IClopidogrel, iThebhulethi yomlomo

Umxholo

• Amagqabantshintshi eclopidogrel
• Yintoni iclopidogrel?
• Kutheni isetyenziswa
• Ingaba isebenza kanjani
• Iziphumo ebezingalindelekanga zeClopidogrel
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• IClopidogrel inokusebenzisana namanye amayeza
• Isifo seswekile
• Iziyobisi zesisu esiswini (iproton pump inhibitors)
• Izidakamizwa ezichasayo ezichasayo (i-NSAID)
• Abacoci begazi
• Iziyobisi ezisetyenziselwa ukunyanga uxinzelelo
• Isalicylates (aspirin)
• Iipioids
• Ungayithatha njani iclopidogrel
• Iifom kunye namandla
• Umyinge wesifo se-coronary syndrome
• Isisombululo sokuhlaselwa kwentliziyo kwangoko, ukubetha kwangoku, okanye isifo se-peripheral arterial
• Izilumkiso zeClopidogrel
• Isilumkiso se-FDA: Isilumkiso somsebenzi wesibindi
  
• Isilumkiso sokopha kakhulu
• Isilumkiso sotyando okanye inkqubo
• Isilumkiso somzimba
• Ukudibana kotywala
• Izilumkiso zabantu abaneemeko ezithile zempilo
• Izilumkiso kwamanye amaqela
• Thatha njengoko kuyalelwe
• Ukuqwalaselwa okubalulekileyo kokuthatha i-clopidogrel
• Ngokubanzi
• Ukugcina
• Ukuhamba
• Ukuzilawula
• Ukubeka iliso kwezonyango
• Iindleko ezifihliweyo
• Ukufumaneka
• Ngaba zikhona ezinye iindlela?

Amagqabantshintshi eclopidogrel

1. Ithebhulethi yomlomo yeClopidogrel iyafumaneka njengamachiza enziwe afana nalawo enziwa ngumenzi nethiwa. Igama lebrand: Plavix.
2. IClopidogrel iza kuphela kwifom yepilisi oyithatha ngomlomo.
3. IClopidogrel isetyenziselwa ukuthintela ukubetha kwentliziyo kunye nokubetha. Imiselwe abantu abaye bahlaselwa sisifo sentliziyo okanye ukubetha, okanye abanesifo sephepha lomzimba (ukujikeleza okungalunganga emilenzeni).

Yintoni iclopidogrel?

Ithebhulethi yomlomo yeClopidogrel sisiyobisi esikho njengesiyobisi segama lophawu IPlavix. Ikwafumaneka njengechiza elenza la machiza. Amachiza enziwe afana nalawo aveliswe ngumenzi ahlala exabisa ixabiso lawo kunexabiso lawo. Ngamanye amaxesha, azinakufumaneka kuwo onke amandla okanye iifom njengegama legama lophawu.

IClopidogrel iza kuphela kwifom yepilisi oyithatha ngomlomo.

Kutheni isetyenziswa

I-Clopidogrel isetyenziselwa ukunqanda amahlwili egazi xa unentlungu esifubeni, isifo semithambo esembindini (ukungahambi kakuhle emilenzeni), isifo sentliziyo, okanye ukubetha.

Eli chiza linokusetyenziswa njengenxalenye yonyango oludibeneyo. Oko kuthetha ukuba unokufuna ukuyithatha kunye nezinye iziyobisi. Ugqirha wakho uya kuthatha isigqibo sokuba ngaba kufanelekile ukusebenzisa eli chiza kunye nezinye iziyobisi, njengeasprini.

Ingaba isebenza kanjani

I-Clopidogrel yeyeklasi yamachiza abizwa ngokuba yi-platelet inhibitors okanye thienopyridine class inhibitors ye-P2Y12 ADP receptors. Iklasi leziyobisi liqela lamayeza asebenza ngendlela efanayo. La machiza ahlala esetyenziselwa ukunyanga iimeko ezifanayo.

Iiplatelets ziiseli zegazi ezinceda igazi lakho ukuba lijiye ngesiqhelo. I-Clopidogrel inceda ukuthintela iiplatelets ekuncamathelaneni. Oku kuyabanqanda ekwenzeni amahlwili egazi.

