I-Erenumab: xa ibonakalisiwe kunye nendlela yokuyisebenzisa kwimigraine

Umxholo

• Isebenza njani i-erenumab
• Kusetyenziswa kwanjani
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ngubani ongafanele asebenzise

I-Erenumab yinto esebenzayo esebenzayo, eveliswe ngohlobo lwenaliti, eyenzelwe ukuthintela kunye nokunciphisa ubunzima beentlungu kwimigraine kubantu abane-4 okanye iziqendu ezingaphezulu ngenyanga. Eli chiza lelokuqala kunye ne-anti-monoclonal antibody eyilelwe ngokukodwa ukuthintela i-migraine kwaye ithengiswa phantsi kwegama elithi Pasurta.

I-Migraine ibonakaliswa yintloko ebukhali kunye ne-pulsating entloko enokuthi ichaphazele icala elinye, kwaye inokuthi ihambisane nezinye iimpawu ezinje ngokuba isicaphucaphu, ukugabha, isiyezi, ubuntununtunu ekukhanyeni, iintlungu ezisentanyeni kunye nobunzima bokugxila. Funda ngakumbi malunga neempawu ze-migraine.

I-Erenumab ivumela ukunciphisa isiqingatha senani leemigraines kunye nexesha leziqendu zentlungu, ngeedosi ze-70 mg kunye ne-140 mg.

Isebenza njani i-erenumab

I-Erenumab yi-anti-monoclonal antibody yomntu esebenza ngokuthintela i-peptide receptor enxulumene ne-calcitonin gene, eyinxalenye yemichiza ekhoyo kwingqondo kwaye ebandakanyeka ekusebenzeni kwe-migraine kunye nexesha leentlungu.

I-peptide enxulumene ne-calcitonin gene kukholelwa ukuba idlala indima ephambili kwi-pathophysiology ye-migraine, enekhonkco kunye nabamkeli bayo ababandakanyeka ekusasazeni iintlungu. Kubantu abane-migraine, amanqanaba ale peptide anyuka ekuqaleni kwesiqendu, abuyela esiqhelweni emva kokuthomalalisa iintlungu, ngonyango lweziyobisi ezisetyenziselwa ukunyanga i-migraine, okanye xa uhlaselo luphela.

Ke, i-erenumab ayinakunciphisa kuphela iziqephu ze-migraine, kodwa inokunciphisa nokuthathwa kwamayeza asetyenziswayo ngoku ukunyanga imigraines, eneziphumo ebezingalindelekanga ezininzi.

Kusetyenziswa kwanjani

I-Pasurta kufuneka itofwe phantsi kolusu kusetyenziswa isirinji okanye ipeni egcwaliswe kwangaphambili, enokulawulwa ngumntu emva kokufumana uqeqesho olwaneleyo.

Umthamo ocetyiswayo yi-70 mg qho kwiiveki ezi-4, kwisitofu esinye. Ngamanye amaxesha, kunokuba yimfuneko ukulawula idosi eyi-140 mg qho kwiiveki ezi-4.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo eziqhelekileyo ezinokuthi zenzeke ngexesha lonyango kunye ne-erenumab ziimpendulo kwindawo yokujova, ukuqhina, ukuxhamla kwemisipha kunye nokubetha.

Ngubani ongafanele asebenzise

I-Pasurta iyaphikiswa kubantu abane-hypersensitive kuwo nawaphi na amacandelo akhoyo kwifomula kwaye ayikhuthazwa kubafazi abakhulelweyo okanye abasetyhini abancancisayo.