Ulawulo lweCholesterol: PCSK9 Inhibitors vs.

Umxholo

• Malunga nemimiselo
• Indlela abasebenza ngayo
• Iindidi
• Malunga ne-PCSK9 inhibitors
• Xa zichaziwe
• Indlela abasebenza ngayo
• Imiphumela
• Ukusebenza ngempumelelo
• Iindleko
• Thetha nogqirha wakho
• Thetha nogqirha wakho

Intshayelelo

Phantse izigidi ezingama-74 zabantu baseMelika bane-cholesterol ephezulu, ngokwe. Nangona kunjalo, bangaphantsi kwesiqingatha abafumana unyango ngayo. Oku kubabeka emngciphekweni omkhulu wokuhlaselwa sisifo sentliziyo kunye nokufa icala. Ngelixa umthambo kunye nokutya okusempilweni kunokuhlala kunceda ukulawula amanqanaba e-cholesterol, ngamanye amaxesha amayeza ayimfuneko.

Iindidi ezimbini zamayeza amiselweyo ukunyanga i-cholesterol ephezulu kubandakanya ii-statins kunye ne-PCSK9 inhibitors. IiStatins lunyango oludumileyo olufumanekayo ukusukela nge1980s. I-PCSK9 inhibitors, kwelinye icala, luhlobo olutsha lwechiza le-cholesterol. Baye bavunywa nguLawulo loKutya noLawulo lweziyobisi ngo-2015.

Xa wena nogqirha wakho nithatha isigqibo ngeyeza le-cholesterol, unokuqwalasela izinto ezinjengeempembelelo, iindleko kunye nokusebenza. Funda ukuze ufunde ngakumbi ngala machiza kunye nendlela ezi ntlobo zimbini zithelekisa ngayo.

Malunga nemimiselo

I-Statins yenye yeendlela eziqhelekileyo zamayeza asetyenziselwa ukunceda ukunciphisa i-cholesterol. Ukuba une-cholesterol ephezulu okanye enye ingozi yomzimba, ugqirha wakho unokucebisa ukuba uqale ukuthatha istin. Zihlala zisetyenziswa njengonyango lodidi lokuqala lwe-cholesterol ephezulu. Oku kuthetha ukuba lunyango lokuqala olunokucetyiswa ngugqirha wakho.

Indlela abasebenza ngayo

IiStatins zisebenza ngokuthintela into ebizwa ngokuba yi-HMG-CoA ukunciphisa. Eli likhompawundi kufuneka isibindi sakho senze i-cholesterol. Ukuthintela le nto kunciphisa isixa secholesterol esenziwe sisibindi sakho. Iitatins ziyasebenza ngokunceda umzimba wakho uphinde ubambe nayiphi na i-cholesterol eqokeleleneyo ezindongeni zemithambo yegazi lakho. Ukuze ufunde okungakumbi, funda malunga nendlela esebenza ngayo.

Iindidi

Ii-Statins ziza ngohlobo lweecwecwe okanye iicapsule ozithatha ngomlomo. Zininzi iintlobo zee-statins ezikhoyo e-United States namhlanje. Ziquka:

• atorvastatin (Lipitor)
• ifluvastatin (Lescol)
• I-lovastatin (Altoprev)
• ipravastatin (Pravachol)
• Irosuvastatin (Crestor)
• Simvastatin (iZocor)
• ipitavastatin (Livalo)

Malunga ne-PCSK9 inhibitors

Iitatins zinokumiselwa kubantu abaninzi abane-cholesterol ephezulu, kodwa ii-PCSK9 inhibitors zihlala zimiselwe kuphela iintlobo ezithile zabantu. Ngenxa yokuba ii-statins bezijikeleze ixesha elide, siyazi ngakumbi ukuba zisebenza njani. Ii-PCSK9 inhibitors zintsha kwaye ke zinedatha yokhuseleko lwexesha elide.

Kwakhona, ii-PCSK9 inhibitors zibiza kakhulu xa kuthelekiswa ne-statins.

Ii-PCSK9 inhibitors zinikwa ngenaliti kuphela. Zimbini kuphela ii-PCSK9 Inhibitors ezikhoyo namhlanje e-United States: Ixabiso (alirocumab) kunye ne-Repatha (evolocumab).

Xa zichaziwe

Ikholeji yaseMelika yeCardiology icebisa ukuba wena nogqirha wakho nithathele ingqalelo i-PCSK9 inhibitor kuphela ukuba:

• uthathwa njengomngcipheko omkhulu wengxaki yentliziyo kwaye i-cholesterol yakho ayilawulwa yimimiselo okanye ezinye iziyobisi ezinciphisa i-cholesterol
• Unemeko yemfuza ebizwa ngokuba yi-hypercholesterolemia yosapho, ebandakanya amanqanaba aphezulu kakhulu e-cholesterol

Kuzo zombini ezi meko, ii-PCSK9 inhibitors zihlala zichaziwe emva kweentlobo ezimbini zamayeza ezingakhange zincede ukuthoba amanqanaba akho e-cholesterol. Ngokomzekelo, ugqirha wakho unokumisela kuqala i-statin.Ukuba oko akwehlisi amanqanaba akho e-cholesterol ngokwaneleyo, ugqirha wakho unokucebisa i-ezetimibe (iZetia) okanye iziyobisi ezibizwa ngokuba zii-resins ze-bile acid. Imizekelo yoku ibandakanya icholestyramine (iLocholest), i-colesevelam (i-Welchol), okanye i-colestipol (i-Colestid).

