I-Enbrel vs.Humira yeRheumatoid Arthritis: Ukuthelekiswa kwecala ngecala

Umxholo

• Ushwankathelo
• Iziseko kwi-Enbrel naseHumira
• Iimpawu zeziyobisi ecaleni
• Ukugcinwa kweziyobisi
• Iindleko, ukufumaneka kunye neinshurensi
• Imiphumela
• Ukusebenzisana kweziyobisi
• Sebenzisa nezinye iimeko zonyango
• Thetha nogqirha wakho

Ushwankathelo

Ukuba une-rheumatoid arthritis (RA), nonke niqhelene nohlobo lwentlungu kunye nokuqina kwamalungu okunokwenza nokuba ukuphuma ebhedini kusasa kube ngumzabalazo.

I-Enbrel ne-Humira ngamachiza amabini anokunceda. Jonga ezinto zenziwa zezi ziyobisi kunye nendlela ezihlangana ngayo.

Iziseko kwi-Enbrel naseHumira

I-Enbrel kunye neHumira ngamayeza amiselweyo asetyenziselwa ukunyanga i-RA.

Omabini la machiza yi-tumor necrosis factor (TNF) alpha inhibitors. I-alfa ye-TNF yiprotein eyenziwe ngamajoni akho omzimba. Inegalelo ekuvukeleni kunye nomonakalo odibeneyo.

I-Enbrel ne-Humira vimba isenzo se-TNF alpha ekhokelela kumonakalo ovela kukudumba okungaqhelekanga.

Izikhokelo zangoku azicebisi i-TNF inhibitors njengonyango lokuqala lwe-RA. Endaweni yoko bacebisa unyango nge-DMARD (njenge-methotrexate).

Ngaphandle kweRA, bobabini u-Enbrel noHumira bayaphatha:

• i-juvenile idiopathic arthritis (JIA)
• i-psoriatic arthritis (PsA)
• i-ankylosing spondylitis
• I-plaque psoriasis

Ukongeza, u-Humira uyaphatha:

• Isifo sikaCrohn
• ulcerative colitis (UC)
• i-hidradenitis suppurativa, imeko yolusu
• uveitis, ukudumba kwiliso

Iimpawu zeziyobisi ecaleni

I-Enbrel ne-Humira basebenza ngendlela efanayo ukunyanga i-RA, kwaye uninzi lweempawu zabo ziyafana.

Izikhokelo azibonisi ukukhetha kwi-inhibitor enye ye-TNF ngaphezulu kwenye, ngenxa yokunqongophala kobungqina obukholisayo bokuba enye iyasebenza ngakumbi kunenye.

Abanye abantu bayazuza ngokutshintshela kwi-inhibitor eyahlukileyo ye-TNF ukuba eyokuqala ayisebenzi, kodwa uninzi logqirha lunokucebisa ngokutshintshela kwichiza elahlukileyo leRA endaweni yoko.

Olu luhlu lulandelayo lubonisa amanqaku ala machiza mabini:

Ungafumanisa ukuba i-Enbrel SureClick Autoinjector kunye neepeni zeHumira ezikhethiweyo zilula kwaye zilula kakhulu ukuzisebenzisa kuneesirinji ezikhethiweyo. Bafuna amanyathelo ambalwa.

Abantu baya kuthi babone izibonelelo zeli chiza emva kweedosi ezi-2 ukuya kwezi-3, kodwa uvavanyo oloneleyo lweziyobisi lumalunga neenyanga ezintathu ukubona isibonelelo salo esipheleleyo.

Indlela umntu ngamnye aphendula ngayo nakweliphi na ichiza iya kwahluka.

Ukugcinwa kweziyobisi

I-Enbrel ne-Humira zigcinwa ngendlela efanayo.

Zombini kufuneka zigcinwe kwikhathoni yoqobo ukukhusela ekukhanyeni okanye ekonakaleni komzimba. Ezinye iingcebiso zokugcina zibonwa ngezantsi:

• Gcina iyeza kwifriji kubushushu obuphakathi kwe-36 ° F kunye ne-46 ° F (2 ° C kunye ne-8 ° C).
• Ukuba uhamba, gcina iyeza kubushushu begumbi (68-77 ° F okanye 20-25 ° C) ukuya kwiintsuku ezili-14.
  • Khusela iziyobisi ekukhanyeni nasekufuma.
  • Emva kweentsuku ezili-14 kubushushu begumbi, lahla iyeza kude. Musa ukuyibuyisela kwifriji.
  • Musa ukuyiqandisa iyeza okanye ulisebenzise ukuba linomkhenkce laze lanyibilika.

Iindleko, ukufumaneka kunye neinshurensi

I-Enbrel kunye ne-Humira zifumaneka kuphela njengeziyobisi ezinamagama, hayi i-genics, kwaye zibiza ixabiso elifanayo.

Iwebhusayithi yeGoodRx inokukunika umbono othe ngqo malunga neendleko zabo zangoku, ezichanekileyo.

Uninzi lwababoneleli ngeinshurensi bafuna ugunyaziso lwangaphambili kugqirha wakho ngaphambi kokuba bakugubungele kwaye bahlawule naliphi na kula machiza. Jonga inkampani yakho yeinshurensi okanye ikhemesti ukuze ubone ukuba ufuna isigunyaziso sangaphambili se-Enbrel okanye iHumira.

