I-Phenylalanine: Izibonelelo, Iziphumo ebezingalindelekanga kunye neMithombo yokutya

Umxholo

• Yintoni iPhenylalanine?
• Kubalulekile ukuba usebenze ngokuSebenzayo komzimba wakho
• Ngaba kunokuba luncedo kwiimeko ezithile zonyango
• Imiphumela
• Ukutya okuphezulu ePhenylalanine
• Umgca osezantsi

I-Phenylalanine yi-amino acid efumaneka kukutya okuninzi kwaye isetyenziswe ngumzimba wakho ukuvelisa iiproteni kunye nezinye iimolekyuli ezibalulekileyo.

Ifundwe ngeziphumo zayo kuxinzelelo, iintlungu kunye nokuphazamiseka kolusu.

Eli nqaku likuxelela yonke into ofuna ukuyifumana malunga ne-phenylalanine, kubandakanya izibonelelo zayo, iziphumo ebezingalindelekanga kunye nemithombo yokutya.

Yintoni iPhenylalanine?

I-Phenylalanine yi-amino acid, ezizibhloko zokwakha zeeproteni emzimbeni wakho.

Le molekyuli ikho ngeendlela ezimbini okanye kumalungiselelo: L-phenylalanine kunye no-D-phenylalanine. Ziphantse zafana kodwa zinendlela eyahlukileyo yolwakhiwo lweemolekyuli ().

Ifom ye-L ifumaneka ekutyeni kwaye isetyenziselwa ukuvelisa iiproteni emzimbeni wakho, ngelixa ifom ye-D inokwenziwa ukuba isetyenziswe kwizicelo ezithile zonyango (2, 3).

Umzimba wakho awukwazi ukuvelisa ngokwaneleyo i-L-phenylalanine ngokwawo, ke ithathwa njengeyona amino acid ibalulekileyo ekufuneka ifunyenwe kukutya kwakho (4).

Kufunyenwe kwiintlobo ezahlukeneyo zokutya - zombini izityalo kunye nemithombo yezilwanyana ().

Ukongeza kwindima yayo kwimveliso yeeproteni, i-phenylalanine isetyenziselwa ukwenza ezinye iimolekyuli ezibalulekileyo emzimbeni wakho, uninzi lwazo oluthumela imiqondiso phakathi kwamalungu ahlukeneyo omzimba wakho ().

I-Phenylalanine ifundwe njengonyango lweemeko ezininzi zonyango, kubandakanya ukuphazamiseka kolusu, uxinzelelo kunye nentlungu (3).

Nangona kunjalo, kunokuba yingozi kubantu abane-disney disorder phenylketonuria (PKU) (7).

I-Phenylalanine yi-amino acid ebalulekileyo esetyenziselwa ukuvelisa iiproteni kunye nokusayina iimolekyuli. Kufundwe njengonyango lweemeko ezininzi zonyango kodwa kuyingozi kwabo banesifo esithile semfuza.

Kubalulekile ukuba usebenze ngokuSebenzayo komzimba wakho

Umzimba wakho udinga i-phenylalanine kunye nezinye ii-amino acid ukwenza iiproteni.

Iiproteni ezininzi ezibalulekileyo zifumaneka kwingqondo yakho, igazi, izihlunu, amalungu angaphakathi kwaye phantse kuyo yonke indawo emzimbeni wakho.

Ngaphezu koko, i-phenylalanine ibalulekile kwimveliso yezinye iimolekyuli, kubandakanya (3):

• Ityrosine: Le amino acid iveliswa ngokuthe ngqo kwi-phenylalanine. Ingasetyenziselwa ukwenza iiproteni ezintsha okanye ziguqulwe zibe zezinye iimolekyuli kolu luhlu (,).
• Epinephrine kunye norepinephrine: Xa udibana noxinzelelo, ezi molekyuli zibalulekile ekuphenduleni komzimba wakho "ukulwa okanye ukubhabha" ().
• IDopamine: Le molekyuli iyabandakanyeka kwiimvakalelo zolonwabo kwingqondo yakho, kunye nokwenza iinkumbulo kunye nezakhono zokufunda ().

