Ukuthatha i-Biologics kunye nokuFumana kwakhona uLawulo lweArthritis yakho ye-Psoriatic

Umxholo

• Yintoni i-biologics?
• Iindidi zebhayoloji
• Abatacept
• UAdalimumab
• Isiqinisekiso sephegol
• Etanercept
• IGolimumab
• Infliximab
• Ustekinumab
• Unyango lwendibaniselwano
• Iziphumo ebezingalindelekanga kunye nezilumkiso
• I-Biologics yinxalenye yesicwangciso solawulo lwe-PsA

Ushwankathelo

I-Psoriatic arthritis (i-PsA) yimeko engapheliyo, kwaye unyango oluqhubekayo luyafuneka ukukhusela umonakalo odibeneyo. Unyango olululo lunokunciphisa inani le-arthritis flare-ups.

I-Biologics luhlobo nje olunye lonyango olusetyenziselwa ukunyanga iPSA. Oku kusebenza ngokucinezela amajoni akho omzimba ukuze iyeke ukuhlasela amalungu asempilweni kunye nokwenza iintlungu nomonakalo.

Yintoni i-biologics?

I-Biologics zii-subtypes zezifo eziguqula amachiza e-antirheumatic (DMARDs). Ii-DMARD ziyeke amajoni akho omzimba ekubangeleni ukudumba kwe-PsA kunye nezinye iimeko ezizimeleyo.

Ukunciphisa ukudumba kunemiphumo emibini:

• Kunokubakho iintlungu ezincinci kuba ukudumba kwiindawo ezidibeneyo kungunobangela wendibaniselwano.
• Umonakalo unokuncitshiswa.

Umsebenzi we-Biologics ngokuthintela ama-immune system protein avelisa ukudumba. Ngokungafaniyo nee-DMARDs, ii-biologics zilawulwa ngokufakwa okanye ngenaliti kuphela.

I-Biologics imiselwe njengonyango lodidi lokuqala kubantu abane-PsA esebenzayo. Ukuba i-biologic yokuqala oyizamayo ayizinciphisi iimpawu zakho, ugqirha wakho angakutshintshela kwichiza elahlukileyo kule klasi.

Iindidi zebhayoloji

Iindidi ezine zebhayoloji zisetyenziselwa ukunyanga iPSA:

• I-tumor necrosis factor-alpha (TNF-alpha) inhibitors: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi Aria), infliximab (Remicade)
• I-interleukin 12/23 (IL-12/23) inhibitors: ustekinumab (Stelara)
• I-interleukin 17 (IL-17 inhibitors): ixekizumab (Taltz), secukinumab (Cosentyx)
• Iseli inhibitors: i-abatacept (i-Orencia)

La machiza anokuthintela iiproteni ezithile ezibonisa ukuba amajoni akho omzimba ahlasela iiseli ezisempilweni, okanye ajolise kwiiseli zomzimba ezichaphazelekayo kwimpendulo yokuvuvukala. Injongo nganye ye-biologic subtype kukuthintela inkqubo yokuvuvukala ukuqala.

Iibhayoloji ezininzi ziyafumaneka. Oku kulandelayo zezona ziqhelekileyo zichazwe kwi-PsA.

Abatacept

I-Abatacept (i-Orencia) yi-T yeseli inhibitor. Iiseli T ziiseli ezimhlophe zegazi. Badlala indima kwimpendulo yomzimba yokuzikhusela, nasekubangeleni ukudumba. I-Orencia ijolise kwiiseli ze-T ukuzisa ukudumba.

I-Orencia ikwanyanga isifo samathambo (RA) kunye ne-juvenile idiopathic arthritis (JIA). Iyafumaneka njengokufakwa ngomthambo, okanye ngenaliti ozinika yona.

UAdalimumab

I-Adalimumab (Humira) isebenza ngokuthintela i-TNF-alpha, iprotein ekhuthaza ukudumba. Abantu abane-PsA bavelisa kakhulu i-TNF-alpha kulusu kunye namalungu abo.

I-Humira yonyango elitofwayo. Ikwachazwe kwisifo sikaCrohn kunye nezinye iindlela zesifo samathambo.

Isiqinisekiso sephegol

I-Certolizumab pegol (Cimzia) lelinye ichiza le-TNF-alpha. Yenzelwe ukunyanga iifom zobundlongondlongo ze-PsA, kunye nesifo sikaCrohn, RA, kunye ne-ankylosing spondylitis (AS).

I-Cimzia inikezelwa njenge-self-injection.

Etanercept

I-Etanercept (i-Enbrel) ikwayiyeza le-TNF-alpha. Kuphakathi kwamachiza amadala avunyiweyo kunyango lwe-PsA, kwaye isetyenziselwa ukunyanga ezinye iindlela zesifo samathambo.

I-Enbrel itofelwe ngokwakho izihlandlo ezibini ngeveki.

IGolimumab

IGolimumab (iSimponi) sisiyobisi se-TNF-alpha esenzelwe ukunyanga i-PsA esebenzayo. Ikwacwangciselwe i-RA yokumodareyitha ukuya kubukrakra, ulcerative colitis (UC), kunye ne-AS esebenzayo.

