Umbhali: Virginia Floyd
Umhla Wokudalwa: 5 Eyethupha 2021
Hlaziya Umhla: 23 Eyedwarha 2024
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Утепление хрущевки. Переделка хрущевки от А до Я  #6. Теплоизоляция квартиры.
Ividiyo: Утепление хрущевки. Переделка хрущевки от А до Я #6. Теплоизоляция квартиры.

Umxholo

Yintoni uvavanyo lwe-BRCA yemfuza?

Uvavanyo lwe-BRCA lwemfuza lujonga utshintsho, olwaziwa njengeenguqulelo, kwiijeni ezibizwa ngokuba yi-BRCA1 kunye ne-BRCA2. Imfuza ngamalungu e-DNA agqithiselwe kumama notata wakho. Baphethe ulwazi oluchaza iimpawu zakho ezizodwa, ezinjengokuphakama nombala wamehlo. Imfuza ikwanoxanduva lweemeko ezithile zempilo. I-BRCA1 kunye ne-BRCA2 ziijeni ezikhusela iiseli ngokwenza iiproteni ezinceda ukukhusela amathumba ekubeni enze.

Utshintsho kwi-BRCA1 okanye i-BRCA2 yemfuza inokubangela ukonakala kweseli okungakhokelela kumhlaza. Abasetyhini abane-BRCA yemfuza eguqulweyo banomngcipheko ophezulu wokufumana umhlaza webele okanye we-ovari. Amadoda ane-gene ye-BRCA eguqulweyo asemngciphekweni omkhulu wokufumana umhlaza webele okanye webele. Asinguye wonke umntu ozuza njengelifa i-BRCA1 okanye i-BRCA2 utshintsho oluza kuba nomhlaza. Ezinye izinto, kubandakanya indlela ophila ngayo kunye nokusingqongileyo, inokuchaphazela umngcipheko womhlaza wakho.

Ukuba ufumanisa ukuba une-BRCA mutation, unganakho ukuthatha amanyathelo okukhusela impilo yakho.

Amanye amagama: Uvavanyo lwe-BRCA yemfuza, i-BRCA ye-gene 1, i-BRCA yemfuza yesi-2, isifo somhlaza wamabele osisifo se-gene1, isifo somhlaza wamabele osulelo lwe-gene 2


Isetyenziselwa ntoni?

Olu vavanyo lusetyenziselwa ukufumanisa ukuba une-BRCA1 okanye i-BRCA2 gene. Ukuguqulwa kwemfuza ye-BRCA kunokunyusa umngcipheko wokuba nomhlaza.

Kutheni le nto ndifuna uvavanyo lwe-BRCA yemvelo?

Uvavanyo lwe-BRCA alukhuthazwanga kubantu abaninzi. Ukutshintsha kwemfuza ye-BRCA kunqabile, kuchaphazela kuphela iipesenti ezi-0.2 zabemi base-US. Kodwa unokufuna olu vavanyo ukuba ucinga ukuba usemngciphekweni omkhulu wokuguquka. Kungenzeka ukuba ube ne-BRCA utshintsho xa:

  • Unomdlavuza webele oye wafunyanwa ngaphambi kweminyaka engama-50
  • Unayo okanye unomdlavuza webele kumabele amabini
  • Unomhlaza wamabele kunye nowesibeleko
  • Unelungu elinye okanye amalungu osapho anomdlavuza webele
  • Unesihlobo sendoda esinomhlaza webele
  • Unesihlobo esele sifumene isifo se-BRCA
  • Ngaba zeAshkenazi (eMpuma Yurophu) ngamaJuda. Utshintsho lwe-BRCA luxhaphake kakhulu kweli qela xa kuthelekiswa noluntu ngokubanzi. Utshintsho lwe-BRCA luxhaphake kakhulu kubantu abavela kwezinye iindawo zaseYurophu, kubandakanya i-Iceland, iNorway, neDenmark.

Kwenzeka ntoni ngexesha lovavanyo lwemfuzo lwe-BRCA?

Ingcali yokhathalelo lwempilo iyakuthatha isampulu yegazi kumthambo engalweni yakho, isebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.


Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Awudingi naluphi na ulungiselelo olukhethekileyo lovavanyo lwe-BRCA. Kodwa unokufuna ukudibana nomcebisi wezofuzo kuqala ukuze ubone ukuba ngaba uvavanyo lulungile na kuwe. Umcebisi wakho angathetha nawe malunga nomngcipheko kunye nezibonelelo zovavanyo lofuzo kunye nokuba zeziphi iziphumo ezahlukeneyo ezinokuthetha.

