Uvavanyo lwe-FAN: yintoni, yintoni eyenzelwe kunye neziphumo

Umxholo

• Yenzelwe ntoni
• Luqhutywa njani uviwo
• Loluphi ulungiselelo oluyimfuneko
• Zithetha ntoni iziphumo

Uvavanyo lwe-ANA luhlobo lovavanyo olusetyenziswa ngokubanzi ukunceda ekufumaneni isifo se-autoimmune, ngakumbi iSystemic Lupus Erythematosus (SLE). Ke, olu vavanyo lujolise ekuboneni ubukho be-autoantibodies egazini, ezizinto ezichasene nomzimba ezihlasela iiseli kunye nezicubu ngokwazo.

Olu vavanyo lusekwe kwipateni ye-fluorescence ye-antibodies, eyenza ukuba ikwazi ukujongwa phantsi kwemicroscope kwaye incedise ekuchongeni izifo ezahlukeneyo. Nangona kuqhelekile ukuba neziphumo eziphantsi kuvavanyo lwe-ANA, xa eli nani liphezulu kakhulu, oko kunokuthetha ukuba kukho isifo esizenzekelayo, ekufuneka sichongiwe kwaye sinyangwe ngokukhawuleza ukukhupha iimpawu.

Yenzelwe ntoni

Olu vavanyo lwe-FAN lunokunceda ukufumanisa izifo ezizimeleyo ezifana nezi:

• ILupus, Esi sisifo sokuzimela komzimba esibonakaliswa kukunyuka kwamaxabiso amalungu, ulusu, amehlo kunye nezintso, umzekelo;
• Irheumatoid Arthritis, apho kukho khona iintlungu, ukuba bomvu kunye nokudumba kwamalungu. Nantsi indlela yokuchonga isifo samathambo;
• Ulutsha lwe-idiopathic arthritis, apho kukho ukudumba kwelungu elinye okanye nangaphezulu ebantwaneni;
• Ngokuzimela hepatitis, apho ubukho be-autoantibodies bubangela ukudumba esibindini. Yazi iimpawu eziphambili ze-hepatitis ezenzekelayo;
• Iscleroderma, esisifo esizenzekelayo esibonakaliswa kukunyuka kwemveliso ye-collagen, ebangela ukuba ulusu kunye namalungu aqine;
• DermatomyositisEsi sisifo sokudumba esibonakaliswa bubuthathaka bemisipha kunye nezilonda zesikhumba. Funda ngakumbi malunga nedermatomyositis;
• Isifo sikaSjogren, ebonakaliswa kukudumba kwamadlala ahlukeneyo emzimbeni, okukhokelela kwamehlo owomileyo nasemlonyeni, umzekelo. Nantsi indlela yokuqonda iimpawu zeSjogren's Syndrome.

Ngokubanzi, ugqirha usenokukrokrela ezi zifo ukuba umntu uneempawu ezithatha ixesha elide ukuba zinyamalale, ezinje ngamabala abomvu emzimbeni, ukudumba, iintlungu ezingapheliyo kumalungu, ukudinwa kakhulu okanye umkhuhlane omncinci, umzekelo.

Luqhutywa njani uviwo

Olu vavanyo lulula kakhulu, lufuna kuphela isixa esincinci segazi ukuba sisuswe yingcali eqeqeshiweyo, ethunyelwe kwilebhu yovavanyo.

Ukuqokelelwa kwegazi kuhlala kwenziwa esibhedlele, kodwa kunokwenziwa nakwiiklinikhi ezizodwa, kokubini nakubantu abadala. Kwimeko yeentsana, ingqokelela ihlala isenziwa ngokuhlaba kancinci elunyaweni, ngaphandle kwesidingo sokusebenzisa inaliti.

Kwilabhoratri, uviwo lwenziwa ngokudibanisa idayi ye-fluorescent ephawulwe ngamachiza omzimba ukuba achongwe kwisampulu. Emva koko, igazi elinedayi enelebhile lifakwa kwisitya esiqulathe inkcubeko yeeseli zomntu ezaziwa ngokuba ziiseli ze-Hep-2, ezivumela ukubonwa ngokucacileyo kwezakhiwo ezahlukeneyo zeeseli kunye nezigaba zomjikelo weseli. Yiyo loo nto kunokwenzeka ukuba kwenziwe uxilongo, kuba yenziwe ngohlobo lwe-fluorescence olugcinwe ngemicroscope.

Loluphi ulungiselelo oluyimfuneko

Akukho hlobo lukhethekileyo lokulungiselela uviwo lwe-FAN, kuyacetyiswa kuphela ukwazisa ugqirha malunga nonyango olusetyenziswayo kunye neengxaki zempilo ezinokubakho.

Zithetha ntoni iziphumo

Kubantu abasempilweni, uvavanyo lwe-FAN luhlala lubi okanye lungasebenzi, ngamaxabiso anje nge-1/40, 1/80 okanye 1/160. Nangona kunjalo, oku akuthethi ukuba nanini na xa kukho into engalunganga, akukho sifo somzimba. Ke, nokuba ayilunganga, kwaye ngokweempawu ezibonisiweyo, ugqirha unokuyalela olunye uvavanyo ukuqinisekisa ukuba ayisosifo sokuzimela.

Xa iziphumo zilungile, okanye zisebenza kwakhona, zihlala zibonisa amaxabiso 1/320, 1/640 okanye 1/1280. Ukongeza, kukho ipateni yokujonga okuhle esekwe kubumenyemenye obonwa phantsi kwemicroscope, enceda ukwahlula ngcono uhlobo lwesifo kwaye sinokubandakanya:

• Inyukliya efanayo: ingabonisa ubukho be-lupus, i-rheumatoid arthritis okanye i-juvenile idiopathic arthritis, kuxhomekeke kwi-antibody echongiweyo. Ukuba ubukho be-anti-DNA, anti-chromatin kunye ne-anti-histone antibodies zichongiwe, oku kubonisa i-lupus;
• Inyukliya ichaze i-centromeric: ihlala ibonisa iscleroderma;
• Intlawulo yenyukliya ichotshiwe: ngesiqhelo ibonisa isifo sikaSjögren okanye i-lupus, kuxhomekeke kwi-antibody echongiweyo;
• Inyukliya inechaphaza elingqindilili: i-lupus, i-rheumatoid arthritis okanye i-systemic sclerosis ngokwe-antibodies ezichongiweyo;
• I-cytoplasmic elungileyo: inokuba yi-polymyositis okanye i-dermatomyositis;
• Inwebu yenyukliya eqhubekayo: inokubonisa i-autoimmune hepatitis okanye i-lupus;
• Inyukliya enamachaphaza: ihlala iluphawu lwesystemosis sclerosis.

Ezi ziphumo kufuneka zisoloko zitolikwa kwaye zivavanywe ngugqirha kwaye, phantse kuzo zonke iimeko, iimvavanyo ezingaphezulu ziyafuneka ngaphambi kokuqinisekisa isifo.