I-Naloxone ibusindisa njani ubomi kwiOpioid Overdose

Umxholo

• Inkcazo yevidiyo
• Umbhalo
• Ulwazi lwevidiyo

Inkcazo yevidiyo

0:18 Yintoni i-opioid?

0:41 Intshayelelo yeNaloxone

0:59 Iimpawu ze-opioid overdose

1:25 Inikwa njani naloxone?

1:50 Isebenza njani naloxone?

2:13 Uwuchaphazela njani umzimba opioids?

3: 04 Iimpawu zokurhoxa kwe-Opioid

3:18 Ukunyamezelana

3:32 Indlela i-opioid overdose engakhokelela ngayo ekufeni

I-4: I-39 ye-NIH HEAL Initiative kunye nophando lwe-NIDA

Umbhalo

I-Naloxone ibusindisa njani ubomi kwiOpioid Overdose

UNALOXONE USINDISA UBOMI.

Akukho xesha lokuhlala ungenzi nto. Ngakumbi nangakumbi abantu bayafa kukudlula ngokweqile kwizinto ezithandwa yi-heroin, i-fentanyl, kunye nonyango lweyeza elinjenge-oxycodone kunye ne-hydrocodone. Yonke le yimizekelo yeeopioid.

Iiopioids sisiyobisi esivela kwisityalo seopopi poppy okanye esenziwe kwilebhu. Banokunyanga iintlungu, ukukhohlela kunye norhudo. Kodwa iiopioids zinokuba likhoboka kwaye zibulale.

Inani lokusweleka kwe-opioid overdose lenyuke ngaphezulu kwe-400% ukusukela ekuqaleni kwenkulungwane, amashumi amawaka obomi ngoku alahlekile minyaka le.

Kodwa ukusweleka okuninzi kunokuthintelwa ngonyango olusindisa ubomi: naloxone.

Xa unikwe kwangoko, i-naloxone inokusebenza ngemizuzu ukubuyisa ukubanda ngaphezulu. INaloxone ikhuselekile, ineziphumo ebezingalindelekanga ezimbalwa, kwaye ezinye iindlela zinokulawulwa ngabahlobo kunye nosapho.

Isetyenziswa nini naloxone?

Ungasindisa ubomi. Okokuqala, qaphela iimpawu zokudlula ngaphezulu:

• Umzimba oqhwalelayo
• Pale, ubuso bekhamera
• Iinzipho okanye imilebe eblue
• Izandi zokugabha okanye ukugungxula
• Ukungakwazi ukuthetha okanye ukuvuswa
• Ukuphefumla kancinci okanye ukubetha kwentliziyo

Ukuba uzibona ezi mpawu, tsalela umnxeba kwi-911 kwangoko kwaye ujonge ukusetyenziswa kwe-naloxone ukuba ikhona.

Inikwa njani naloxone?

Amalungiselelo asekhaya aquka ukutshiza ngeempumlo umntu akunikwe umntu xa elele ngomqolo okanye isixhobo esizifaka iyeza ngokuzenzekelayo ethangeni. Ngamanye amaxesha kufuneka idosi enye.

Ukuphefumla komntu nako kufuna ukubekwa esweni. Ukuba umntu uyeka ukuphefumla, qaphela ukuphefumla okuphefumlayo kunye neCPR ukuba uqeqeshiwe de kufike abaphenduli bokuqala.

Isebenza njani naloxone?

I-Naloxone yi-opioid antagonist, oko kuthetha ukuba ibhloka ii-opioid receptors ekubeni zisebenze. Inomtsalane kakhulu kwii-receptors kangangokuba iyankqonkqoza ezinye ii-opioids. Xa ii-opioid zihleli kwii-receptors zazo, zitshintsha umsebenzi weseli.

Ii-opioid receptors zifumaneka kwiiseli zemithambo-luvo ejikeleze umzimba wonke:

• Engqondweni, iiopioids zivelisa iimvakalelo zokuthuthuzela kunye nokulala.
• Kwi-brainstem, ii-opioids ziyaphumla ekuphefumleni kwaye zinciphise ukukhwehlela.
• Kwintambo yomqolo kunye ne-peripheral nerves, ii-opioids zinciphisa imiqondiso yeentlungu.
• Kwiphepha lokugaya, ii-opioid ziyaqhinwa.

Ezi zenzo ze-opioid zinokuba luncedo! Umzimba ngokwenyani uvelisa ii-opioid zawo ezibizwa ngokuba yi "endorphins," enceda ukuzolisa umzimba ngamaxesha oxinzelelo. Ii-Endorphins zinceda ukuvelisa "imbaleki ephezulu" enceda iimbaleki zemarathon ukuba zingene kwimidyarho ekhathazayo.