Uthatha uSimponi kanye ngenyanga ngokuzitofa ngokwakho.

Infliximab

I-infliximab (Remicade) yinguqulelo yokumiliselwa yeyeza le-TNF-alpha. Ukufumana ukumnika kwi-ofisi kagqirha kathathu kwiiveki ezintandathu. Emva konyango lokuqala, ukumiliselwa kunikwa rhoqo kwiinyanga ezimbini.

I-Remicade ikwanyanga isifo sikaCrohn, i-UC, kunye ne-AS. Oogqirha banokumisela i-RA, kunye ne-methotrexate.

Ixekizumab

Ixekizumab (Taltz) yi-IL-17 inhibitor. Ibhloka i-IL-17, ebandakanyeka ekuphenduleni komzimba.

Ufumana i-Taltz njengoluhlu lweenaliti phantsi kolusu rhoqo kwiiveki ezimbini, kwaye emva kweeveki ezine.

Ukhuseleko

I-Secukinumab (iCosentyx) yenye ye-IL-17 inhibitor. Yamkelwe ukunyanga i-psoriasis kunye ne-PsA, kunye ne-AS.

Uyithatha njengesithonga phantsi kolusu lwakho.

Ustekinumab

Ustekinumab (Stelara) yi-IL-12/23 inhibitor. Ibhloka iiprotein IL-12 kunye ne-IL-23, ebangela ukudumba kwi-PsA. U-Stelara uvunyiwe ukuba anyange i-PsA esebenzayo, i-plaque psoriasis, kunye nesifo sika-Crohn's.

UStelara uza njenaliti. Emva kwenaliti yokuqala, yenziwa kwakhona emva kweeveki ezine, kwaye kanye emva kweeveki ezili-12.

Unyango lwendibaniselwano

Ukumodareyitha ukuya kwi-PsA emodareyitha, i-biologics ibalulekile ekulawuleni zombini iimpawu zexesha elifutshane kunye nexesha elide kunye neengxaki. Nangona kunjalo, ugqirha wakho unokucebisa nolunye unyango.

Ugqirha wakho unokukunika amayeza angasebenziyo (anti-inflammatory) (i-NSAID) kwiintlungu. Oku kunciphisa nokudumba. Iinguqulelo ezingaphezulu kwe-counter (OTC), ezinje nge-ibuprofen (Advil), ziyafumaneka ngokubanzi, kunye neefomula zamandla kagqirha.

Ukusetyenziswa kwexesha elide kunokunyusa umngcipheko wokuphuma kwesisu, iingxaki zentliziyo, kunye nokubetha, ii-NSAID kufuneka zisetyenziswe kancinci nakwidosi esezantsi.

Ukuba une-psoriasis ngaphambi kwe-PsA, emva koko unokufuna iindlela zonyango zokunceda ekunciphiseni irhashalala kunye neengxaki zesikhonkwane. Unyango olunokubakho lubandakanya i-corticosteroids, unyango olukhanyayo, kunye neoli yokuthambisa.

Iziphumo ebezingalindelekanga kunye nezilumkiso

Iziphumo ebezingalindelekanga ezixhaphakileyo ze-biologics kukusabela kolusu (njengokubomvu kunye nerhashalala) kwindawo yenaliti. Ngenxa yokuba i-biologics ilawula amajoni akho omzimba, unokuba semngciphekweni omkhulu wokufumana usulelo.

Okungaqhelekanga, kodwa okubi, iziphumo ebezingalindelekanga zibandakanya:

• i-psoriasis eyandayo
• usulelo oluphezulu lokuphefumula
• isifo sephepha
• Iimpawu ezinje nge-lupus (ezinje ngemisipha kunye nentlungu edibeneyo, umkhuhlane kunye nokulahleka kweenwele)

Thetha kwi-rheumatologist malunga nale miphumo emibi, kwaye uqaphele imeko yakho ngokucophelela. Tsalela umnxeba ngoko nangoko ukuba ukrokrela ukuba unempendulo engalunganga kumayeza akho.

Kwakhona, abasetyhini abakhulelweyo okanye abaceba ukukhulelwa kufuneka basebenzise i-biologics ngononophelo.

Nangona iimpembelelo kumntwana okhulayo zingaqondwa ncam, kunokwenzeka ukuba kubekho iingxaki xa ukhulelwe. Kuxhomekeke kubukhali be-PsA, abanye oogqirha bacebisa ukuyeka unyango ngexesha lokukhulelwa.

I-Biologics yinxalenye yesicwangciso solawulo lwe-PsA

I-Biologics izisa ithemba kwabaninzi nge-PsA. Ayaneli kunceda kuphela i-biologics ekuncedeni ukulawula iimpawu ze-PsA, zikwanciphisa imeko eyonakalisayo yesifo esidala.

Okwangoku, kubalulekile ukuba ukhumbule ukuba i-biologics yinxalenye enye kuphela yesicwangciso sakho solawulo lwe-PsA lwexesha elide. Thetha nogqirha wakho malunga notshintsho kwindlela yokuphila kunye namanye amayeza anokunceda.