Inkqubela phambili ye-leukoencephalopathy

Inkqubela phambili ye-leukoencephalopathy ye-multifocal (PML) sisifo esinqabileyo esonakalisa izinto (i-myelin) egubungela kwaye ikhusele imithambo-luvo kumcimbi omhlophe wobuchopho.

Intsholongwane kaJohn Cunningham, okanye i-JC virus (JCV) ibangela i-PML. Intsholongwane ye-JC yaziwa ngokuba yi-polyomavirus yabantu. Ngeminyaka eli-10, uninzi lwabantu lusulelwe yile ntsholongwane nangona kungaze kubangele zimpawu. Kodwa abantu abanamajoni omzimba abuthathaka basemngciphekweni wokuphuhliswa kwe-PML. Izizathu zokungabi namandla komzimba zibandakanya:

• Intsholongwane kaGawulayo / uGawulayo (oyena nobangela uqhelekileyo we-PML ngoku ngenxa yolawulo olungcono lwe-HIV / AIDS)
• Amayeza athile acinezela amajoni omzimba abizwa ngokuba ngamachiza omzimba. La mayeza anokusetyenziselwa ukuthintela ukwaliwa komzimba okanye ukunyanga isifo esiqatha, isifo samathambo kunye nokunye ukuphazamiseka komzimba, kunye neemeko ezinxulumene noko.
• Umhlaza, njengeleukemia kunye neHodgkin lymphoma.

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Ukuphulukana nolungelelwaniso, ubuqhophololo
• Ukuphulukana nobuchule bolwimi (aphasia)
• Ukuphulukana nenkumbulo
• Iingxaki zombono
• Ukuba buthathaka kwemilenze neengalo kuya kusiba mandundu
• Ubuntu buyatshintsha

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu.

Uvavanyo lunokubandakanya:

• I-biopsy yobuchopho (kwiimeko ezinqabileyo)
• Uvavanyo lweCerebrospinal fluid lweJCV
• Ukuvavanywa kwe-CT kwengqondo
• I-Electroencephalogram (i-EEG)
• I-MRI yengqondo

Kubantu abane-HIV / AIDS, unyango lokomeleza amajoni omzimba lungakhokelela ekuchacha kwiimpawu ze-PML. Alukho olunye unyango olungqineke lusebenza kwi-PML.

I-PML yimeko esongela ubomi. Kuxhomekeke ekubeni lukhulu kangakanani na usuleleko, ukuya kuthi ga kwisiqingatha sabantu abafunyaniswe ukuba bane-PML bayasweleka kwiinyanga zokuqala ezimbalwa.

PML; Intsholongwane kaJohn Cunningham; JCV; I-polyomavirus yabantu 2; Intsholongwane yeJC

• Ingwevu nomhlophe umcimbi wengqondo
• Leukoencephalopathy

UBerger JR, uNath A. Cytomegalovirus, intsholongwane ka-Epstein-Barr, kunye nosulelo lwentsholongwane olucothayo kwinkqubo ye-nervous system. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 346.

Tan CS, Koralnik IJ. I-JC, i-BK, kunye nezinye i-polyomaviruses: i-leukoencephalopathy eqhubekayo ye-multifocal (PML). Ku: Bennett JE, Dolin R, Blaser MJ, ii-eds. Mandell, Douglas, kunye neBennett's Principles and Practice of Infectious Diseases. Umhla we-9. IPhiladelphia, PA: Elsevier; 2020: isahluko 144.