I-Avapritinib

Umxholo

• Ngaphambi kokuba uthathe i-avapritinib,
• I-Avapritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-avapritinib kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

I-Avapritinib isetyenziselwa ukunyanga uhlobo oluthile lwesisu esiswini (GIST; uhlobo lwethumba elikhula eludongeni lwesisu, amathumbu [amathumbu], okanye umqala [ityhubhu edibanisa umqala nesisu]) kubantu abadala isasazeka kwamanye amalungu omzimba okanye ayinakususwa ngotyando. I-Avapritinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

I-Avapritinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye yonke imihla ngaphandle kwesisu, ubuncinci iyure enye ngaphambi kunye neeyure ezi-2 emva kwesidlo. Thatha i-avapritinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-avapritinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uyagabha emva kokuthatha i-avapritinib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho anganciphisa i-avapritinib dose okanye ayeke unyango lwakho kuxhomekeke ekusebenzeni kakuhle kweyeza kwaye ukuba unemiphumo emibi. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-avapritinib. Sukuyeka ukuthatha i-avapritinib ungakhange uthethe nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-avapritinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-avapritinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-avapritinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya oku kulandelayo: aprepitant (Emend); amayeza athile okubulala anjenge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), okanye ketoconazole; i-clarithromycin (i-Biaxin, kwi-Prevpac); diltiazem (Cardizem, Tiazac, abanye); erythromycin (EES, Erythrocin, abanye); amayeza athile e-HIV afana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, abanye), okanye saquinavir (Invirase); imodafinil (Provigil); nefazodone; oxcarbazepine (iTrileptal); phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos, eActoplus, eDuetact, eOseni); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, kwiRifater); kunye ne-verapamil (Calan). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.Amanye amayeza amaninzi anokusebenzisana ne-avapritinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango kunye nakwiiveki ezi-6 emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiiveki ezi-6 emva kwethamo lakho lokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-avapritinib, biza ugqirha wakho ngokukhawuleza. I-Avapritinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa uthatha i-avapritinib kwaye ubuncinci iiveki ezi-2 emva kwedosi yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga neengozi zokuthatha i-avapritinib.
• Kuya kufuneka uyazi ukuba i-avapritinib inokukwenza ube nesiyezi, uzele, okanye udideke. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba idosi elandelayo ibangelwe ngaphantsi kweeyure eziyi-8, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Avapritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isisu esibuhlungu
• ukugabha
• isicaphucaphu
• urhudo
• isilungulela
• intloko ebuhlungu
• ukudinwa
• ubunzima bokulala okanye ukulala
• ukulahleka kweenwele
• utshintsho lombala weenwele
• ukuhla ukusinda
• Amehlo aneenyembezi
• utshintsho lwencasa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-avapritinib kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ukudumba kobuso, amehlo, umlomo, okanye umqala
• ukudumba kwezandla, amaqatha okanye iinyawo
• ukugabha igazi okanye izinto ezibonakala ngathi ziindawo zekofu okanye ezibomvu okanye ezilindileyo izitulo ezimnyama
• intloko ebuhlungu, iingxaki zombono, ukozela, ukudinwa kakhulu, okanye ubuthathaka kwelinye icala lomzimba wakho
• ukulibala, ukudideka, ukozela, isiyezi, ubunzima bokulala, ubunzima bokuthetha, ukubona izinto ezingekhoyo, okanye ukutshintsha kwemood okanye isimilo.
• irhashalala
• ukuqhawukelwa ngumphefumlo
• umkhuhlane okanye ezinye iimpawu zosulelo

I-Avapritinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obugqithisileyo kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa na nge-avapritinib. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-avapritinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ayvakit^®