Kuya kufuneka ucinge malunga nokufumana iingcebiso ngemfuzo emva kovavanyo lwakho. Umcebisi wakho unokuxoxa ngendlela iziphumo zakho ezinokuthi zichaphazele ngayo wena kunye nosapho lwakho, kwezonyango nangokweemvakalelo.

Ngaba bukhona ubungozi kuvavanyo?

Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.

Zithetha ntoni iziphumo?

Uninzi lweziphumo zichazwa njengezingalunganga, ezingaqinisekanga, okanye ezilungileyo, kwaye zithetha oku kulandelayo:

  • Iziphumo ezingalunganga kuthetha ukuba akukho BRCA uguquko lufunyenwe, kodwa oko akuthethi ukuba awusoze ufumane umhlaza.
  • Isiphumo esingaqinisekanga kuthetha ukuba uhlobo oluthile lokuguqulwa kwemfuza lwe-BRCA lufunyenwe, kodwa kunokuba okanye kunganxulunyaniswa nokwanda komngcipheko womhlaza. Unokufuna iimvavanyo ezingaphezulu kunye / okanye ukubeka esweni ukuba iziphumo zakho bezingaqinisekanga.
  • Iziphumo ezilungileyo Kuthetha utshintsho kwi-BRCA1 okanye kwi-BRCA2. Olu tshintsho lukubeka emngciphekweni omkhulu wokufumana umhlaza. Kodwa ayinguye wonke umntu onguquko ofumana umhlaza.

Kungathatha iiveki ezininzi ukufumana iziphumo zakho. Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo kunye / okanye umcebisi wezofuzo.


Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwemfuzo lwe-BRCA?

Ukuba iziphumo zakho zibonisa ukuba une-BRCA gene, unokuthatha amanyathelo anokunciphisa umngcipheko womhlaza wamabele. Oku kubandakanya:

  • Uvavanyo lokuvavanywa komhlaza rhoqo, ezinje ngee-mammograms kunye nee-ultrasound. Umhlaza kulula ukunyanga xa ufumaneka kumanqanaba okuqala.
  • Ukuthatha iipilisi zolawulo lokuzalwa okwethutyana. Ukuthatha iipilisi zolawulo lokuzalwa kangangeminyaka emihlanu kuye kwaboniswa ukunciphisa umngcipheko womhlaza wesibeleko kwabanye abantu basetyhini abane-BRCA gene. Ukuthatha iipilisi ngaphezulu kweminyaka emihlanu ukunciphisa umhlaza akukhuthazwa. Ukuba ubusela iipilisi zolawulo lokuzalwa ngaphambi kokuba uthathe uvavanyo lwe-BRCA, xelela umboneleli wakho wezempilo ukuba wawumdala kangakanani xa uqala ukuthatha iipilisi kwaye uhlala ixesha elingakanani. Uya kuthi emva koko acebise ukuba kuya kufuneka uqhubeke uzithathe okanye hayi.
  • Ukuthatha amayeza alwa nomhlaza. Amanye amachiza, anje ngokuba abizwa ngokuba yi-tamoxifen, abonakalisiwe ukunciphisa umngcipheko kubafazi abanomngcipheko ophezulu womhlaza wamabele.
  • Ukwenza utyando, okwaziwa njenge-mastectomy yokuthintela, ukususa izicubu zamabele ezisempilweni. Uthintelo lwe-mastectomy lubonakalisile ukunciphisa umngcipheko womhlaza webele malunga neepesenti ezingama-90 kwabasetyhini abane-BRCA gene. Kodwa lo ngumsebenzi ophambili, kucetyiswa kuphela abasetyhini abasemngciphekweni omkhulu wokufumana umhlaza.

Kuya kufuneka uthethe nomboneleli wakho wezempilo ukuze ubone ukuba ngawaphi amanyathelo akulungeleyo.