Iingxaki ngemisebenzi eqhelekileyo yezi molekyuli inokubangela iziphumo ezibi zempilo (,).

Kuba i-phenylalanine isetyenziselwa ukwenza ezi molekyuli emzimbeni wakho, ifundwe njengonyango olunokubakho lweemeko ezithile, kubandakanya ukudakumba ().

I-Phenylalanine inokuguqulwa iye kwi-amino acid tyrosine, ethi isetyenziselwe ukuvelisa iimolekyuli ezibalulekileyo zokubonisa. Ezi molekyuli zibandakanyeka kwimiba yokusebenza komzimba wakho okuqhelekileyo, kubandakanya imeko yakho kunye neempendulo zoxinzelelo.

Ngaba kunokuba luncedo kwiimeko ezithile zonyango

Izifundo ezininzi ziye zavavanya ukuba ngaba i-phenylalanine inokuba luncedo na kunyango lweemeko ezithile zonyango.

Olunye uphando lubonakalisile ukuba lunokusebenza kunyango lwe-vitiligo, isifo solusu esibangela ukulahleka kwebala lolusu kunye neblotching ().

Olunye uphononongo luxele ukuba ukongeza i-phenylalanine supplements kwi-ultraviolet (UV) ukukhanya kokukhanya kunokuphucula ulusu lolusu kubantu abakule meko (,).

I-Phenylalanine inokusetyenziselwa ukuvelisa imolekyuli dopamine. Ukungasebenzi kakuhle kwe-Dopamine kwingqondo kunxulunyaniswa nezinye iindlela zoxinzelelo (,).

Isifundo esinye esincinci se-12-sabonisa isibonelelo esinokubakho somxube we-D- kunye ne-L-iifom zale asidi ye-amino ukunyanga uxinzelelo, nge-2/3 yezigulana ezibonisa ukuphucuka ().

Nangona kunjalo, kukho enye inkxaso encinci kwimiphumo ye-phenylalanine ekudakaleni, kwaye ezininzi izifundo azifumananga izibonelelo ezicacileyo (,,).

Ukongeza kwi-vitiligo kunye noxinzelelo, i-phenylalanine ifundelwe iziphumo ezinokubakho:

• Intlungu: Uhlobo lwe-D lwe-phenylalanine lunokuba negalelo ekuphumleni kwentlungu kwezinye iimeko, nangona iziphumo zophando zixubekile (2,,,).
• Ukurhoxiswa kotywala: Inani elincinci lophando libonisa ukuba le amino acid, kunye nezinye iiamino acid, inokunceda ukunciphisa iimpawu zokurhoxa etywaleni ().
• Isifo sikaParkinson: Ubungqina obunqunyelweyo bucebisa ukuba i-phenylalanine inokuba luncedo ekunyangeni isifo sika-Parkinson, kodwa kufuneka izifundo ezingaphezulu ().
• I-ADHD: Okwangoku, uphando alubonisi zibonelelo zale asidi ye-amino kunyango lwengxaki yokuphazamiseka kwengqondo (ADHD) (,).

I-Phenylalanine inokuba luncedo ekunyangeni isifo se-vitiligo. Ubungqina abuboneleli ngenkxaso eyomeleleyo yokusebenza kwale amino acid ekunyangeni ezinye iimeko, nangona kwenziwe uphando olunomgangatho ophezulu.

Imiphumela

I-Phenylalanine ifunyenwe kukutya okuneprotheyini kwaye "yaziwa ngokubanzi njengekhuselekileyo" kuLawulo lokuTya kunye noLawulo lweziyobisi (FDA) (27).

