I-Cushing syndrome ngenxa yethumba le-adrenal

I-Cushing syndrome ngenxa yethumba le-adrenal luhlobo lwe-Cushing syndrome. Kwenzeka xa ithumba ledlala le-adrenal likhupha izixa ezigqithileyo zehomoni yecortisol.

I-Cushing syndrome sisifo esenzeka xa umzimba wakho ukwinqanaba eliphezulu kune-cortisol yehomoni. Le hormone yenziwa kwiincindi ze-adrenal. I-cortisol eninzi inokubangelwa ziingxaki ezahlukeneyo. Enye yezi ngxaki ithumba kwelinye lamadlala adrenal. Amathumba eAdrenal akhulula i-cortisol.

Amathumba eadrenal anqabile. Bangangabinomdlavuza (benign) okanye umhlaza (umbi).

Amathumba angonakalisiyo anokubangela i-Cushing syndrome ibandakanya:

• Adrenal adenomas, ithumba eliqhelekileyo elingafane lenze i-cortisol engaphezulu
• I-Macronodular hyperplasia, ebangela ukuba i-adrenal glands ikhulise kwaye yenze i-cortisol engaphezulu

Amathumba omhlaza anokubangela i-Cushing syndrome ibandakanya i-adrenal carcinoma. Esi sisifo esinqabileyo, kodwa sihlala sisenza i-cortisol egqithileyo.

Uninzi lwabantu abane-Cushing syndrome bane:

• Ujikeleze, ubomvu, ubuso obugcweleyo (ubuso benyanga)
• Izinga lokukhula kancinci kubantwana
• Ukutyeba ngokonyuka kwamafutha esiqwini, kodwa ukulahleka kwamafutha ezingalweni, emilenzeni nasezimpundu (ukutyeba kakhulu)

Utshintsho lolusu oluhlala lubonwa:

• Usulelo lolusu
• Amanqaku athambileyo (1/2 intshi okanye 1 cm okanye ngaphezulu ububanzi), ebizwa ngokuba yi-striae, kwesikhumba sesisu, amathanga, iingalo eziphezulu kunye namabele
• Ulusu olucekeceke ngokugruzuka ngokulula

Utshintsho lwemisipha kunye nethambo lubandakanya:

• Umqolo obuhlungu, owenzeka ngemisebenzi yesiqhelo
• Intlungu yethambo okanye ukuthamba
• Ukuqokelelwa kwamafutha phakathi kwamagxa nangaphezulu kwethambo lekhola
• Iimbambo kunye nokuqhekeka komqolo okubangelwa kukuncipha kwamathambo
• Izihlunu ezibuthathaka, ngakumbi ezinqeni nasemagxeni

Utshintsho lomzimba ngokubanzi (systemic) lubandakanya:

• Uhlobo lwe-2 yeswekile
• Igazi elonyukayo
• Ukunyusa i-cholesterol kunye ne-triglycerides

Abasetyhini bahlala:

• Ukukhula okungaphezulu kweenwele ebusweni, entanyeni, esifubeni, esiswini nasemathangeni (okuqhelekileyo kunezinye iintlobo zeCushing syndrome)
• Amaxesha angabikho mgaqweni okanye ayeke

Amadoda anokuba:

• Ukunciphisa okanye akukho mnqweno wesini (i-libido ephantsi)
• Iingxaki zokwakhiwa

Ezinye iimpawu ezinokuthi zenzeke zibandakanya:

• Utshintsho lwengqondo, olufana nokudakumba, unxunguphalo, okanye utshintsho kwindlela yokuziphatha
• Ukudinwa
• Intloko ebuhlungu
• Ukwanda ukoma kunye nokuchama

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu zakho.

Uvavanyo lokuqinisekisa isifo seCushing:

• Isampuli yomchamo weeyure ezingama-24 ukulinganisa amanqanaba e-cortisol kunye ne-creatinine
• Uvavanyo lwegazi ukujonga i-ACTH, i-cortisol, kunye nenqanaba le potassium
• Uvavanyo lokucinezelwa kweDexamethasone
• Amanqanaba egazi le-cortisol
• Inqanaba legazi le-DHEA
• Inqanaba le-Saliva cortisol

Uvavanyo lokufumanisa unobangela okanye iingxaki zibandakanya:

• Isisu se-CT
• I-ACTH
• Ubuninzi bamaminerali amathambo
• Icholesterol
• Ukuzila ukutya kweglucose

Utyando lwenziwa ukususa i-adrenal tumor. Rhoqo, le ndlala yonke ye-adrenal iyasuswa.

Unyango lwe-Glucocorticoid lonyango olufunekayo ludla ngokufuneka de ibe enye iadrenal gland ibuye kwakhona kutyando. Unokulufuna olu nyango iinyanga ezi-3 ukuya kwezi-12.

Ukuba utyando alunakwenzeka, njengakwimeko yomhlaza we-adrenal osasazekileyo (i-metastasis), amayeza anokusetyenziselwa ukunqanda ukukhutshwa kwe-cortisol.

Abantu abane-tumor ye-adrenal abaye batyunjwa banembono obalaseleyo. Ngomhlaza we-adrenal, utyando ngamanye amaxesha alunakwenzeka. Xa utyando lwenziwa, akusoloko kunyanga umhlaza.

Amathumba adrenal anomhlaza angasasazeka kwisibindi okanye kwimiphunga.

Fowunela umnikezeli wakho ukuba uphuhlisa naziphi na iimpawu zeCushing syndrome.

Unyango olufanelekileyo lwezihlunu ze-adrenal lunokunciphisa umngcipheko weengxaki kwabanye abantu abane-Cushing syndrome enxulumene ne-adrenal.

Ithumba le-Adrenal-Cushing syndrome

• Amadlala endocrine
• I-Adrenal metastases-CT ukuskena
• Ukudumba kweAdrenal - CT

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UNieman LK, uBiller BM, uKufumana uJW, et al. Unyango lwe-Cushing's syndrome: Isikhokelo sonyango se-Endocrine Society. J Ikliniki ye-Endocrinol Metab. Ngo-2015; 100 (8): 2807-2831. IINKCUKACHA: 26222757 www.ncbi.nlm.nih.gov/pubmed/26222757.

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