Iziphumo ebezingalindelekanga zeClopidogrel

Ithebhulethi yomlomo yeClopidogrel inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha i-clopidogrel. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeclopidogrel, okanye iingcebiso ngendlela yokujongana nefuthe elibi, thetha nogqirha okanye usokhemesti.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo ezinokubakho nge-clopidogrel zibandakanya:

• ukopha
• ukurhawuzelela ulusu

Ukuba unesikhumba esirhawuzelelayo, sinokuhamba ngaphakathi kweentsuku ezimbalwa okanye kwiiveki ezimbalwa. Ukuba kunzima kakhulu okanye akupheli, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka. Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

• Ukopha okumandundu, okusongela ubomi. Iimpawu zingabandakanya:
  • Ukopha okungachazwanga okanye ukopha okuhlala ixesha elide
  • igazi kumchamo wakho (upinki, obomvu, okanye umbala omdaka ngombala)
  • izitulo ezibomvu okanye ezimnyama ezibonakala ngathi zi-tar
  • Imivumbo engachazwanga okanye imivumbo ekhula ngokuba nkulu
  • ukukhohlela igazi okanye amahlwili egazi
  • ukugabha igazi okanye ukugabha okujongeka njengendawo yekofu
• Ingxaki yokunqanda igazi ebizwa ngokuba yi-thrombotic thrombocytopenic purpura (TTP). Le meko inokwenzeka emva kokuba uthathe i-clopidogrel, nokuba uyithatha kuphela kwisithuba esingaphantsi kweeveki ezimbini. Kwi-TTP, amahlwili egazi kwifom yegazi naphina emzimbeni. Fumana uncedo lwezonyango kwangoko ukuba unayo nayiphi na le mpawu:
  • Amabala abomvu (purpura) kulusu lwakho okanye emlonyeni wakho (inwebu yangaphakathi) ngenxa yokopha phantsi kolusu
  • ukutyheli kolusu lwakho okanye abamhlophe bamehlo akho (i-jaundice)
  • ukudinwa okanye ubuthathaka
  • ulusu olukhangeleke ngombala
  • ifiva
  • ukukhawuleza kwentliziyo okanye ukuphefumla kancinci
  • intloko ebuhlungu
  • unengxaki yokuthetha okanye ukuqonda ulwimi (aphasia)
  • ukudideka
  • ikhoma
  • ukubetha
  • ukuxhuzula
  • umchamo omncinci, okanye umchamo lowo upinki okanye unegazi
  • isisu esibuhlungu
  • isicaphucaphu, ukugabha, okanye urhudo
  • ukulahleka kombono

IClopidogrel inokusebenzisana namanye amayeza

Ithebhulethi yomlomo yeClopidogrel inokusebenzisana namanye amayeza. Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, ezinye zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela ukwanda kweempembelelo.

Apha ngezantsi luluhlu lwamayeza anokusebenzisana ne-clopidogrel. Olu luhlu alunazo zonke iziyobisi ezinokusebenzisana ne-clopidogrel.

Ngaphambi kokuba uthathe i-clopidogrel, qiniseka ukuxelela ugqirha wakho kunye nosokhemesti ngayo yonke into emiselweyo, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Isifo seswekile

Kwiimeko ezininzi, ipharamikhi akufuneki ithathwe nge-clopidogrel. Ukuthatha la mayeza kunye kukonyusa inani le-repaglinide emzimbeni wakho, kunokubangela amanqanaba eswekile esezantsi egazini. Ukuba kufuneka uthathe la machiza kunye, ugqirha wakho uya kuyilawula ngononophelo idosi yakho ye-repaglinide.

Iziyobisi zesisu esiswini (iproton pump inhibitors)

Akufanele uthathe i-clopidogrel ngamachiza asetyenziselwa ukunyanga isisu esiswini. Banokwenza ukuba i-clopidogrel isebenze kancinci. Imizekelo yala machiza ibandakanya:

• omeprazole
• ukulele

Izidakamizwa ezichasayo ezichasayo (i-NSAID)

Ukuthatha i-clopidogrel kunye nee-NSAID kunokunyusa umngcipheko wokopha esiswini kunye nasemathumbu. Imizekelo yala machiza ibandakanya:

• Iasprini
• ibuprofen
• iqeqsha

Abacoci begazi

IWarfarin kunye nomsebenzi we-clopidogrel wokunciphisa igazi ngeendlela ezahlukeneyo. Ukuzithatha kunye kwandisa umngcipheko wokopha.

Iziyobisi ezisetyenziselwa ukunyanga uxinzelelo

Sebenzisa i-anti-depressants ethile nge-clopidogrel kunokunyusa umngcipheko wokopha. Imizekelo yala machiza ibandakanya:

• i-serotonin reuptake inhibitors ekhethiweyo (SSRIs)
• i-serotonin-norepinephrine reuptake inhibitors (SNRIs)

Isalicylates (aspirin)

Ukuba une-acon coronary syndrome, kuya kufuneka uthathe i-aspirin kunye ne-clopidogrel. Nangona kunjalo, akufuneki uthathe la machiza kunye ukuba ubusandula ukubetha. Ukwenza njalo kwandisa umngcipheko wokuphuma kwegazi.