Izalathiso

  1. Umbutho waseMelika we-Oncology yeklinikhi [kwi-Intanethi]. Umbutho waseMelika woNyango lweZonyango; U-2005-2018. Isifuba esifubeni kunye ne-Ovarian Cancer; [icatshulwe ngo-2018 nge-19 kaMatshi]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.cancer.net/cancer-types/hereditary-breast-and-ovarian-cancer
  2. UHinkle J, uCheever K. Brunner kunye neSuddarth's Handbook yeLebhu kunye noVavanyo lokuChonga. 2nd Ed, Kindle. IPhiladelphia: Impilo yeWolters Kluwer, uLippincott Williams kunye noWilkins; Ngowama-2014. Uvavanyo lwe-BRCA; 108 iphe.
  3. Uvavanyo lweLebhu kwi-Intanethi [kwi-Intanethi]. IWashington DC: Umbutho waseMelika weKlinikhi yeKhemistry; c2001–2018. Uvavanyo lwe-BRCA Gene Muting Testing [luhlaziywe ngo-2018 Jan 15; icatshulwe ngo-2018 Feb 23]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://labtestsonline.org/tests/brca-gene-mutation-testing
  4. Ikliniki yaseMayo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2018. Uvavanyo lwe-BRCA yemfuza yomngcipheko webele kunye ne-ovari yomhlaza; 2017 Disemba 30 [icatshulwe ngowama-2018 Feb 23]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.mayoclinic.org/tests-procedures/brca-gene-test/about/pac-20384815
  5. Iziko loMhlaza weSikhumbuzo seSeleni Sloan [Internet]. ENew York: iZiko loMhlaza leCettering Cancer Centre; c2018. I-BRCA1 kunye ne-BRCA2 iGenesis: Umngcipheko woMhlaza weSifuba kunye ne-Ovarian [ucatshulwe ngo-2018 uFebruwari 23]; [malunga nezikrini ezi-5]. Ifumaneka kwi: https://www.mskcc.org/cancer-care/risk-assessment-screening/hereditary-genetics/genetic-counselling/brca1-brca2-genes-risk-breast-ovarian
  6. IZiko leSizwe loMhlaza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Utshintsho lwe-BRCA: Umngcipheko woMhlaza kunye novavanyo lweMfuzo [icatshulwe ngo-2018 ngoFebruwari 23]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet#q1
  7. IZiko leSizwe loMhlaza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Isichazi-magama seNCI seMiqathango yoMhlaza: utshintsho [olucatshulwe ngo-2018 ngoFebruwari 23]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=mutation
  8. Intliziyo kaZwelonke, iMiphunga, kunye neZiko leGazi [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Uvavanyo lwegazi [lukhankanywe ngo-2018 Feb 23]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.nhlbi.nih.gov/health-topics/blood-tests
  9. I-NIH yeLayibrari yeSizwe yoNyango yezeMpilo: Isalathiso seKhaya leMfuza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Uhlobo lwe-BRCA1; 2018 Mar 13 [icatshulwe ngo-2018 nge-18 kaMatshi]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://ghr.nlm.nih.gov/gene/BRCA1#imeko
  10. I-NIH yeLayibrari yeSizwe yoNyango yezeMpilo: Isalathiso seKhaya leMfuza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Uhlobo lwe-BRCA2; 2018 Mar 13 [icatshulwe ngo-2018 nge-18 kaMatshi]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://ghr.nlm.nih.gov/gene/BRCA2#imeko
  11. I-NIH yeLayibrari yeSizwe yoNyango yezeMpilo: Isalathiso seKhaya leMfuza [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Yintoni ufuzo ?; 2018 Feb 20 [icatshulwe ngowama-2018 Feb 23]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://ghr.nlm.nih.gov/primer/basics/gene
  12. IYunivesithi yaseRochester Medical Centre [i-Intanethi]. URochester (NY): KwiYunivesithi yaseRochester Medical Centre; c2018. I-Encyclopedia Yezempilo: I-BRCA [icatshulwe ngo-2018 ngoFebruwari 23]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid;=brca
  13. Ezempilo ze-UW [kwi-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2018. Umhlaza wamabele (i-BRCA) Uvavanyo lwe-Gene: Ungazilungiselela njani [zihlaziyiwe ngo-2017 Jun 8; icatshulwe ngo-2018 Feb 23]; [malunga nezikrini ezi-5]. Ifumaneka kwi: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6465
  14. Ezempilo ze-UW [kwi-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2018. Umhlaza Wamabele (BRCA) Uvavanyo lwe-Gene: Iziphumo [zihlaziyiwe ngo-2017 Jun 8; icatshulwe ngo-2018 Feb 23]; [malunga nezikrini ezili-9]. Ifumaneka kwi: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu6469
  15. Ezempilo ze-UW [kwi-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2018. Umhlaza wamabele (i-BRCA) Uvavanyo lwe-Gene: Uvavanyo lwesishwankathelo [luhlaziyiwe ngo-2017 Jun 8; icatshulwe ngo-2018 Feb 23]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html
  16. Ezempilo ze-UW [kwi-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2018. Umhlaza webele (i-BRCA) Uvavanyo lwe-Gene: Kutheni lwenziwe [luhlaziyiwe ngo-2017 Jun 8; icatshulwe ngo-2018 Feb 23]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://www.uwhealth.org/health/topic/medicaltest/breast-cancer-brca-gene-test/tu6462.html#tu646

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