Ozanimod

Umxholo

• Ngaphambi kokuba uthathe i-ozanimod,
• I-Ozanimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-ozanimod kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Ozanimod isetyenziselwa ukunyanga abantu abadala ngeendlela eziphinda ziphindaphindwe ze-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha, kunye neengxaki ngombono, intetho, kunye nolawulo lwesinyi) kubandakanya Iiklinikhi ezizimeleyo zesifo (i-CIS; iimpawu zeempawu zemithambo-luvo ezihlala ubuncinci iiyure ezingama-24), iifom zokuphindaphinda-ukubuyisa (ikhosi yesifo apho iimpawu zivela khona amaxesha ngamaxesha), okanye iifom zesekondari eziqhubekayo (ikhosi yesifo apho ukubuyela umva kwenzeka rhoqo). I-Ozanimod ikudidi lwamayeza abizwa ngokuba yi-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.

I-Ozanimod iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Thatha i-ozanimod malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ozanimod ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuginya njengezingxobo ngokupheleleyo; sukuwavula, uwahlafune, okanye uwaqhekeze.

Ugqirha wakho uya kukuqala ngedosi esezantsi yeozanimod kwaye ngokuthe ngcembe wandise idosi yakho kwiveki yokuqala.

I-Ozanimod inokunceda ukulawula iimpawu ze-sclerosis, kodwa ayizinyangi. Ugqirha wakho uyakukujonga ngononophelo ukuze ubone ukuba isebenza njani i-ozanimod. Kubalulekile ukuxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ozanimod kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ozanimod,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-ozanimod, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-ozanimod. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-MAO inhibitor efana ne-isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), okanye tranylcypromine (iParnate) okanye uyekile ukuthatha enye la mayeza kwezi veki zimbini zidlulileyo. Ugqirha wakho uya kuthi akuxelele i-ozanimod ngeli xesha. Ukuba uyeka ukuthatha i-ozanimod, kuya kufuneka ulinde ubuncinci iintsuku ezili-14 ngaphambi kokuba uqale ukuthatha i-MAO inhibitor.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: clopidogrel (Plavix); icyclosporine (Gengraf, Neoral, Sandimmune); I-eltrombopag (iPractacta); erythromycin (EES, Erythromycin, abanye); gemfibrozil (iLopid); amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), procainamide, kunye nequinidine (eNuedexta); i-opioid (i-narcotic) iyeza zentlungu ezinje nge-meperidine (Demerol), imethadone (iDolophine, iMethadose), kunye ne-tramadol; rifampin (Rifadin, Rimactane, eRifamate, abanye); i-inhibitors ekhethiweyo ye-serotonin-reuptake inhibitors enjenge citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), kunye sertraline (Zoloft); kunye ne-serotonin kunye ne-norepinephrine reuptake inhibitors enje nge-desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), milnacipran (Savella), kunye ne-venlafaxine (Effexor); kunye ne-sotalol (iBetapace, iSorine, iSotylize). Xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo, okanye ukuba uwathathe kutshanje: alemtuzumab (Campath, Lemtrada); ii-corticosteroids ezinjenge-dexamethasone, i-methylprednisolone (iMedrol), kunye ne-prednisone (iRayos); amayeza omhlaza; kunye namayeza okwenza buthathaka okanye ukulawula amajoni omzimba afana ne-glatiramer (iCopaxone, iGlatopa) kunye ne-interferon beta (iBetaseron, i-Extavia, iPlegridy). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-ozanimod, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wahlaselwa sisifo sentliziyo, iintlungu esifubeni, ukubetha okanye ukubetha kancinci, okanye ukusilela kwentliziyo kwiinyanga ezi-6 ezidlulileyo. Kwakhona xelela ugqirha wakho ukuba unentliziyo engavumelekanga engalungiswanga yipememaker, okanye ukuba ulala ne-apnea yokulala (ukuyeka ukuphefumla ixesha elifutshane ngexesha lokulala). Ugqirha wakho uya kukuxelela ukuba ungathathi i-ozanimod.
• xelela ugqirha wakho ukuba ngaba unefiva, umqala obuhlungu, ukhohlokhohlo, ukugodola, amadlala adumbileyo, okanye ezinye iimpawu zosulelo, ukuba unesifo esiza kwaye sihamba okanye esingahambiyo, okanye ukuba awukwazi ukulwa nosulelo ngenxa yesinye isifo. Kwakhona xelela ugqirha wakho ukuba ukhe wanalo uxinzelelo oluphezulu lwegazi, ukubetha kwentliziyo kancinci, isifo seswekile, uveitis (ukudumba kwamehlo) okanye ezinye iingxaki zamehlo, okanye isifo sentliziyo okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye ne-ozanimod kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Ukuba ukhulelwe ngelixa uthatha i-ozanimod, biza ugqirha ngokukhawuleza.
• xelela ugqirha wakho ukuba ugonyo kwiintsuku ezingama-30 ezidlulileyo ngaphambi kokuba uqale unyango lwakho ngeozanimod. Awunalo ugonyo ngexesha lonyango okanye iinyanga ezi-3 emva kwedosi yakho yokugqibela ungakhange uthethe nogqirha wakho.
• xelela ugqirha wakho ukuba awukaze ube nenkukhu kwaye awufumananga isitofu sokugonya (varicella). Ugqirha wakho unokuyalela uvavanyo lwegazi ukuze abone ukuba ubonakalisiwe na kwirhashalala. Unokufuna ukufumana isitofu sokugonya kwenkukhu kwaye ulinde inyanga e-1 ngaphambi kokuba uqale unyango lwakho nge-ozanimod.
• Kuya kufuneka uyazi ukuba i-ozanimod inokubangela ukuba nesiyezi, ukuba nentloko elula, kunye nokuphelelwa ngamandla xa usukuma ngokukhawuleza kwindawo olele kuyo. Oku kuqheleke ngakumbi xa uqala ukuthatha i-ozanimod. Ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume.