Iipioids

Ukuthatha iyeza le-opioid kunye ne-clopidogrel kunokulibazisa ukufunxwa kunye nokunciphisa inani le-clopidogrel emzimbeni wakho, ukuyenza ingasebenzi kakuhle. Ukuba kufuneka uwathathe kunye la machiza, ugqirha wakho unokukunika amayeza ongezelelweyo ukukunceda ukuthintela amahlwili egazi kwiimeko ezithile.

Imizekelo yeeopioid ibandakanya:

• ikhowudi
• hydrocodone
• fentanyl
• Imofini

Ungayithatha njani iclopidogrel

Umthamo we-clopidogrel ogqirha ugqirha wakho aya kuxhomekeka kuhlobo lwesimo osisebenzisayo ukunyanga.

Ngokuqhelekileyo, ugqirha wakho uya kukuqala kwiqondo eliphantsi kwaye ulungelelanise ixesha elide ukufikelela kumthamo olungele wena. Ekugqibeleni baya kumisela idosi encinci enika isiphumo esifunekayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom kunye namandla

Ngokwesiqhelo: Clopidogrel

• Ifom: ithebhulethi yomlomo
• Amandla: 75 mg kunye 300 mg

Igama lebrand: IPlavix

• Ifom: ithebhulethi yomlomo
• Amandla: 75 mg kunye 300 mg

Umyinge wesifo se-coronary syndrome

Umthamo wabantu abadala (abaneminyaka eli-18 nangaphezulu)

• Isiqalo sokuqala sokuqala: I-300 mg, ithathe ixesha elinye. Ukuqala unyango ngaphandle kwethamo lokulayisha kuya kulibazisa iziphumo ngeentsuku ezininzi.
• Umthamo wesondlo: 75 mg, ithathwa kanye ngemini.

Idosi yomntwana (iminyaka eyi-0 ukuya kwi-17 iminyaka)

Eli chiza alifundiswanga ebantwaneni kwaye akufuneki lisetyenziswe kubantu abangaphantsi kweminyaka eli-18.

Isisombululo sokuhlaselwa kwentliziyo kwangoko, ukubetha kwangoku, okanye isifo se-peripheral arterial

Umthamo wabantu abadala (abaneminyaka eli-18 nangaphezulu)

• Umyinge oqhelekileyo: I-75 mg ithathwa kanye ngemini.

Idosi yomntwana (iminyaka eyi-0 ukuya kwi-17 iminyaka)

Eli chiza alifundiswanga ebantwaneni kwaye akufuneki lisetyenziswe kubantu abangaphantsi kweminyaka eli-18.

Izilumkiso zeClopidogrel

Isilumkiso se-FDA: Isilumkiso somsebenzi wesibindi

• Eli chiza linesiLumkiso seBhokisi emnyama. Esi sisilumkiso esibi kakhulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso sebhokisi emnyama silumkisa oogqirha kunye nezigulana ngeziphumo ezinobungozi.
• I-Clopidogrel idilizwe sisibindi sakho. Abanye abantu banomahluko kwimfuza kwindlela enye yee-enzyme zesibindi, i-cytochrome p-450 2C19 (CYP2C19), esebenza ngayo. Oku kunokucothisa indlela eli chiza elophuke ngayo emzimbeni wakho kwaye lenze ukuba lingasebenzi ngokunjalo. Ugqirha wakho angakuvavanya ukuze ubone ukuba awunawo umahluko wemfuza. Ukuba unayo, ugqirha wakho uya kukuyalela ezinye iindlela zonyango okanye iziyobisi endaweni yeclopidogrel.

Isilumkiso sokopha kakhulu

Eli chiza linokubangela ukopha kakhulu kwaye ngamanye amaxesha kuyabulala. IClopidogrel inokukwenza utyumke kwaye wophe ngokulula, ube neempumlo, kwaye kuya kuthatha ixesha elide kunesiqhelo ukopha kuyeke. Kuya kufuneka uxelele ugqirha wakho malunga nokuphuma kwegazi okunzulu, njenge:

• ukuphuma kwegazi okungachazwanga, ixesha elide, okanye ukugqitha
• igazi kumchamo wakho okanye isitulo

Isilumkiso sotyando okanye inkqubo

Ngaphambi kokuba kwenziwe nayiphi na inkqubo, kuya kufuneka uxelele oogqirha okanye oogqirha bamazinyo ukuba uthatha i-clopidogrel. Kuya kufuneka uyeke ukuthatha eli chiza okwexeshana ngaphambi kwenkqubo yokuthintela ukopha. Ugqirha wakho uya kukwazisa ukuba uyeke nini ukuthatha la mayeza kwaye xa kulungile ukuba uphinde uwathathe.

