Uphando lwamva nje nge-Endometriosis: Into ekufuneka uyazi

Umxholo

• Ukugqibela kunyango lwe-endometriosis
• Amayeza amatsha omlomo
• Izinketho zokuhlinzwa kunye novavanyo oluzayo lweklinikhi
• Ukugqibela kokuchonga i-endometriosis
• Uphando olungakumbi nge-endometriosis
• Ukuhlengahlengisa iiseli
• Unyango lwe-Gene
• Ukuthatha

Ushwankathelo

I-Endometriosis ichaphazela abafazi abaqikelelweyo. Ukuba uhlala ne-endometriosis, ungathatha amanyathelo okulawula iimpawu zeso sifo. Okwangoku akukabikho nyango, kodwa oososayensi basebenza nzima befunda i-endometriosis kunye nendlela enokuthi inyangwe ngayo.

Kwiminyaka yakutshanje, umzimba okhulayo wophando ujonge izizathu ezinokubangela i-endometriosis, iindlela ezingezizo zokuhlasela ezisetyenziselwa ukuxilonga imeko, kunye nokukhetha unyango lwexesha elide. Funda ukuze ufunde malunga nenkqubela phambili yamva nje.

Ukugqibela kunyango lwe-endometriosis

Ulawulo lweentlungu yeyona njongo iphambili kunyango oluninzi lwe-endometriosis. Omabini amayeza amayeza kunye neyeza zokunyanga iintlungu kunye nonyango lwehomoni zihlala zicetyiswa. Utyando lukhetho lonyango.

Amayeza amatsha omlomo

Ehlotyeni le-2018, i-US Food and Drug Administration (i-FDA) yavuma i-gonadotropin yokuqala yokukhupha i-hormone (GnRH) yokuchasana nabasetyhini ukunceda abasetyhini abaneentlungu eziphakathi ukuya kwi-endometriosis.

I-Elagolix yi. Isebenza ngokumisa imveliso ye-estrogen. IHormone estrogen inegalelo ekukhuleni kwe-endometrial scarring kunye neempawu ezingathandekiyo.

Kubalulekile ukuba uqaphele ukuba abachasi be-GnRH ngokuyimfuneko bafaka umzimba ekuyekeni ukuya exesheni. Oko kuthetha ukuba iziphumo ebezingalindelekanga zinokubandakanya ukuphulukana nethambo, ukutsha, okanye ukoma kwilungu lobufazi, phakathi kwabanye.

Izinketho zokuhlinzwa kunye novavanyo oluzayo lweklinikhi

I-Endometriosis Foundation yaseMelika ithathela ingqalelo utyando lwe-laparoscopic excision njengolumgangatho wegolide kunyango lwezi meko. Injongo yoqhaqho kukususa izilonda ze-endometrium ngelixa kugcinwa izicwili ezisempilweni.

Utyando lunokuphumelela ekunciphiseni iintlungu ezinxulumene ne-endometriosis, kuphawula ukuphononongwa kwijenali yezeMpilo yabasetyhini. Kuyenzeka nokuba, ngemvume engaphambi kolwazi, kugqirha enze utyando lokunyanga ukunyanga i-endometriosis njengenxalenye yenkqubo efanayo yokufumanisa imeko. Uphononongo lwango-2018 olubandakanya ngaphezulu kwama-4,000 abathathi-nxaxheba lwafumanisa ukuba utyando lwe-laparoscopic excision lwalusebenza nasekunyangeni iintlungu ze-pelvic kunye neempawu ezinxulumene namathumbu e-endometriosis.

Uvavanyo olutsha lweklinikhi eNetherlands lujolise ekwenzeni utyando lusebenze ngakumbi. Umcimbi omnye ngeendlela zangoku zotyando kukuba ukuba izilonda ze-endometriosis azisuswanga ngokupheleleyo, iimpawu zingabuya. Xa oku kusenzeka, utyando lusenokufuna ukuphindwa. Uvavanyo olutsha lweklinikhi luvavanya ukusetyenziswa kwe-imaging ye-fluorescence ukunceda ukuthintela isidingo sotyando oluphindaphindiweyo.