Unokufumana impendulo enzulu ukuba utya ukutya okuphezulu kwi-tyramine ngexesha lonyango lwakho lwe-ozanimod. I-Tyramine ifumaneka kukutya nakwiziselo ezininzi, kubandakanya inyama, iinkukhu, intlanzi, okanye itshizi etshayiweyo, endala, egcinwe ngokungafanelekanga, okanye eyonakeleyo; iziqhamo ezithile, imifuno, neembotyi; iziselo ezinxilisayo; kunye nemveliso yegwele enegwele. Ugqirha wakho okanye ugqirha otya ukutya okutyayo uya kukuxelela ukuba kukuphi ukutya ekufuneka ukuphephe ngokupheleleyo, kunye nokutya onokukutya ngexabiso elincinci. Ukuba utya ukutya okuphezulu kwi-tyramine ngelixa uthatha i-ozanimod, nxibelelana nogqirha wakho.

Ukuba uphosa idosi enye okanye nangaphezulu ngeentsuku zokuqala ezili-14 zonyango, thetha nogqirha wakho ngaphambi kokuba uqale kwakhona. Uya kudinga ukuqala kwakhona amayeza kwidosi esezantsi kwaye unyuse ngokuthe ngcembe idosi.

Ukuba uphosa idosi emva kweentsuku ezili-14 zokuqala zonyango, qhubeka neshedyuli yakho yethosi rhoqo ngosuku olulandelayo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ozanimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• umqolo obuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-ozanimod kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, ukukhohlela, umqala obuhlungu, impumlo ebusayo, okanye ukubola okuchaphazeleka rhoqo kunye nokunyanga ukuya kuthi ga kwiinyanga ezi-3 emva kwedosi yakho yokugqibela
• intloko ebuhlungu, ukuqina kwentamo, umkhuhlane, ubuntununtunu ekukhanyeni, isicaphucaphu, okanye ukudideka ngexesha lonyango ukuya kuthi ga kwiinyanga ezi-3 emva kwedosi yakho yokugqibela
• isicaphucaphu, ukugabha, ukungabinamdla wokutya, iintlungu esiswini, ubumthubi besikhumba okanye amehlo, okanye umchamo omnyama
• ukufiphala, izithunzi, okanye indawo engaboniyo kumbono wombono wakho; uvakalelo ekukhanyeni; umbala ongaqhelekanga kumbono wakho okanye ezinye iingxaki zombono
• intloko ebukhali ngesiquphe, ukudideka, utshintsho kumbono, okanye ukuxhuzula
• ubuthathaka kwelinye icala lomzimba okanye ubucukubhede beengalo okanye imilenze eya isiba mandundu ngokuhamba kwexesha; utshintsho kwindlela ocinga ngayo, kwimemori, okanye kulungelelwano; ukudideka okanye utshintsho kubuntu; okanye ukuphelelwa ngamandla
• irhashalala; imihlathi okanye ukudumba kwemilebe, ubuso, okanye ulwimi
• okutsha okanye okuya kusiba mandundu nokuphefumla okufutshane
• isiyezi, ukudinwa, iintlungu esifubeni, okanye ukubetha kwentliziyo okucothayo okanye okungaqhelekanga

I-Ozanimod inokunyusa umngcipheko wokuba nomhlaza wolusu. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

Ukonyuka ngesiquphe kweziqendu zeempawu ze-MS kunye nokwanda kokukhubazeka kunokwenzeka emva kokuba uyeke ukuthatha i-ozanimod. Tshela ugqirha wakho ukuba ngaba iimpawu zakho ze-MS ziya zisiba mbi emva kokuba uyeke ukuthatha i-ozanimod.

I-Ozanimod inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Uya kufumana i-electrocardiogram (i-ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) ngaphambi kokuba uthathe idosi yakho yokuqala. Ugqirha wakho uya ku-odola uvavanyo oluthile lweelebhu, iimviwo zamehlo, kwaye uya kubeka esweni uxinzelelo lwegazi ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile ukuba uqale ukuthatha okanye uqhubeke nokuthatha i-ozanimod.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Zeposia^®