Yintoni iTrimetazidine?

Umxholo

• Kusetyenziswa kwanjani
• Yeyiphi indlela yokusebenza
• Ngubani ongafanele asebenzise
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-Trimetazidine yinto esebenzayo ebonakaliswe kunyango lwe-ischemic heart failure kunye nesifo sentliziyo esisischemic, esisifo esibangelwa kukusilela ekujikelezeni kwegazi kwimithambo.

I-Trimetazidine inokuthengwa ezikhemesti ngexabiso elimalunga ne-45 ukuya kwi-107 reais, xa kunikwa amayeza.

Kusetyenziswa kwanjani

Umthamo ocetyiswayo yipilisi enye ye-35 mg, kabini ngemini, kanye kusasa, ngexesha lesidlo sakusasa nakanye ngokuhlwa, ngexesha lesidlo sangokuhlwa.

Yeyiphi indlela yokusebenza

I-Trimetazidine igcina imetabolism yamandla eeseli zeischemic, ezivezwa kukuxinana kweoksijini ephantsi, kuthintela ukwehla kwamanqanaba e-intracellular e-ATP (amandla), ngaloo ndlela kuqinisekiswe ukusebenza kakuhle kweempompo ze-ionic kunye nokuhamba kwe-transmembrane yesodium kunye ne-potassium, ngelixa kugcinwa iseli ye-homeostasis.

Olu londolozo lwe-metabolism yamandla lufezekiswa ngokuthintela i-β-oxidation ye-fatty acids, eyenziwa yi-trimetazidine, eyonyusa i-oxidation yeswekile, eyindlela yokufumana amandla afuna ukusetyenziswa kweoksijini encinci xa kuthelekiswa nenkqubo ye-ation-oxidation. Ke, ukubakho kwe-glucose oxidation kwandisa inkqubo yamandla eselfowuni, kugcinwe imetabolism yamandla efanelekileyo ngexesha le-ischemia.

Kwizigulana ezinesifo sentliziyo, i-trimetazidine isebenza njenge-metabolic agent egcina amanqanaba e-intracellular e-myocardial energy high phosphates.

Ngubani ongafanele asebenzise

Eli yeza liyaphikiswa kwizigulana ezine-hypersensitivity to trimetazidine okanye naliphi na icandelo lefomula, abantu abanesifo sikaParkinson, iimpawu zeparkinsonism, ukungcangcazela, isifo somlenze ongazinzanga kunye nolunye utshintsho olunxulumene nentshukumo kunye nokusilela kakhulu kwezintso ngokususwa kwe-creatinine ngaphantsi kwe-30mL / imiz.

Ukongeza, eli yeza akufuneki lisetyenziswe ngabantwana abangaphantsi kwe-18, abasetyhini abakhulelweyo okanye abasetyhini abancancisayo.

Iziphumo ebezingalindelekanga ezinokwenzeka

Ezinye zeziphumo ebezingalindelekanga ezinokubakho ngexesha lonyango nge-trimetazidine sisiyezi, intloko ebuhlungu, iintlungu esiswini, urhudo, ukugaya ukutya okungafunekiyo, isicaphucaphu, ukugabha, irhashalala, ukurhawuzelela, urhwaphilizo kunye nokuba buthathaka.