Isifo seSjögren

I-Sjögren syndrome kukuphazamiseka komzimba apho amadlala avelisa iinyembezi kunye namathe atshatyalaliswa. Oku kubangela umlomo owomileyo namehlo owomileyo. Le meko inokuchaphazela amanye amalungu omzimba, kubandakanya izintso nemiphunga.

Unobangela weSjögren syndrome awaziwa. Sisifo sokuzimela. Oku kuthetha ukuba umzimba uhlasela izicwili ezisempilweni ngempazamo. Isifo esivela rhoqo kubasetyhini abaneminyaka engama-40 ukuya kwengama-50. Kunqabile ebantwaneni.

Isifo sePrayimari seSjögren sichazwa njengamehlo owomileyo kunye nomlomo owomileyo ngaphandle kwesinye isifo sokuzimela.

Isifo seSjögren sesekondari senzeka kunye nokunye ukuphazamiseka komzimba, njenge:

• Isifo samathambo (RA)
• Inkqubo ye lupus erythematosus
• Iscleroderma
• Polymyositis
• I-Hepatitis C inokuchaphazela amadlala amathe kwaye ijongeka njenge-Sjögren syndrome
• Isifo se-IgG4 sinokujongeka njenge-Sjogren syndrome kwaye kufuneka siqwalaselwe

Amehlo owomileyo kunye nomlomo owomileyo zezona mpawu zixhaphakileyo zesi sifo.

Iimpawu zamehlo:

• Ukurhawuzela amehlo
• Ndiva ukuba kukho into esweni

Umlomo kunye neempawu zomqala:

• Kunzima ukugwinya okanye ukutya ukutya okomileyo
• Ukuphulukana nengqondo yokungcamla
• Iingxaki zokuthetha
• Amathe atyebileyo okanye aluhlu
• Izilonda zomlomo okanye iintlungu
• Ukubola kwamazinyo nokudumba kweentsini
• Ukurhabaxa

Ezinye iimpawu zingabandakanya:

• Ukudinwa
• Ifiva
• Guqula umbala wezandla okanye iinyawo ngokuchasene nokubanda (iRaynaud phenomenon)
• Intlungu edibeneyo okanye ukudumba ngokudibeneyo
• Amadlala adumbileyo
• Ukudumba kolusu
• Ubudenge kunye nentlungu ngenxa ye-neuropathy
• Ukukhohlela nokuphefumla kancinci ngenxa yesifo semiphunga
• Ukubetha kwentliziyo ngokungaqhelekanga
• Isihlunu nokuqaqamba kwentliziyo
• Ukoma kwelungu lobufazi okanye ukuchama kabuhlungu

Kuya kwenziwa uvavanyo olupheleleyo lomzimba. Uviwo lutyhila amehlo owomileyo kunye nomlomo owomileyo. Kunokubakho izilonda zomlomo, amazinyo abolileyo okanye ukudumba kweentsini. Oku kwenzeka ngenxa yomlomo owomileyo. Umboneleli wakho wezempilo uya kujonga emlonyeni wakho usulelo lwefungus (candida). Ulusu lunokubonisa irhashalala, uviwo lwemiphunga lungaqhelekanga, isisu siya kubethwa ngenxa yokwandiswa kwesibindi. Amalungu aya kuvavanyelwa isifo samathambo. Uvavanyo lwe-neuro luya kujonga intsilelo.

Unokwenza olu vavanyo lulandelayo:

• Gcwalisa i-chemistry yegazi kunye ne-enzyme zesibindi
• Gcwalisa ubalo lwegazi ngokwahluka
• Uhlalutyo lomchamo
• Uvavanyo lwe-Antinuclear antibodies (ANA)
• I-anti-Ro / SSA kunye ne-anti-La / SSB antibodies
• Into yeRheumatoid
• Uvavanyo lwe-cryoglobulins
• Gcwalisa amanqanaba
• Iiproteni electrophoresis
• Uvavanyo lwe-hepatitis C kunye ne-HIV (ukuba usemngciphekweni)
• Uvavanyo lwe-thyroid
• Uvavanyo lweSchirmer lokuvelisa iinyembezi
• Ukulinganisa kwe-salivary gland: nge-ultrasound okanye nge-MRI
• Isifo se-salivary gland
• Ulusu lwe-biopsy ukuba kukho irhashalala
• Uvavanyo lwamehlo ngugqirha wamehlo
• I-x-ray yesifuba

Injongo kukukhulula iimpawu.

