Uninzi lwe-endocrine neoplasia (MEN) I

Uhlobo lwe-endocrine neoplasia (MEN) lohlobo I sisifo apho elinye okanye ngaphezulu kwamadlala endocrine asebenza kakhulu okanye enza isimila. Idluliselwa kwiintsapho.

Amadlala e-Endocrine ahlala echaphazeleka kubandakanya:

• Iipancreas
• IParathyroid
• Indawo yobomi

AMADODA Ndibangelwa sisiphene kwimfuza ephethe ikhowudi yeprotein ebizwa ngokuba yimenin. Imeko ibangela ukuba amathumba amadlala ahlukeneyo avele kumntu omnye, kodwa hayi ngexesha elinye.

Esi sifo sinokuvela nangaliphi na ixesha, kwaye sichaphazela amadoda nabafazi ngokulinganayo. Imbali yosapho yesi sifo iphakamisa umngcipheko.

Iimpawu ziyahluka ukusuka komnye umntu ukuya komnye, kwaye kuxhomekeke ekubeni leliphi na idlala elibandakanyekayo. Banokubandakanya:

• Intlungu zesisu
• Ixhala
• Mnyama, ilindle
• Ukudumba emva kokutya
• Ukutsha, ukuqaqanjelwa, okanye indlala ukungonwabi kwisisu esingaphezulu okanye esifubeni esisezantsi esikhululwe zii-antacids, ubisi okanye ukutya
• Ukunciphisa umdla wesondo
• Ukudinwa
• Intloko ebuhlungu
• Ukungabikho kwexesha lokuya esikhathini (kwabasetyhini)
• Ukuphelelwa ngumdla wokutya
• Ukuphulukana komzimba okanye iinwele zobuso (emadodeni)
• Utshintsho lwengqondo okanye ukudideka
• Intlungu yezihlunu
• Isicaphucaphu nokugabha
• Uvakalelo kubanda
• Ukuphulukana nobunzima ngabom
• Iingxaki zombono
• Ubuthathaka

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze imibuzo malunga nembali yakho yonyango kunye neempawu. Olu vavanyo lulandelayo lunokwenziwa:

• Inqanaba legazi le-cortisol
• Ukuvavanywa kwe-CT kwesisu
• Ukuvavanywa kwentloko kwe-CT
• Ukuzila ukutya iswekile yegazi
• Uvavanyo lwemfuzo
• Uvavanyo lwe-insulin
• I-MRI yesisu
• I-MRI yentloko
• I-serum adrenocorticotropic hormone
• Isalcium calcium
• I-serum follicle ekhuthaza i-hormone
• I-Serum gastrin
• I-Serum glucagon
• I-serum luteinizing hormone
• I-serum hormone yeparathyroid
• Iprolactin yeserum
• I-Serum thyroid ekhuthaza i-hormone
• I-Ultrasound yentamo

Utyando lokususa idlala elinesifo kuhlala lunyango olukhethiweyo. Iyeza elibizwa ngokuba yi-bromocriptine linokusetyenziswa endaweni yoqhaqho lwenzalo yamathumba ekhupha i-hormone prolactin.

Izibilini ze-parathyroid, ezilawula ukuveliswa kwe-calcium, zingasuswa. Nangona kunjalo, kunzima ukuba umzimba ulawule amanqanaba e-calcium ngaphandle kwala madlala, ke ukususwa ngokupheleleyo kweparathyroid akwenziwa okokuqala kwiimeko ezininzi.

Amayeza ayafumaneka ukunciphisa ukuveliswa kwesisu okugqithileyo okubangelwa ngamanye amathumba (gastrinomas), kunye nokunciphisa umngcipheko wezilonda.

Unyango olungena endaweni yeHormone lunikezelwa xa kususwe amadlala onke okanye avelisi iihomoni ezaneleyo.

Izidumba zepituitary kunye neparathyroid zihlala zingenabisi (benign), kodwa ezinye izidumba zepancreatic zinokuba ngumhlaza (ezimbi) kwaye zisasazeka kwisibindi. Oku kunokunciphisa ixesha lokuphila.

Iimpawu zesifo sezilonda zesilonda, iswekile esezantsi yegazi, ikhalsiyam eninzi egazini, kunye nokungasebenzi kakuhle kwamalungu omzimba zihlala ziphendula kakuhle kunyango olufanelekileyo.

Amathumba anokuhlala ebuya. Iimpawu kunye neengxaki zixhomekeke kwizifo ezibandakanyekayo. Ukuhlolwa rhoqo ngumboneleli wakho kubalulekile.

Fowunela umnikezeli wakho ukuba ubona iimpawu ze-MEN I okanye ndinembali yosapho yale meko.

Ukuhlolwa kwezihlobo ezisondeleyo zabantu abachaphazelekayo kwesi sifo kuyacetyiswa.

Isifo seWermer; AMADODA NDI

• Amadlala endocrine

Iwebhusayithi yeNethiwekhi yeCancer epheleleyo yoMhlaza. Isikhokelo sokusebenza kwezonyango kwi-oncology (izikhokelo ze-NCCN): i-neuroendocrine tumors. Inguqulelo 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Ukuhlaziywa ngo-Matshi 5, 2019. Ifikeleleke ngo-Matshi 8, 2020.

Newey PJ, Thakker RV. Uninzi lwee-endocrine neoplasia. Ku: UMelmed S, uAuchus RJ, uGoldfine AB, uKoenig RJ, uRosen CJ, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-14. IPhiladelphia, PA: Elsevier; 2020: isahluko 42.

UNieman LK, uSpiegel AM. Ukuphazamiseka kwePolyglandular. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 218.

I-Thakker RV. Uhlobo lwe-endocrine neoplasia oluninzi 1. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; I-2016: isahluko 148.