Kodwa iziyobisi ze-opioid, ezinje ngamayeza amayeza eentlungu okanye i-heroin, ineempembelelo ze-opioid ezinamandla. Kwaye ziyingozi ngakumbi.

Ixesha elingaphezulu, ukusetyenziswa kwe-opioid rhoqo kwenza umzimba uxhomekeke kwiziyobisi. Xa ii-opioid zithathiwe, umzimba uphendula ngeempawu zokurhoxa ezinjengentloko, ukubaleka kwentliziyo, ukubila, ukugabha, urhudo kunye neenyikima. Kwabaninzi, iimpawu ziziva zinganyamezeleki.

Ixesha elingaphezulu, ii-opioid receptors nazo aziphenduli kwaye umzimba ukhula ukunyamezelana neziyobisi. Amachiza amaninzi ayadingeka ukuvelisa iziphumo ezifanayo ...

Ukugqithisa ngokweqile kuyingozi ngakumbi kwisiphumo sayo kwinkqubo yengqondo, ukuphefumla okuphumuzayo. Ukuphefumla kungathomalalisa kangangokuba kuyeke… kukhokelela ekufeni.

I-Naloxone inkqonkqoza ii-opioid kwii-receptors zazo zijikeleze umzimba. Kwi-brainstem, i-naloxone inokubuyisela idrive yokuphefumla. Gcina ubomi.

Kodwa nokuba i-naloxone iyaphumelela, ii-opioid zisajikeleza, ke kufuneka ukuba kufunwe unyango lweengcali ngokukhawuleza. INaloxone isebenza kangangemizuzu engama-30-90 ngaphambi kokuba ii-opioid zibuyele kwii-receptors zazo.

I-Naloxone inokukhuthaza ukurhoxa kuba kunkqonkqoza ii-opioids kwii-receptors zazo ngokukhawuleza. Kodwa ngapha koko i-naloxone ikhuselekile kwaye ayinakulindeleka ukuba ivelise iziphumo ebezingalindelekanga.

INaloxone isindisa ubomi. Ukusuka kwi-1996 ukuya kwi-2014, ubuncinci i-26,500 ye-opioid overdoses e-United States ibuyiswe ziiseli zisebenzisa i-naloxone.

Ngelixa i-naloxone lonyango olunokusindisa ubomi, kufuneka kwenziwe okungaphezulu ukusombulula ubhubhane we-opioid overdose.

Amaziko kaZwelonke wezeMpilo asungule i-HEAL Initiative kwi-2018, eyandisa uphando kumaziko amaninzi e-NIH kunye namaZiko ukukhawulezisa izisombululo zesayensi kwingxaki yesizwe ye-opioid. Uphando luyaqhubeka ukuphucula unyango lokusetyenziswa gwenxa kwe-opioid kunye nokulutha, kunye nokuphucula ulawulo lwentlungu. IZiko likaZwelonke lokuSetyenziswa gwenxa kweziyobisi, okanye i-NIDA, liziko eliphambili le-NIH lophando malunga nokusetyenziswa gwenxa kwe-opioid kunye nokulutha, kunye nenkxaso yayo yanceda ukuphuculwa kwe-naloxone nasal spray spray.

Ngolwazi oluthe kratya, jonga iwebhusayithi ye-NIDA kwi drugabuse.gov kwaye ukhangele "naloxone," okanye undwendwele nih.gov kwaye ukhangele "inyathelo lokuphilisa i-NIH." Ulwazi ngokubanzi lwe-opioid lunokufumaneka kwiMedlinePlus.gov.

Le vidiyo yaveliswa nguMedlinePlus, umthombo othembekileyo wolwazi lwezempilo oluvela kwiThala leLizwe lezeMpilo.

Ulwazi lwevidiyo

Ipapashwe ngoJanuwari 15, 2019

Jonga le vidiyo kuluhlu lokudlalwayo lweMedlinePlus kwiThala leLizwe laseMelika lezeMpilo kwiYouTube kwi: https://youtu.be/cssRZEI9ujY

OBONWAYO Usuku lukaJeff

INKCAZELO: UJosie Anderson

UMCULO: "Awunakuphumla", nguDimitris Mann; "Uvavanyo lokunyamezela", nguEric Chevalier; Isixhobo se “Anxiety”, nguJimmi Jan Joakim Hallstrom, uJohn Henry Andersson