Isixa sale amino acid sifumaneka kukutya akufuneki sibeke umngcipheko kubantu abasempilweni.

Ngaphezulu, zimbalwa okanye azikho iziphumo ebezingalindelekanga ezijongwa ngokubanzi kumthamo wokuncedisa we-23-45 mg ngeponti nganye (50-100 mg ngekg) yobunzima bomzimba (,).

Nangona kunjalo, kunokuba ngcono kubafazi abakhulelweyo ukunqanda ukuthatha izongezo ze-phenylalanine.

Ukongeza, kukho umahluko ophawuleka kakhulu kukhuseleko oluqhelekileyo lwe-amino acid.

Abantu abane-amino acid metabolism disorder phenylketonuria (PKU) abakwazi ukuqhuba ngokufanelekileyo i-phenylalanine. Banokuba noxinzelelo lwe-phenylalanine egazini labo malunga namaxesha angama-400 aphezulu kunalawo angenayo iPKU (3, 7).

Oku kugxila kuyingozi kunokubangela ukonakala kwengqondo kunye nokukhubazeka kwengqondo, kunye neengxaki zothutho lwee-amino acid kwingqondo (7,).

Ngenxa yobuzaza bolu ngxaki, abantwana ngokubanzi bahlolwe iPKU kwakamsinya emva kokuzalwa.

Abantu abane-PKU babekwa kwizidlo ezikhethekileyo ezineprotein, egcinwa ngokubanzi ebomini (7).

I-Phenylalanine ithathwa njengekhuselekile kumanani afumaneka kukutya okuqhelekileyo. Nangona kunjalo, abantu abanesifo se-phenylketonuria (PKU) abanako ukuhambisa le amino acid kwaye kufuneka banciphise ukusetyenziswa ngenxa yeziphumo ezibi zempilo.

Ukutya okuphezulu ePhenylalanine

Ukutya okuninzi kuqulethe i-phenylalanine, kubandakanya zombini iimveliso zezityalo kunye nezilwanyana.

Iimveliso zesoya zezinye zezona mithombo zezityalo zibalaseleyo zale asidi yeamino, kunye nembewu ethile kunye namandongomane, kubandakanya iimbotyi zesoya, iimbewu zethanga kunye nembewu yomngqusho ().

Izongezo zeprotein ye-Soy inokubonelela malunga ne-2.5 gram ye-phenylalanine nge-calorie eyi-200 ekhonzayo (, 29).

Iimveliso zezilwanyana, amaqanda, ukutya kwaselwandle kunye nenyama ethile yimithombo elungileyo, ebonelela ukuya kuthi ga kwi-2-3 yeigram kwi-calorie nganye ye-200 (29).

Ngokubanzi, mhlawumbi awudingi ukukhetha ngokukodwa ukutya okusekwe kumxholo ophezulu we-phenylalanine.

Ukutya iintlobo ngeentlobo zokutya okune-protein eninzi yonke le mini kuya kukubonelela ngayo yonke i-phenylalanine oyifunayo, kunye nezinye ii-amino acid eziyimfuneko.

Ukutya okuninzi, kubandakanya iimveliso zesoya, amaqanda, ukutya kwaselwandle kunye nenyama, ziqulathe i-phenylalanine. Ukutya iintlobo ngeentlobo zokutya okune-protein kuyo yonke le mini kuya kukunika zonke ii-amino acid zomzimba wakho, kubandakanya i-phenylalanine.

Umgca osezantsi

I-Phenylalanine yi-amino acid ebalulekileyo efumaneka kwizityalo nakwizilwanyana.

Inokuba neenzuzo zesifo se-vitiligo yolusu, kodwa uphando ngeziphumo zalo kuxinzelelo, iintlungu okanye ezinye iimeko zikhawulelwe.

Ngokuqhelekileyo kuthathwa njengokukhuselekileyo, kodwa abantu abane-phenylketonuria (PKU) banokuba nemiphumo emibi.