Ikhemesti yakho inokukunceda ngamaphepha ukuba ugunyaziso luyafuneka.

Uninzi lweekhemesti zithwala zombini i-Enbrel kunye neHumira. Nangona kunjalo, licebo elilungileyo ukubiza ikhemesti yakho kwangaphambili ukuqinisekisa ukuba ichiza lakho likhona.

Ii-Biosimilars ziyafumaneka kuwo omabini amachiza. Nje ukuba zifumaneke, ii-biosimilars zinokufikeleleka ngakumbi kunegama lohlobo lwechiza.

I-biosimilar ye-Enbrel yi-Erelzi.

Ii-biosimilars ezimbini ze-Humira, i-Amjevita kunye ne-Cyltezo, zamkelwe yi-US Food and Drug Administration (FDA). Nangona kunjalo, okwangoku ayifumaneki ukuba ithengwe eMelika.

I-Amjevita yafumaneka eYurophu ngo-2018, kodwa akulindelwanga ukubetha iimarike zase-US kude kube ngowama-2023.

Imiphumela

U-Enbrel no-Humira bakwiklasi enye yeziyobisi. Ngenxa yoko, baneziphumo ebezingalindelekanga ezifanayo.

Ezinye zeempembelelo eziqhelekileyo ziquka:

• impendulo kwindawo yenaliti
• usulelo lwesono
• intloko ebuhlungu
• irhashalala

Iziphumo ezibi kakhulu zinokubandakanya:

• ukwanda komngcipheko womhlaza
• iingxaki zenkqubo yemithambo-luvo
• iingxaki zegazi
• ukusilela kwentliziyo okutsha okanye okuya kusiba mandundu
• i-psoriasis entsha okanye eyandayo
• negazi lakho
• iimpendulo ezenzekelayo
• izifo ezinzulu
• ukucinezela amajoni omzimba

Omnye wabantu abali-177 ufumene ukuba i-adalimumab, okanye i-Humira, abasebenzisi bebengaphezulu kwamaxesha amathathu okunika ingxelo yokutshiswa kwenaliti / yokufakwa endaweni kunye nokuhlaba emva kweenyanga ezintandathu zonyango.

Ukusebenzisana kweziyobisi

Soloko ugqirha wakho uyazi malunga nawo onke amayeza, iivithamini, okanye imifuno oyithathayo. Oku kunokunceda ugqirha wakho ukuthintele ukuhlangana kwamachiza okunokwenzeka, okunokutshintsha indlela elisebenza ngayo ichiza lakho.

Ukudibana kunokuba yingozi okanye kuthintele amachiza ekusebenzeni kakuhle.

I-Enbrel ne-Humira bayasebenzisana namanye amachiza afanayo. Sebenzisa i-Enbrel okanye i-Humira ngezi zitofu zilandelayo kunye neziyobisi kunyusa umngcipheko wosulelo:

• Amayeza okugonya aphilayo, anje ngala:
  • I-varicella kunye ne-varicella zoster (irhashalala)
  • iherpes zoster (shingles) izitofu
  • I-FluMist, isitshizi se-intranasal somkhuhlane
  • iyeza lokugonya imasisi, uqwilikana, nerubella (MMR)
  • iziyobisi ezisetyenziselwa ukucinezela amajoni akho omzimba njenge-anakinra (Kineret) okanye i-abatacept (i-Orencia)
• Amanye amachiza omhlaza, njenge-cyclophosphamide kunye ne-methotrexate
• Ezinye iziyobisi zeRA ezifana nesulfasalazine
• Amachiza athile aqhutywa yiprotein ebizwa ngokuba yi-cytochrome p450, kubandakanya:
  • iwarfarin (Coumadin)
  • I-cyclosporine (iNeoral, iSandimmune)
  • mzobozi

Sebenzisa nezinye iimeko zonyango

Ukuba usulelo lwe-hepatitis B yintsholongwane, ukuthatha i-Enbrel okanye i-Humira kunokuvula isifo sakho. Oko kuthetha ukuba ungaqala ukufumana iimpawu ze-hepatitis B, ezinje:

• ukudinwa
• ukungabikho komdla
• ubumthubi besikhumba sakho okanye ezimhlophe zamehlo akho
• iintlungu kwicala lasekunene lesisu sakho

Usulelo olusebenzayo lunokukhokelela ekusileleni kwesibindi nasekufeni. Ugqirha wakho uya kuvavanya igazi lakho ukuze aqiniseke ukuba awunayo i-hepatitis B ngaphambi kokuba ufumane naliphi na kula machiza.

Thetha nogqirha wakho

I-Enbrel ne-Humira ziziyobisi ezifanayo. Zisebenza ngokulinganayo ekupheliseni iimpawu zeRA.

Nangona kunjalo, kukho umahluko omncinci, eminye yayo inokwenza ukuba kube lula ngakumbi ukuba uyisebenzise.

Umzekelo, iHumira ingathathwa rhoqo ngeveki okanye ngeveki, ngelixa i-Enbrel inokuthathwa kuphela ngeveki.Unokufumanisa ukuba ukhetha ezinye izinto ezisebenzisa, ezinje ngeepeni okanye ii-autoinjectors. Olu khetho lunokumisela ukuba yeyiphi iyeza olikhethayo.

Ukwazi okungakumbi malunga nala mayeza mabini kunokukunceda uthethe nogqirha wakho ukuze ufumanise ukuba ngaba yenye yazo yeyakho na.