Yenza uKinase

Umxholo

• Luyintoni uvavanyo lwe-creatine kinase (CK)?
• Isetyenziselwa ntoni?
• Kutheni ndifuna uvavanyo lweCK?
• Kwenzeka ntoni ngexesha lovavanyo lweCK?
• Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
• Ngaba bukhona ubungozi kuvavanyo?
• Zithetha ntoni iziphumo?
• Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweCK?
• Izalathiso

Luyintoni uvavanyo lwe-creatine kinase (CK)?

Olu vavanyo lilinganisa inani le-creatine kinase (CK) egazini. I-CK luhlobo lweprotein, eyaziwa njenge-enzyme. Ininzi ifumaneka kwiimisipha zakho zentliziyo kunye nentliziyo, kunye nexabiso elincinci kwingqondo. Izihlunu zamathambo zezihlunu eziqhotyoshelwe emathanjeni akho. Asebenza ngamathambo akho ukukunceda ukuba ushukume kwaye unike umzimba wakho amandla kunye nokomelela. Imisipha yentliziyo ipompa igazi ngaphakathi nangaphandle kwentliziyo.

Zintathu iintlobo ze-enzymes ze-CK:

• I-CK-MM, ifumaneka ikakhulu kwimisipha yamathambo
• I-CK-MB, ifunyenwe ikakhulu kwimisipha yentliziyo
• I-CK-BB, ifumaneka ikakhulu kwizicwili zobuchopho

Inani elincinci le-CK egazini liqhelekile. Amanani aphezulu anokuthetha ingxaki yezempilo. Kuxhomekeke kudidi kunye nenqanaba le-CK efunyenweyo, oko kunokuthetha ukuba unomonakalo okanye isifo semisipha yamathambo, intliziyo, okanye ingqondo.

Amanye amagama: CK, CK iyonke, creatine phosphokinase, CPK

Isetyenziselwa ntoni?

Uvavanyo lwe-CK luhlala lusetyenziselwa ukufumanisa kunye nokujonga ukwenzakala kwezihlunu kunye nezifo. Ezi zifo zibandakanya:

• Imisipha dystrophy, isifo esinqabileyo esifa njengelifa esibangela ubuthathaka, ukonakala, kunye nokuphulukana nomsebenzi wezihlunu zamathambo. Oku kwenzeka ikakhulu emadodeni.
• IRhabdomyolis, ukonakala ngokukhawuleza kwezihlunu zemisipha. Ingabangelwa kukulimala kakhulu, isifo semisipha, okanye esinye isifo.

Uvavanyo lunokusetyenziselwa ukunceda ekuchongeni isifo sentliziyo, nangona kungenjalo rhoqo. Uvavanyo lweCK lwalusoloko luvavanyo oluqhelekileyo lokuhlaselwa sisifo sentliziyo. Kodwa olunye uvavanyo, olubizwa ngokuba yi-troponin, lufunyenwe lungcono ekufumaneni umonakalo wentliziyo.

Kutheni ndifuna uvavanyo lweCK?

Unokufuna uvavanyo lweCK ukuba uneempawu zesifo semisipha. Oku kubandakanya:

• Intlungu yezihlunu kunye / okanye neekram
• Ubuthathaka bemisipha
• Iingxaki zokulinganisela
• Ubudenge okanye ukurhawuzelela

Unokulufuna olu vavanyo ukuba wenzakele umsipha okanye wabetha. Amanqanaba e-CK anokungaphakami kude kube ziintsuku ezimbini emva kokonzakala okuthile, kungafuneka kuvavanywe amaxesha ambalwa. Olu vavanyo lunokunceda ukubonisa ukuba unomonakalo entliziyweni yakho okanye kwezinye izihlunu.

Kwenzeka ntoni ngexesha lovavanyo lweCK?

Ingcali yokhathalelo lwempilo iyakuthatha isampulu yegazi kumthambo engalweni yakho, isebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.

Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Awudingi naluphi na ulungiselelo olukhethekileyo lovavanyo lweCK.

Ngaba bukhona ubungozi kuvavanyo?

Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.

Zithetha ntoni iziphumo?

Ukuba iziphumo zakho zibonisa ukuba ungaphezulu kwenqanaba eliqhelekileyo le-CK, oko kunokuthetha ukuba unokwenzakala okanye isifo semisipha, yentliziyo, okanye yengqondo. Ukufumana ulwazi oluthe kratya, umboneleli wakho unoku-odola uvavanyo ukujonga amanqanaba ee-enzymes ezithile ze-CK:

• Ukuba une-enzymes ze-CK-MM eziqhelekileyo kunokuthetha ukuba unokwenzakala kwemisipha okanye isifo, njenge-muscular dystrophy okanye i-rhabdomyolis.
• Ukuba une-enzymes ze-CK-MB eziqhelekileyo, kunokuthetha ukuba unesifo sentliziyo okanye unesifo sentliziyo okanye kutshanje.
• Ukuba unee-enzymes ze-CK-BB eziqhelekileyo kunokuthetha ukuba unokubethwa sistroke okanye ukwenzakala kwengqondo.

Ezinye iimeko ezinokubangela amanqanaba aphezulu e-CK aquka:

• Amahlwili egazi
• Usulelo
• Ukuphazamiseka kwehomoni, kubandakanya ukuphazamiseka kwendlala kunye namadlala eadrenal
• Utyando olude
• Amayeza athile
• Ukuzilolonga kakhulu

Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo.

Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweCK?

Olunye uvavanyo lwegazi, olunjengepaneli ye-electrolyte kunye novavanyo lomsebenzi wezintso, unoku-odolwa kunye novavanyo lweCK.

Izalathiso

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2. I-KidsHealth evela kwi-Nemours [kwi-Intanethi]. Isiseko seNemours; c1995-2019. Imisipha yakho; [icatshulwe ngo-2019 ngoJuni 19]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://kidshealth.org/en/kids/muscles.html
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5. UMbutho weMuscular Dystrophy [kwi-Intanethi]. IChicago: Umbutho weMuscular Dystrophy; c2019. Ichazwe ngokulula: Uvavanyo lweKreatine Kinase; 2000 Jan 31 [icatshulwe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://www.mda.org/quest/article/simply-stated-the-creatine-kinase-test
6. Intliziyo kaZwelonke, iMiphunga, kunye neZiko leGazi [kwi-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Uvavanyo lwegazi; [icatshulwe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.nhlbi.nih.gov/health-topics/blood-tests
7. IZiko leLizwe leZiphazamiso ze-Neurological and Stroke [i-Intanethi]. I-Bethesda (MD): Isebe lezeMpilo laseMelika kunye neeNkonzo zoLuntu; Imisipha Dystrophy: Ithemba ngophando; [ihlaziywe ngo-2019 ngoMeyi 7; ikhankanywe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Muscular-Dystrophy-Hope-Through-Research
8. Impilo ye-UF: iYunivesithi yaseFlorida yezeMpilo [i-Intanethi]. IGainesville (FL): yeYunivesithi yaseFlorida yezeMpilo; c2019. Yenza uvavanyo lwephosphokinase: Ubume; [ihlaziywe ngo-2019 Juni 12; ikhankanywe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://ufhealth.org/creatine-phosphokinase-test
9. IYunivesithi yaseRochester Medical Centre [i-Intanethi]. URochester (NY): KwiYunivesithi yaseRochester Medical Centre; c2019. Health Encyclopedia: Ukudala uKinase (Igazi); [icatshulwe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=creatine_kinase_blood
10. Ezempilo ze-UW [kwi-Intanethi]. Madison (WI): Izibhedlele zeYunivesithi yaseWisconsin kunye neGunya leKlinikhi; c2019. Ulwazi lwezeMpilo: I-Creatine Kinase: Uvavanyo ngokubanzi; [ihlaziywe ngo-2018 Juni 25; ikhankanywe ngo-2019 ngoJuni 12]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://www.uwhealth.org/health/topic/medicaltest/creatine-kinase/abq5121.html
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Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.