I-Chloroquine: yintoni, yintoni kunye neziphumo ebezingalindelekanga

Umxholo

• Kusetyenziswa kwanjani
• 1. Isifo seengcongconi
• 2. I-Lupus erythematosus kunye ne-rheumatoid arthritis
• 3. I-hepatic amebiasis
• Ngaba i-chloroquine iyacetyiswa ukuba inyangwe usulelo lwe-coronavirus?
• Ngubani ongafanele asebenzise
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-Chloroquine diphosphate sisiyobisi esiboniswe kunyango lwe-malaria esibangelwaIPlasmodium vivax, iPlasmodium malariae kwaye IPlasmodium ovale, isibindi i-amebiasis, i-rheumatoid arthritis, i-lupus kunye nezifo ezibangela uvakalelo lwamehlo ekukhanyeni.

Eli yeza inokuthengwa ezikhemesti, xa kunikwa amayeza.

Kusetyenziswa kwanjani

Umlinganiselo we-chloroquine uxhomekeke kwisifo esiza kunyangwa. Amacwecwe kufuneka athathwe emva kokutya, ukuthintela isicaphucaphu kunye nokugabha.

1. Isifo seengcongconi

Idosi ecetyiswayo yile:

• Abantwana abaneminyaka emi-4 ukuya kwe-8: ithebhulethi enye ngosuku, iintsuku ezi-3;
• Abantwana ukusuka kwiminyaka eli-9 ukuya kweli-11 ubudala: iipilisi ezimbini ngosuku, iintsuku ezi-3;
• Abantwana abaneminyaka eli-12 ukuya kweli-14 ubudala: iipilisi ezintathu ngosuku lokuqala, kunye neepilisi ezimbini ngosuku lwesibini nolwesithathu;
• Abantwana abangaphezu kweminyaka eli-15 ubudala kunye nabantu abadala abaneminyaka engama-79 ubudala: iipilisi ezi-4 ngosuku lokuqala, kunye neepilisi ezintathu ngosuku lwesibini nolwesithathu;

Unyango lwe-malaria olubangelwaP. vivax kwayeP. ovale I-chloroquine, kufuneka inxulunyaniswe neprimaquine, kangangeentsuku ezisi-7 kubantwana abaphakathi kweminyaka emi-4 ukuya kwesi-8 kunye neentsuku ezisi-7 kubantwana abangaphezulu kweminyaka eli-9 nangabantu abadala.

Akukho nani laneleyo lamacwecwe e-chloroquine kubantwana abanobunzima obungaphantsi kwe-15 kg, njengoko iingcebiso zonyango zibandakanya iipilisi zeqhezu.

2. I-Lupus erythematosus kunye ne-rheumatoid arthritis

Elona thamo liphezulu licetyiswayo kubantu abadala li-4 mg / kg ngosuku, kangangenyanga enye ukuya kwezintandathu, kuxhomekeke kwimpendulo yonyango.

3. I-hepatic amebiasis

Idosi ekucetyiswa ukuba yenziwe ngabantu abadala yi-600 mg ye-chloroquine ngosuku lokuqala nolwesibini, ilandelwe ngama-300 mg ngosuku kangangeeveki ezimbini ukuya kwezintathu.

Kubantwana, idosi ekhuthazwayo yi-10 mg / kg / ngosuku lwe-chloroquine, kangangeentsuku ezili-10 okanye ngokokubona kukagqirha.

Ngaba i-chloroquine iyacetyiswa ukuba inyangwe usulelo lwe-coronavirus?

I-Chloroquine ayikhuthazwa kunyango losulelo kunye ne-coronavirus entsha, njengoko kubonisiwe kwizilingo ezininzi zeklinikhi kwizigulana ezine-COVID-19 ukuba eli chiza landise ukuphindaphinda kweziphumo ebezingalindelekanga ezinzulu kunye nokufa, kwaye akubonisanga ziphumo ziluncedo. Ekusetyenzisweni kwayo, okukhokelele ekunqunyanyisweni kwezilingo zonyango ezazisenzeka kunye neyeza.

Nangona kunjalo, iziphumo zolu vavanyo ziyahlalutywa, ukuze kuqondwe indlela yokusebenza kunye nokuthembeka kwedatha.

Ngokuka-Anvisa, ukuthengwa kwe-chloroquine ekhemesti kusavumelekile, kodwa kuphela kubantu abanemigqaliselo yonyango ephantsi kolawulo olukhethekileyo, kwizalathiso ezikhankanywe apha ngasentla okanye ababesele bebonisa ichiza, phambi kobhubhane we-COVID-19.

Jonga iziphumo zophando olwenziwe nge-chloroquine ukunyanga i-COVID-19 kunye nezinye iziyobisi eziphandwayo.

Ngubani ongafanele asebenzise

Eli yeza akufuneki lisetyenziswe kubantu abaxhalabisayo nakwezinye izinto ezikhoyo kwifomula, abantu abanesathuthwane, i-myasthenia gravis, i-psoriasis okanye esinye isifo esinganyangekiyo.

Ukongeza, akufuneki isetyenziselwe ukunyanga isifo seengcongconi kubantu abane porphyria cutanea tarda kwaye kufuneka isetyenziswe ngononophelo kubantu abanesifo sesibindi kunye nasesiswini, ukuphazamiseka kwemithambo-luvo kunye nokuphazamiseka kwegazi.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo ebezingalindelekanga ezixhaphakileyo ezinokubakho ngokusetyenziswa kwe-chloroquine yintloko ebuhlungu, isicaphucaphu, ukugabha, urhudo, iintlungu esiswini, ukurhawuzelela, ukucaphuka kunye namabala abomvu ebomvu kulusu.

Ukongeza, ukudideka kwengqondo, ukuxhuzula, ukwehla koxinzelelo lwegazi, utshintsho kwi-electrocardiogram kunye nombono ophindaphindiweyo okanye ongacacanga nawo unokwenzeka.