• Amehlo awomileyo anokunyangwa ngeenyembezi, izinto zokuthambisa zamehlo, okanye ulwelo lwecyclosporine.
• Ukuba ikhoyo iCandida, inokunyangwa nge-miconazole engenashukela okanye amalungiselelo e-nystatin.
• Iiplagi ezincinci zinokufakwa kwimijelo yokuhambisa iinyembezi ukunceda iinyembezi zihlale kumphezulu wamehlo.

Iziyobisi eziguqula amachiza e-antirheumatic (DMARDs) ezifanayo nezo zisetyenziselwa i-RA zinokuphucula iimpawu zesifo seSjögren. Oku kubandakanya i-tumor necrosis factor (TNF) ethintela iziyobisi ezinje nge-Enbrel, Humira okanye i-Remicaide.

Ezinye izinto onokuzenza ukunciphisa iimpawu zibandakanya:

• Sipha amanzi imini yonke
• Hlafuna intshungama engenashukela
• Kulumkele amayeza anokubangela ukoma komlomo, njengama-antihistamines kunye neyeza zokuthambisa
• Gwema utywala

Thetha nogqirha wakho wamazinyo malunga:

• Ukuhlanjwa ngomlomo ukubuyisela iiminerali emazinyweni akho
• Amagqabi amathe
• Iziyobisi ezinceda amadlala akho amathe ukuba enze amathe ngakumbi

Ukuthintela ukubola kwamazinyo okubangelwe kukoma komlomo:

• Gxobhoza kunye nokufaka amazinyo rhoqo
• Ndwendwela ugqirha wamazinyo uyokuhlola rhoqo kunye nokucoca

Esi sifo asihlali sisongela ubomi. Isiphumo sixhomekeke kwezinye izifo onazo.

Kukho umngcipheko ophakamileyo we-lymphoma kunye nokufa kwangoko xa i-Sjögren syndrome isebenze ixesha elide, kunye nabantu abane-vasculitis, i-complements ephantsi kunye ne-cryoglobulins.

Iingxaki zinokubandakanya:

• Ukonakala kweso
• Imingxunya yamazinyo
• Ukusilela kwezintso (kunqabile)
• KwiLymphoma
• Isifo sePulmonary
• I-Vasculitis (inqabile)
• Neuropathy
• Ukudumba kwesinyi

Tsalela umnxeba umboneleli wakho ukuba uvelisa iimpawu zeSjögren syndrome.

Xerostomia - isifo Sjögren; I-Keratoconjunctivitis sicca - iSjögren; Isifo seSicca

• Iintsholongwane

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Isifo sikaMariette X. Sjögren. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 268.

USeror R, uBootsma H, uSaraux A, et al. Ukuchaza imeko yesifo kunye nokuphuculwa okunentsingiselo yeklinikhi kwisifo se-Sjögren's syndrome kunye ne-EULAR ephambili yesifo se-Sjögren's syndrome (ESSDAI) kunye nezalathiso ezichazwe kwizigulana (ESSPRI). U-Ann Rheum Dis. Ngo-2016; 75 (2): 382-389. IINKCUKACHA: 25480887 www.ncbi.nlm.nih.gov/pubmed/25480887.

U-Singh AG, u-Singh S, u-Matteson EL. Inqanaba, umngcipheko kunye noonobangela bokufa kwabaguli abane-Sjögren's syndrome: uphononongo olucwangcisiweyo kunye nohlalutyo lwe-meta-yezifundo zeqela. IRheumatology (iOxford). Ngo-2016; 55 (3): 450-460. IINKCUKACHA: 26412810 www.ncbi.nlm.nih.gov/pubmed/26412810.

Turner MD. Ukubonakaliswa ngomlomo kwezifo zenkqubo. Ku: Flint PW, Haughey BH, Lund V, et al, ii-eds. Ukutsha kweOtolaryngology. Umhla wesi-6. IPhiladelphia, PA: Elsevier Saunders; 2015: isahluko 14.