I-Antiphospholipid Syndrome: Yintoni, oonobangela kunye nonyango

Umxholo

• Iimpawu eziphambili kunye neempawu
• Yintoni ebangela isifo
• Uxilongo lwenziwa njani
• Unyango lwenziwa njani
• Unyango ngexesha lokukhulelwa

I-Antiphospholipid Antibody Syndrome, ekwabizwa ngokuba yi Hughes okanye nje i-SAF okanye i-SAAF, sisifo esinqabileyo sokuzimela komzimba esibonakala ngokulula ekwenzeni i-thrombi emithanjeni nakwiimithambo eziphazamisa ukujiya kwegazi, ezinokuthi zikhokelele kwintloko, kubenzima ukuphefumla kunye nentliziyo, umzekelo.

Ngokwesizathu, i-SAF inokuhlelwa ngokweendidi ezintathu eziphambili:

1. Kwiprayimari, apho kungekho sizathu esithile;
2. Esekondari, eyenzeka njengesinye isifo, kwaye ihlala inxulumene neNkqubo yeLupus Erythematosus. I-APS yesibini inokwenzeka, nangona kunqabile ngakumbi, inxulunyaniswa nezinye izifo ezizimela komzimba, ezinje nge-scleroderma kunye ne-rheumatoid arthritis, umzekelo;
3. Intlekele, lolona hlobo luqatha lwe-APS apho i-thrombi yenziwa khona kwiindawo ezi-3 ezahlukeneyo kwisithuba esingaphantsi kweveki.

I-APS inokwenzeka nangaliphi na ixesha nakubini besini, nangona kunjalo ixhaphake kakhulu kwabasetyhini abaphakathi kweminyaka engama-20 nama-50 ubudala. Unyango kufuneka lusekwe ngugqirha oqhelekileyo okanye i-rheumatologist kwaye ijolise ekuthinteleni ukwenziwa kwe-thrombi kunye nokuthintela iingxaki, ngakumbi xa owasetyhini ekhulelwe.

Iimpawu eziphambili kunye neempawu

Iimpawu eziphambili kunye neempawu ze-APS zinxulumene notshintsho kwinkqubo yokuqina kunye nokuvela kwe-thrombosis, eyona iphambili yile:

• Iintlungu zesifuba;
• Ubunzima bokuphefumla;
• Intloko ebuhlungu;
• Isicaphucaphu;
• Ukudumba kwamalungu aphezulu okanye asezantsi;
• Ukunciphisa inani leeplatelet;
• Ukuphumelela ngokukhawuleza kokukhupha isisu okanye utshintsho kwi-placenta, kungekho sizathu esibonakalayo.

Ukongeza, abantu abafunyaniswe ukuba bane-APS kunokwenzeka ukuba babe neengxaki zezintso, isifo sentliziyo okanye ukubetha, umzekelo, ngenxa yokwenziwa kwe-thrombi ephazamisa ukujikeleza kwegazi, ukutshintsha inani legazi elifikelela kumalungu. Qonda ukuba yintoni i-thrombosis.

Yintoni ebangela isifo

I-Antiphospholipid Antibody Syndrome yimeko yokuzimela, oko kuthetha ukuba amajoni omzimba ngokwawo ahlasela iiseli emzimbeni. Kule meko, umzimba uvelisa ii-antiphospholipid antibodies ezihlasela i-phospholipids ekhoyo kwiiseli ezinamafutha, ezenza kube lula kwigazi ukuba lijiye kwaye lenze i-thrombi.

Isizathu esithile sokuba amajoni omzimba avelise olu hlobo lwe-antibody alukaziwa, kodwa kuyaziwa ukuba sisimo esixhaphakileyo kubantu abanezinye izifo ezizimele, ezinje ngeLupus, umzekelo.

Uxilongo lwenziwa njani

Ukuchongwa kwe-Antiphospholipid Antibody Syndrome kuchazwa bubukho bekhrayitheriya enye kunye neelebhu, oko kukuthi, ubukho besifo kunye nokufumanisa ubuncinci begazi emzimbeni.

Phakathi kweendlela zeklinikhi eziqwalaselwe ngugqirha ziziganeko ze-arterial or venous thrombosis, ukuvela kwesisu, ukuzalwa kwangaphambi kwexesha, izifo ezizimele kunye nobukho bemingcipheko ye-thrombosis. Ezi nqobo zeklinikhi kufuneka zingqinwe ngokusebenzisa imaging okanye iimvavanyo zaselebhu.

Ngokubhekisele kwiikhrayitheriya zaselebhu bubukho boluhlobo olunye lwe-antiphospholipid antibody, efana:

• ILupus anticoagulant (AL);
• Anticardiolipin;
• Anti beta2-glycoprotein 1.

Ezi ntsholongwane kufuneka zivavanywe ngamaxesha amabini ahlukeneyo, ngesithuba seenyanga ezi-2 ubuncinci.

Ukuze uxilongo lube ne-APS, kufuneka ukuba zombini iikhrayitheriya ziqinisekiswe ngoviwo olwenziwe kabini ngekhefu elingangeenyanga ezintathu.

Unyango lwenziwa njani

Nangona kungekho lunyango lunokunyanga i-APS, kunokwenzeka ukunciphisa umngcipheko wokubumba kwamahlwili kwaye, ngenxa yoko, ukubonakala kweengxaki ezinje nge-thrombosis okanye infarction, ngokusetyenziswa rhoqo kwamachiza anticoagulant, anjengeWarfarin, eyomlomo Sebenzisa, okanye iHeparin, eyenzelwe ukusetyenziswa kwegazi.

Uninzi lwexesha, abantu abane-APS abafumana unyango nge-anticoagulants bayakwazi ukuphila ubomi obuqhelekileyo, kubalulekile ukuba ubonane rhoqo nogqirha ukuze uhlengahlengise idosi yamayeza, xa kukho imfuneko.

Nangona kunjalo, ukuqinisekisa ukuba unyango luyaphumelela, kusabalulekile ukunqanda ezinye iindlela zokuziphatha ezinokuphazamisa iziphumo ze-anticoagulants, njengoko kunjalo ngokutya ukutya okune-vitamin K, njengespinatshi, ikhaphetshu okanye i-broccoli, umzekelo. Jonga ezinye iindlela zokukhusela ekufuneka uzenzile xa usebenzisa ii-anticoagulants.

Unyango ngexesha lokukhulelwa

Kwezinye iimeko ezithile, ezinje ngexa lokukhulelwa, ugqirha unokucebisa ukuba unyango lwenziwe ngeHeparin ejoyiweyo enxulunyaniswa ne-Aspirin okanye i-Immunoglobulin efakwa ngaphakathi, ukuthintela ukubakho kweengxaki ezinjengokukhupha isisu, umzekelo.

Ngonyango olufanelekileyo, kukho amathuba amahle okuba umfazi okhulelweyo one-APS abe nokukhulelwa okuqhelekileyo, nangona kunjalo kuyafuneka ukuba abekwe iliso kufutshane nengcali yokubelekisa, kuba usemngciphekweni omkhulu wokukhulelwa kwesisu, ukuzalwa ngaphambi kwexesha okanye i-pre-eclampsia. Funda indlela yokuqonda iimpawu zepreeclampsia.