyo kuthathwa kwisisu esingenalutho kanye ngosuku. Ubude bonyango buxhomekeke kwiintlobo zamachiza owathathayo, ukuba umzimba wakho uphendula njani kuwo, kunye nohlobo lomhlaza onawo. Thatha i-melphalan ngokujikeleza ixesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-melphalan ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokufuna ukulibazisa unyango lwakho okanye uhlengahlengise idosi ye-melphalan kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Sukuyeka ukuthatha i-melphalan ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

I-Melphalan ngamanye amaxesha isetyenziselwa ukunyanga umhlaza wamabele. Ngamanye amaxesha kusetyenziswa ukunyanga i-amyloidosis (isifo apho iiproteni ezingaqhelekanga zakha izicwili kunye namalungu emzimbeni). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.


Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-melphalan,

  • xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-melphalan, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-melphalan Buza usokhemesti wakho uluhlu lwezithako.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: carmustine (BICNU, BCNU), cimetidine (Tagamet), cisplatin (Platinol AQ), cyclosporine (Sandimmune, Gengraf, Neoral), okanye interferon alfa (Intron A, Infergen, Alferon N).
  • xelela ugqirha wakho ukuba uthathe i-melphalan ngaphambili, kodwa umhlaza wakho awuphendulanga kunyango. Ugqirha wakho uya kukuxelela ukuba ungathathi i-melphalan.
  • xelela ugqirha wakho ukuba ufumene unyango ngemitha okanye enye ichemotherapy kutshanje okanye ukuba unesifo sezintso.
  • Kuya kufuneka uyazi ukuba i-melphalan inokuphazamisa umjikelo oqhelekileyo wokuya exesheni (ixesha) kubafazi kwaye inokuyeka okwethutyana okanye ngokusisigxina ukuyeka ukuvelisa isidoda emadodeni. I-Melphalan inokubangela ukungachumi (ubunzima bokukhulelwa); Nangona kunjalo, akufuneki ucinge ukuba awungekhe ukhulelwe okanye awungekhe umithise omnye umntu. Abasetyhini abakhulelweyo okanye abancancisayo kufuneka baxelele oogqirha babo ngaphambi kokuba baqale ukusebenzisa eli chiza. Akufanele ucwangcise ukuba nabantwana ngelixa ufumana i-chemotherapy okanye okwethutyana emva konyango. (Thetha nogqirha wakho ukuze ufumane iinkcukacha ezithe vetshe.) Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukuthintela ukukhulelwa. IMelphalan inokulimaza umbungu.
  • awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Melphalan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukugabha
  • ukuphelelwa ngumdla wokutya okanye ubunzima
  • izilonda emlonyeni nasemqaleni
  • ukuphoswa lixesha lokuya exesheni (kumantombazana nabasetyhini)
  • ngokudibeneyo, umsipha, okanye iintlungu zomqolo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

  • irhashalala
  • urhwebo
  • ukurhawuzelela
  • ubunzima bokuphefumla okanye ukugwinya
  • ulusu oluthuthu
  • ukudinwa kakhulu
  • isiqaqa
  • ngokukhawuleza, ngokungaqhelekanga, okanye ukubetha kwentliziyo
  • mthubi ulusu okanye amehlo
  • iintlungu kwinxalenye ephezulu yesisu
  • umchamo omnyama ngombala
  • amaqhuma angaqhelekanga okanye ubunzima

I-Melphalan inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina kwifriji kwaye kude nokukhanya.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

  • ukugabha
  • urhudo
  • izilonda emlonyeni nasemqaleni
  • emnyama, ilindile, okanye ilindle eligazi
  • ukugabha kwegazi okanye into egabileyo ebonakala ngathi yindawo yekhofi
  • ukugruzuka okanye ukopha okungaqhelekanga
  • umqala obuhlungu, ukukhohlela, umkhuhlane, okanye ezinye iimpawu zosulelo

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • IAlkeran® Amacwecwe
  • I-phenylalanine lwesardard
Ukuhlaziywa kokugqibela-05/15/2017

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