Isilumkiso somzimba

I-Clopidogrel inokubangela ukusabela okugwenxa. Iimpawu zingabandakanya:

• ingxaki yokuphefumla
• ukudumba kobuso bakho, imilebe, ulwimi, okanye umqala

Sukuphinda ulithathe eli chiza ukuba ukhe waba negazi kulo. Kananjalo akufuneki ukuba uthathe eli chiza ukuba uxabisa i-thienopyridines (njenge-ticlopidine kunye ne-clopidogrel). Ukuyithatha okwesibini emva kokuphendula okungafunekiyo kunokuba yingozi.

Ukudibana kotywala

Utywala bunokunyusa umngcipheko wokopha ngelixa uthatha eli chiza.

Izilumkiso zabantu abaneemeko ezithile zempilo

Kubantu abopha ngokusebenzayo: Akufanele uthathe i-clopidogrel ukuba wopha ngokufayo (njengegazi lobuchopho) okanye imeko yezonyango ebangela ukopha (njengesisu okanye isilonda samathumbu). I-Clopidogrel ithintela ukujiya kwaye yonyuse umngcipheko wokopha.

Kubantu abanesifo sokungabikho komzimba kwi-thienopyridines: Ukuba wakha waba negalelo nakuluphi na uhlobo lwe-thienopyridine, akufuneki uthathe i-clopidogrel.

Kubantu abane-stroke esandula ukwenzeka: Akufanele uthathe eli chiza kunye neasprini ukuba usandula ukubetha. Inokunyusa umngcipheko wokopha kakhulu.

Izilumkiso kwamanye amaqela

Abafazi abakhulelweyo: Izifundo ezenziwa kwabasetyhini abakhulelweyo abathatha i-clopidogrel khange zibonise umngcipheko okhulayo wokukhubazeka kokuzalwa okanye ukuphuma kwesisu. Izifundo ze-clopidogrel kwizilwanyana ezikhulelweyo azibonisanga mngcipheko.

Nangona kunjalo, kunokwenzeka ukuba kubekho umngcipheko kumama nakwimveku engekazalwa ukuba isifo sentliziyo okanye ukubetha kwenzeka ngexesha lokukhulelwa. Ke ngoko, isibonelelo se-clopidogrel ekuthinteleni le micimbi yempilo sinokugqitha kuwo nawuphi na umngcipheko wechiza ekukhulelweni.

Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. IClopidogrel kufuneka isetyenziswe ngexesha lokukhulelwa kuphela ukuba isibonelelo esinokubakho siqinisekisa umngcipheko onokubakho.

Kubafazi abancancisayo: Ayaziwa ukuba i-clopidogrel idlulela kubisi lwebele. Ukuba kunjalo, kunokubangela iziphumo ezibi emntwaneni oncanciswa. Wena kunye nogqirha wakho unokufuna isigqibo sokuba uya kuthatha i-clopidogrel okanye uncelise.

Kubantwana: Ukhuseleko kunye nokusebenza kwe-clopidogrel khange kusekwe kubantwana abangaphantsi kweminyaka eyi-18.

Thatha njengoko kuyalelwe

Ithebhulethi yomlomo yeClopidogrel isetyenziselwa unyango lwexesha elide. Kuza nomngcipheko omkhulu ukuba awuyithathi njengoko kumiselwe.

Ukuba uyeka ukuthatha ichiza okanye ungayithathi kwaphela: Wonyusa umngcipheko wokuhlaselwa sisifo sentliziyo okanye ukubetha. Ezi meko zinokubulala.

Ukuba uyeke okwethutyana ukuthatha i-clopidogrel, qala ukuyithatha kwakhona kwakamsinya nje ukuba ugqirha akuxelele. Ukuyeka eli chiza kunokunyusa umngcipheko weemeko zentliziyo ebukhali, ukubetha, okanye igazi eliguqe imilenze okanye imiphunga.

Ukuba uphosa idosi okanye awuthathi ichiza kwishedyuli: Amayeza akho anokungasebenzi kakuhle okanye angayeka ukusebenza ngokupheleleyo. Ukuze eli chiza lisebenze kakuhle, isixa esithile kufuneka sibe semzimbeni wakho ngalo lonke ixesha.

Ukuba uthatha kakhulu: Unokuba namanqanaba ayingozi amachiza emzimbeni wakho. Iimpawu libanda, eli chiza ngaquka ukopha.