Ukuba amanqanaba akho e-cholesterol asephezulu kakhulu emva kolu hlobo lwesibini lonyango, ugqirha wakho unokucebisa nge-PCSK9 inhibitor.

Indlela abasebenza ngayo

Ii-PCSK9 inhibitors zinokusetyenziswa ukongeza okanye endaweni yeestemins. La machiza asebenza ngokwahlukileyo. I-PCSK9 inhibitors ijolise kwiproteni esibindini ebizwa ngokuba yiproprotein convertase subtilisin kexin 9, okanye iPCSK9. Ngokunciphisa inani le-PCSK9 emzimbeni wakho, ii-PCSK9 inhibitors zivumela umzimba wakho ukuba ususe i-cholesterol ngokufanelekileyo.

Imiphumela

I-Statins kunye ne-PCSK9 inhibitors nganye inokubangela iziphumo ebezingalindelekanga ezinobuzaza kunye nezibi, kwaye iziphumo zahlukile phakathi kwamachiza.

Ukusebenza ngempumelelo

Iingxelo zibonisiwe ukunciphisa i-cholesterol kubantu abaninzi. Zisetyenzisiwe ukusukela nge1980s kunye neziphumo zazo ziye zafundwa kumawakawaka abantu abathatha ii-statins ukunqanda ukubetha kwentliziyo kunye nokubetha.

Ngokwahlukileyo, ii-PCSK9 inhibitors zisandula ukwamkelwa, ke idatha yokhuseleko yexesha elide ayilunganga. Nangona kunjalo ii-PCSK9 inhibitors zisebenza kakhulu kwabanye abantu.Olunye uphononongo lubonise ukuba i-alirocumab yehlise amanqanaba e-cholesterol ngama-61 epesenti. Ikwanciphisile ukubakho kweziganeko zentliziyo ezinje ngokuhlaselwa kwentliziyo kunye nokubetha. Olunye uphando lufumene iziphumo ezifanayo nge-evolocumab.

Iindleko

Iingxelo ziyafumaneka ngegama-lophawu kunye neefom zohlobo oluqhelekileyo. Iijenerikhi ngokubanzi zibiza ixabiso elingaphantsi kweenguqulelo zebrendi, ke ii-statins zinokungabizi kakhulu.

Ii-PCSK9 inhibitors zintsha, ngenxa yoko azinazo iinguqulelo ezikhoyo ngoku. Ngesi sizathu, zibiza kakhulu kunee-statins. Iindleko ze-PCSK9 inhibitors zingaphezulu kwe- $ 14,000 ngonyaka. Ukongeza, ukuba le ndleko igutyungelwe yi-inshurensi yakho, kuya kufuneka uwele kwelinye lala macandelo mabini acetyiswayo ngokusebenzisa i-PCSK9 inhibitors. Ukuba awulungelanga kolunye lwezo ndidi, kuya kufuneka uhlawule i-PCSK9 inhibitor ngokwakho.

Thetha nogqirha wakho

I-Statins kunye ne-PCSK9 inhibitors zibalulekile ekukhetheni iziyobisi kunyango lwe-cholesterol ephezulu. Ngelixa zombini iintlobo zamachiza zinceda ukunciphisa amanqanaba e-cholesterol, kukho umahluko ophambili. Itheyibhile engezantsi ichaza lo mahluko ngokujonga nje.

Thetha nogqirha wakho

Ukuba une-cholesterol ephezulu kwaye ucinga ukuba olunye lwezi ndidi zamachiza lunokulunga kuwe, inyathelo lakho lokuqala kukuthetha nogqirha wakho. Banokukuxelela ngakumbi ngala machiza kunye nezinye iindlela zokhetho. Eminye imibuzo onokuxoxa ngayo nogqirha wakho inokuba:

• Ngaba amayeza linyathelo elilandelayo kum ekulawuleni i-cholesterol yam ephezulu?
• Ngaba ndiyazifezekisa iikhrayitheriya ezimbini zabantu abanokumiselwa nge-PCSK9 inhibitors?
• Ngaba ndifanele ndithethe neengcali ze-lipid?
• Ngaba kufuneka ndiqale isicwangciso sokuzivocavoca ukunceda ukulawula i-cholesterol yam?
• Ungandithumela kwidayiti ebhalisiweyo yokundinceda ukuba ndilawule indlela enditya ngayo?