Ukugqibela kokuchonga i-endometriosis

Ukusuka kwiimviwo zepelvic ukuya kwii-ultrasound ukuya kutyando lwe-laparoscopic, ezona ndlela zisebenzayo zokuchonga i-endometriosis zichaphazeleka ngokufanelekileyo. Oogqirha abaninzi banokuchonga i-endometriosis esekwe kwimbali yezonyango kunye novavanyo lomzimba. Nangona kunjalo, utyando lwe-laparoscopic- olubandakanya ukufaka ikhamera encinci ukuvavanya ukonzakala kwe-endometrial-iseyindlela ekhethiweyo yokufumanisa isifo.

I-Endometriosis inokuthatha phakathi kweminyaka esi-7 ukuya kweli-10 yokufumanisa isifo. Ukunqongophala kovavanyo lokuchonga olungangenisiyo sesinye sezizathu zelo xesha lide.

Ingatshintsha ngenye imini. Kutshanje, izazinzulu ngeFeinstein Institute of Medical Research zipapashe uphononongo olucebisa ukuba kuvavanywa iisampulu zegazi zokuya exesheni kunokubonelela ngendlela esebenzayo, engeyiyo yokuhlasela yokufumanisa i-endometriosis.

Abaphandi bafumanise ukuba iiseli ezisegazini lokuya exesheni kwabasetyhini abane-endometriosis baneempawu ezithile. Ngokukodwa, igazi lokuya exesheni liqulethe iiseli ezimbalwa zokubulala zesibeleko. Ikwanomdla wokuba neeseli ezinokukhubazeka "kokumiselwa ngokusemthethweni," inkqubo elungiselela isibeleko sokukhulelwa.

Uphando olungakumbi luyafuneka. Kodwa kunokwenzeka ukuba aba bamakishi ngenye imini banokunika indlela ekhawulezayo nengangenisi ngeniso yokuchonga i-endometriosis.

Uphando olungakumbi nge-endometriosis

Uphando malunga nokuchongwa kwe-endometriosis kunye nonyango luyaqhubeka. Izifundo ezibini eziphambili- kunye nezifundo ze-sci-fi zavela ekupheleni kwe-2018:

Ukuhlengahlengisa iiseli

Kwisifundo esivela kwiNyango yaseNyakatho-ntshona, abaphandi bafumanise ukuba iiseli zomntu ezinamandla amakhulu (iPS) zinokuthi "zenziwe ngokutsha" ukuze ziguqulwe zibe ziiseli zesibeleko ezinempilo. Oku kuthetha ukuba iiseli zesibeleko ezibangela iintlungu okanye ukudumba zinokutshintsha endaweni yeeseli ezisempilweni.

Ezi seli zenziwe ngokubonelelwa kwabasetyhini iiseli ze-iPS. Oko kuthetha ukuba akukho bungozi bokwaliwa kwamalungu, njengoko kukho nezinye iintlobo zokufakelwa.

Uphando olungakumbi luyafuneka. Kodwa kukho ukubakho kwonyango olusekwe kwiseli kwisisombululo sexesha elide kwi-endometriosis.

Unyango lwe-Gene

Isizathu se-endometriosis asikaziwa. Olunye uphando lubonisa ukuba ukucinezelwa kwemfuza ethile kungadlala indima.

Oososayensi kwiYunivesithi yaseYale bapapasha isifundo befumanisa ukuba i-MicroRNA Let-7b-eyandulelayo yemfuza elawula amabinzana-icinezelwe kubafazi abane-endometriosis. Isisombululo? Ukulawula i-Let-7b kwabasetyhini kunokunceda ukunyanga imeko.

Ukuza kuthi ga ngoku, unyango lubonakalisiwe lusebenza kwiimpuku. Abaphandi babone ukuncipha okukhulu kwizilonda ze-endometrium emva kokufaka iigundane nge-Let-7b. Olunye uphando luyafuneka ngaphambi kovavanyo ebantwini.

Ukuba unyango lwemfuza luyasebenza ebantwini, kunokuba yindlela enganyangiyo, engafunekiyo, kunye nengeyoyehomoni kunyango lwe-endometriosis.

Ukuthatha

Ngelixa lungekho unyango lwe-endometriosis, iyanyangeka. Uphando ngemeko, ukhetho kunyango, kunye nolawulo luyaqhubeka. Ukuba unomdla wokufunda ngakumbi, thetha nogqirha wakho. Bangayiphendula imibuzo yakho kwaye bacebise ngezixhobo zokufumana ngakumbi.