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Yintoni omele uyenze xa uphosa idosi: Ukuba uphosa idosi, thatha i-clopidogrel ngokukhawuleza ukuba ukhumbule. Ukuba phantse lixesha ledosi yakho elandelayo, tsiba idosi ephosiweyo. Thatha idosi enye kuphela ngexesha lakho eliqhelekileyo. Musa ukuthatha iidosi ezimbini ze-clopidogrel ngaxeshanye ngaphandle kokuba ugqirha wakho ukuxelele.

Ungaxela njani ukuba ichiza liyasebenza: Akufanele ube nesifo sentliziyo okanye ukubetha.

Ukuqwalaselwa okubalulekileyo kokuthatha i-clopidogrel

Gcina ezi ngqwalaselo engqondweni ukuba ugqirha wakho ukumisela ipilisi yeplopidogrel yomlomo kuwe.

Ngokubanzi

• Musa ukusika okanye ukutyumza ithebhulethi.

Ukugcina

• Gcina i-clopidogrel kubushushu begumbi kufutshane ne-77 ° F (25 ° C). Ingagcinwa ixesha elifutshane kubushushu obuphakathi kwe-59ºF kunye ne-86 ° F (15ºC kunye ne-30 ° C).
• Sukugcina eli yeza kwiindawo ezifumileyo okanye ezimanzi, ezinjengezindlu zangasese.

Ukuhamba

Xa uhamba namayeza akho:

• Soloko uphatha amayeza akho kunye nawe. Xa ubhabha, ungaze uyibeke kwingxowa ekhangelwe. Yigcine kwibhegi yakho yokuqhubela phambili.
• Musa ukuzikhathaza ngoomatshini beX-ray kwisikhululo seenqwelo-moya. Abayi konakalisa amayeza akho.
• Kusenokufuneka ubonise abasebenzi besikhululo seenqwelomoya ilebhile yekhemesti yakho. Soloko uphatha ikhonteyina eneleta emiselweyo yentsusa.
• Musa ukubeka eli yeza kwigumbi leglavu lemoto yakho okanye ulishiye emotweni. Qiniseka ukuthintela ukwenza oku xa imozulu ishushu kakhulu okanye ibanda kakhulu.

Ukuzilawula

Ugqirha wakho uya kukufundisa kunye namalungu osapho lwakho iimpawu zokuhlaselwa sisifo sentliziyo, ukubetha, okanye ukopha kwegazi emilenzeni okanye emiphungeni. Ukuba uneempawu zezi ngxaki, kuya kufuneka uye kwigumbi likaxakeka okanye ubize u-911 kwangoko.

Ukubeka iliso kwezonyango

Ngaphambi kokuba uqale unyango nge-clopidogrel, ugqirha wakho angenza uvavanyo lofuzo ukujonga uhlobo lwakho lwe-CYP2C19. Olu vavanyo lwemfuza luya kunceda ugqirha wakho athathe isigqibo sokuba ngaba kufuneka uthathe i-clopidogrel. Ezinye ii-genotypes zicothisa indlela i-clopidogrel eyaphuke ngayo. Ukuba unolu hlobo lwe-genotype, eli chiza alinakusebenzela.

Ukuqinisekisa ukuba iyeza lakho liyasebenza kwaye likhuselekile kuwe, ugqirha wakho uya kujonga oku kulandelayo:

• ubalo lwegazi olupheleleyo (CBC)
• iimpawu zokopha

Iindleko ezifihliweyo

Ukuba uphathwa ngenxa ye-acon coronary syndrome, kusenokufuneka uthathe i-clopidogrel ene-aspirin. Ugqirha wakho unokukuxelela ngakumbi.

Ukufumaneka

Uninzi lweekhemesti zigcina uhlobo oluqhelekileyo lweclopidogrel. Nangona kunjalo, ayizizo zonke izinto ezithengisa ikhemesti iPlavix, ifom yegama lomthi. Ukuba ugqirha wakho umisela iPlavix, xa ugcwalisa amayeza akho, qiniseka ukubiza phambili ukuze uqiniseke ukuba ikhemesti yakho iyayiphatha.

Ngaba zikhona ezinye iindlela?

Kukho ezinye iziyobisi ezikhoyo ukunyanga imeko yakho. Abanye banokukulungela ngcono kunabanye. Thetha nogqirha wakho ngezinye iindlela zamachiza ezinokusebenzela wena.

Iphepha elichazayo ukuba awusenanto oyifunayo: I-Healthline yenze yonke imizamo yokuqinisekisa ukuba lonke ulwazi luchanekile, lubanzi kwaye luhlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.