Ngaba i-Ibuprofen ingazonyusa iimpawu ze-COVID-19?

Umxholo

• Kutheni le nto ibuprofen inokulusongela usulelo?
• Yintoni eyaziwayo
• Kufuneka wenze ntoni xa uneempawu

Ukusetyenziswa kweIbuprofen kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ngexesha losulelo nge-SARS-CoV-2 kuthathwa njengokukhuselekileyo, kuba bekungenakwenzeka ukuqinisekisa ubudlelwane phakathi kokusetyenziswa kweli chiza kunye nokuwohloka kweempawu zokuphefumla Ubhubhane we-COVID. 19.

Ukongeza, isifundo esenziwe kwa-Israyeli ^[1] izigulane ezibekwe esweni ezisebenzise ibuprofen kwiveki phambi kokuchongwa kwe-COVID-19 kwaye ngexesha lonyango lokufumana isiqabu seempawu kunye neparacetamol kwaye yafumanisa ukuba ukusetyenziswa kwe-ibuprofen akuhambelani nokuwohloka kwemeko yezonyango yezigulana.

Ke, akukho bungqina bokuba ukusetyenziswa kwe-ibuprofen kunokunyusa ukubola kunye nokufa kwe-COVID-19 kwaye, ke ngoko, ukusetyenziswa kweli yeza kubonisiwe ngabasemagunyeni kwezempilo, kwaye kufanele ukuba kusetyenziswe phantsi kwengcebiso yezonyango.

Kutheni le nto ibuprofen inokulusongela usulelo?

Uphando lupapashwe kwiphephancwadi Amayeza okuphefumla eLancet ^[2] ithi ibuprofen inokuzenza mandundu iimpawu zabantu abaneentsholongwane zokuphefumla kwintsholongwane ebukhali, njengoko eli chiza liza kukwazi ukwandisa ukubonakaliswa kwe-ACE, eyamkelayo kwiiseli zomntu kwaye ikwabopha kwi-coronavirus entsha. Le ngxelo ibisekwe kwinto yokuba abaguli abanesifo seswekile kunye noxinzelelo lwegazi banenani eliphezulu lokufumana i-ACE receptors, ibuprofen kunye nezinye ii-NSAIDs kwaye baphuhlise i-COVID-19 ebukhali.

Olunye uphononongo lwenziwe ngeempuku zeswekile^[3], ikhuthaze ukusetyenziswa kwe-ibuprofen iiveki ezisibhozo kwiidosi ezisezantsi kunokuba kucetyisiwe, okukhokelela ekwandeni kokubonisa kwe-enzyme eguqula i-angiotensin 2 (ACE2) kwinyama yentliziyo.

Leya enzyme, i-ACE2, ibonakala njengenye yeendawo zokungena kwiintsholongwane zosapho lwe-coronavirus kwiiseli, kwaye ngenxa yesi sizathu, ezinye izazinzulu zicinga ukuba kukho ukwanda kwintetho yale enzyme ebantwini, ngakumbi Umphunga, kunokwenzeka ukuba intsholongwane inokuphindaphindeka ngokukhawuleza, ibangele iimpawu ezibi kakhulu.

Yintoni eyaziwayo

Ngaphandle kwezifundo ezikhutshiweyo malunga nobudlelwane obubi phakathi kwe-ibuprofen kunye ne-COVID-19, uMbutho wezeMpilo weHlabathi kunye nabanye abasemagunyeni kwezempilo babonisa ukuba abukho ubungqina benzululwazi bokuba ukusetyenziswa kwe-ibuprofen ngekhe kukhuseleke, kuba iziphumo ezizisiweyo bezisekelezelwe ekucingeni kwaye akukho Izifundo zabantu zenziwe ngokwenene. Ukongeza, ezinye izifundo zibonise ukuba ^[4]:

• Akukho bungqina ngqo bokuba ibuprofen inokunxibelelana ne-SARS-CoV-2;
• Akukho bungqina bokuba ibuprofen inoxanduva lokunyusa ukubonakaliswa kwe-enzyme eguqula i-angiotensin;
• Olunye uphononongo lwe-in vitro lubonise ukuba ibuprofen "inokuphula" i-ACE receptor, yenze ukuba kube nzima ukuhlangana kweseli-intsholongwane yeseli kunye nokunciphisa umngcipheko wentsholongwane engena kwiseli ngale ndlela;
• Akukho bungqina bokuba ukusetyenziswa kwe-ibuprofen kunokunyusa okanye kwandise umngcipheko wosulelo.

Nangona kunjalo, ezinye izifundo zisafuneka ukuqinisekisa ukungabikho kobudlelwane phakathi kwe-SARS-CoV-2 kunye nokusetyenziswa kwe-ibuprofen okanye ezinye ii-NSAID kunye nokuqinisekisa ukusetyenziswa okukhuselekileyo kwala machiza.

Kufuneka wenze ntoni xa uneempawu

Kwimeko yeempawu ezibuthathaka ze-COVID-19, ezinje ngomkhuhlane, ukukhohlela kakhulu kunye nentloko, umzekelo, ukongeza ekuhlukanisweni, kuyacetyiswa ukuba ubonane nogqirha ukuze ukhokelo lunikwe malunga nonyango oluza kusetyenziswa ukukhulula uphawu, ukusetyenziswa kweparacetamol okanye ibuprofen kungabonakaliswa, ekufuneka kusetyenziswe ngokweengcebiso zonyango.

Nangona kunjalo, xa iimpawu ziba nzima kakhulu, kwaye kunokubakho ubunzima ekuphefumleni nasezintlungwini zesifuba, eyona nto intle kukuba umntu aye esibhedlele ukuze kuqinisekiswe ukuxilongwa kwe-COVID-19 kwaye kuqalwe unyango oluthile ngonyango injongo yokuthintela ezinye iingxaki kunye nokukhuthaza umgangatho wobomi bomntu. Qonda ukuba lwenziwa njani unyango lwe-COVID-19.