Cholangiocarcinoma

I-Cholangiocarcinoma (CCA) ngumhlaza onqabileyo (onobungozi) wokukhula kwenye yeepayipi ezithwala inyongo ukusuka kwisibindi ukuya emathunjini amancinci.

Isizathu ngqo seCCA asaziwa. Nangona kunjalo, uninzi lwezi tumors sele zihambile kakhulu ngexesha zifunyanwa.

I-CCA ingaqala naphi na ecaleni kwemibhobho yenyongo. Ezi tumors zivimba imibhobho yenyongo.

Bobabini abesilisa nabasetyhini bayachaphazeleka. Uninzi lwabantu badala kunama-65.

Abantu abanezi ngxaki zempilo zilandelayo banokuba namathuba aphezulu okuphuhlisa i-CCA:

• Idreyini yenyani (choledochal) cysts
• Ukudumba okungapheliyo kwe-biliary kunye nesibindi
• Imbali yosulelo ngee-parasitic worms, izibilini zesibindi
• Isiseko se-sclerosing cholangitis
• Ukudumba okwenziwa sisilonda sikabhobhosi

Iimpawu zeCCA zinokubandakanya oku kulandelayo:

• Umkhuhlane kunye nokubanda
• Izitulo zombala wodongwe kunye nomchamo omnyama
• Ukurhawuzelela
• Ukuphelelwa ngumdla wokutya
• Intlungu kwisisu esisekunene esinokuthi sikhuphe ngasemva
• Ukuhla ukusinda
• Ubumthubi besikhumba (i-jaundice)

Umboneleli wakho wezempilo uya kwenza uvavanyo lomzimba. Kuya kwenziwa iimvavanyo ukukhangela ithumba okanye ukuvaleka kwendlela ye-bile. Oku kunokubandakanya:

• Ukuskena kwe-CT esiswini
• I-ultrasound yesisu
• Inkqubo esebenzisa umda wokubukela ukujonga i-bile ducts (ERCP), ngexesha apho izicubu zinokuthathwa zijongwe phantsi kwemicroscope

Uvavanyo lwegazi olunokwenziwa lunokubandakanya:

• Uvavanyo lomsebenzi wesibindi (ngakumbi i-alkaline phosphatase okanye amanqanaba ebilirubin)
• Gcwalisa ubalo lwegazi (CBC)

Injongo kukunyanga umhlaza kunye nokubhloka okubangelwa kuko. Xa kunokwenzeka, utyando lokususa ithumba lunyango lokhetho kwaye kunokubangela unyango. Rhoqo umhlaza sele usasazekile apha ekhaya okanye kwenye indawo yomzimba ngelixesha ufunyenwe ngalo. Ngenxa yoko, utyando lokunyanga umhlaza alunakwenzeka.

I-Chemotherapy okanye i-radiation inokunikwa emva kotyando ukunciphisa umngcipheko wokubuya komhlaza.

Kwiimeko ezikhethiweyo, ukufakelwa kwesibindi kunokuzama.

Unyango lwe-Endoscopic ngokufakwa kwe-stent okwethutyana kunokususa ukubhloka kwimibhobho ye-biliary. Oku kunokususa i-jaundice xa ithumba lingenakususwa.

Ukususa ngokupheleleyo ithumba kuvumela abanye abantu ukuba baphile benonyango olupheleleyo.

Ukuba ithumba alinakususwa ngokupheleleyo, unyango alunakwenzeka. Ngonyango, malunga nesiqingatha sabantu abachaphazelekayo baphila unyaka, kwaye malunga nesiqingatha siphila ixesha elide, kodwa kunqabile ukuba kudlule iminyaka emi-5.

IHospice ihlala iluncedo kubantu abaneCCA engenakunyangeka.

Iingxaki zeCCA zibandakanya:

• Usulelo
• Ukungaphumeleli kwesibindi
• Ukusasazeka (i-metastasis) yethumba kwamanye amalungu

Biza umnikezeli wakho ukuba une-jaundice okanye ezinye iimpawu ze-cholangiocarcinoma.

Umhlaza wamanzi omhlaza

• Inkqubo yokwetyisa
• Indlela yendlela

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwe-Bile duct cancer (cholangiocarcinoma) unyango (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/types/liver/hp/bile-duct-kunyanga-pdq. Ukuhlaziywa kweSeptemba 23, 2020. Ifikeleleke ngoNovemba 9, 2020.

URajkomar K, uKoea JB. I-Intrahepatic cholangiocarcinoma. Ku: Jarnagin WR, ed. Utyando lukaBlumgart lweSibindi, iTeknoloji yeBiliary kunye neePancreas. Umhla wesi-6. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 50.

URizvi SH, Gores GJ. Amathumba emibhobho yenyongo, inyongo, kunye ne-ampulla. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 69.