VIPoma

I-VIPoma ngumhlaza onqabileyo odla ngokukhula ukusuka kwiiseli zepancreas ezibizwa ngokuba ziiseli zeislet.

I-VIPoma ibangela ukuba iiseli zepancreas zivelise inqanaba eliphezulu lehomoni ebizwa ngokuba yi-vasoactive intestinal peptide (VIP). Le hormone inyusa ukhuseleko emathunjini. Ikwabuyisela kwakhona ezinye izihlunu ezigudileyo kwinkqubo yamathumbu.

Isizathu ngqo seVIPomas asaziwa.

Ii-VIPomas zihlala zifunyaniswa kubantu abadala, zixhaphake kakhulu xa zineminyaka engama-50. Abasetyhini ngabona bachaphazeleka kunamadoda. Lo mhlaza unqabile. Unyaka ngamnye, malunga ne-1 kwizigidi ezili-10 zabantu abafunyaniswa bene-VIPoma.

Iimpawu zeVIPoma zinokubandakanya oku kulandelayo:

• Iintlungu zesisu kunye necramping
• Urhudo (amanzi, kwaye amaxesha amaninzi ngesixa esikhulu)
• Ukuphelelwa ngamanzi emzimbeni
• Ukugungxula okanye ukuba bomvu kobuso
• Iikhram zesisu ngenxa yegazi potassium ephantsi (hypokalemia)
• Isicaphucaphu
• Ukuhla ukusinda

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga nembali yakho yonyango kunye neempawu.

Uvavanyo olunokwenziwa lunokubandakanya:

• Uvavanyo lweekhemesti yegazi (iphaneli esisiseko okanye ebanzi yemetabolic)
• Ukuvavanywa kwe-CT kwesisu
• I-MRI yesisu
• Uviwo lwe-Stool ngesizathu sohudo kunye namanqanaba e-electrolyte
• Inqanaba le-VIP egazini

Injongo yokuqala yonyango kukulungisa ukungabikho komzimba. Ulwelo ludla ngokunikwa ngomthambo (ulwelo olufakwa ngaphakathi) ukufaka endaweni yeencindi ezilahlekileyo ngenxa yorhudo.

Injongo elandelayo kukucotha urhudo. Amayeza anokunceda ukulawula urhudo. Elinye lala machiza yi-octreotide. Yifom eyenziwe ngabantu yehomoni yendalo ethintela isenzo seVIP.

Elona thuba lilungileyo lonyango ngotyando lokususa ithumba. Ukuba ithumba alinwenwanga kwamanye amalungu, utyando lunokuyinyanga imeko.

Ungaluphelisa uxinzelelo lokugula ngokujoyina iqela lokuxhasa umhlaza. Ukwabelana nabanye abanamava afanayo kunye neengxaki kunokukunceda ungaziva ulilolo.

Ugqirha lunokunyanga i-VIPomas. Kodwa, kwisinye kwisithathu ukuya kwisiqingatha sabantu, ithumba lisasazeke ngexesha lokuchongwa kwaye alinakunyangeka.

Iingxaki zinokubandakanya:

• Ukusasazeka komhlaza (metastasis)
• Ukubanjwa kwe-Cardiac kwinqanaba eliphantsi le-potassium yegazi
• Ukuphelelwa ngamanzi emzimbeni

Ukuba unorhudo olunamanzi ngaphezulu kweentsuku ezi-2 ukuya kwezi-3, tsalela umnikezeli wakho umnxeba.

Ithumba elivelisa isisu sepeptide; Isifo seVIPoma; Ipancreatic tumor endocrine

• Iipancreas

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwepancreatic neuroendocrine tumors (islet cell tumors) unyango (PDQ) -uhlobo lobuchwephesha kwezempilo. www.cancer.gov/types/pancreatic/hp/pnet-kunyanga-pdq. Ukuhlaziywa ngoFebruwari 8, 2018. Ifikeleleke ngoNovemba 12, 2018.

Schneider DF, Mazeh H, Lubner SJ, Jaume JC, Chen H. Umhlaza wenkqubo ye-endocrine. Ku: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, ii-eds. I-Oncology yeklinikhi yase-Abeloff. Umhla we-5. IPhiladelphia, PA: Elsevier Saunders; 2014: isahl 71.

UVella A. Amadlala emathunjini kunye namathumbu endocrine esiswini. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 38.