I-cerebral amyloid angiopathy

I-cerebral amyloid angiopathy (CAA) yimeko apho iiproteni ezibizwa ngokuba zii-amyloid zakha phezu kweendonga zemithambo yengqondo. I-CAA inyusa umngcipheko wokubethwa sisifo ngenxa yokopha kunye nokuwohloka komqondo.

Abantu abaneCAA baneepositi ze-amyloid kwiindonga zemithambo yegazi kwingqondo. Iprotein ihlala ibekwa naphina emzimbeni.

Owona mngcipheko uphambili ukwanda kweminyaka. I-CAA ibonakala rhoqo kubantu abadala kunama-55. Ngamanye amaxesha, idluliselwa kwiintsapho.

I-CAA inokubangela ukopha kwingqondo. Ukopha ngokufuthi kwenzeka kwiindawo ezingaphandle kwengqondo, ezibizwa ngokuba yicortex, hayi kwiindawo ezinzulu. Iimpawu zenzeka ngenxa yokuba ukopha ebuchotsheni kwenzakalisa izicwili zobuchopho. Abanye abantu baneengxaki zememori ethe ngcembe. Xa kugqityiwe ukuskena i-CT, kukho imiqondiso yokuba bophile ebuchotsheni ekusenokwenzeka ukuba abayiqondanga.

Ukuba ukopha okuninzi, iimpawu ezikhawulezileyo zivela kwaye ziyafana nokubetha. Ezi mpawu zibandakanya:

• Ukozela
• Intloko (ihlala ikwindawo ethile yentloko)
• Utshintsho lwenkqubo enokuthi iqale ngesiquphe, kubandakanya ukudideka, ukuphazamiseka kwengqondo, umbono ophindwe kabini, ukunciphisa umbono, ukutshintsha kwemvakalelo, iingxaki zokuthetha, ubuthathaka, okanye ukukhubazeka
• Ukuxhuzula
• Isiporho okanye ikhoma (kunqabile)
• Ukuhlanza

Ukuba ukuphuma kwegazi akunzima okanye kuxhaphake, iimpawu zinokubandakanya:

• Iziqendu zokudideka
• Iintloko eziza kwaye zihambe
• Ukuphulukana nokusebenza kwengqondo (isifo sengqondo esixhalabisayo)
• Ubuthathaka okanye iimvakalelo ezingaqhelekanga eziza kwaye zihambe, kwaye zibandakanya iindawo ezincinci
• Ukuxhuzula

I-CAA kunzima ukuyichonga ngokuqinisekileyo ngaphandle kwesampulu yethishu yobuchopho. Oku kuhlala kwenziwa emva kokufa okanye xa kwenziwa i-biopsy yemithambo yegazi yengqondo.

Uvavanyo lomzimba luyinto eqhelekileyo ukuba ukopha kuncinci. Kunokubakho utshintsho lomsebenzi wobuchopho. Kubalulekile ukuba ugqirha abuze imibuzo eneenkcukacha malunga neempawu kunye nembali yonyango. Iimpawu kunye neziphumo zovavanyo lomzimba kunye naluphi na uvavanyo lokucinga kunokubangela ukuba ugqirha akrokre i-CAA.

Ukulinganisa iimvavanyo zentloko enokuthi yenziwe kubandakanya:

• Ukuskena i-CT okanye ukuskena iMRI ukukhangela ukuphuma kwegazi kwingqondo
• Ukuskena kwe-MRA ukukhangela ukuphuma kwegazi okukhulu kunye nokulawula ezinye izizathu zokopha
• Ukuskena kwePET ukujonga iidipozithi zeamyloid kwingqondo

Akukho lunyango lusebenzayo. Injongo yonyango kukhulula iimpawu. Ngamanye amaxesha, ukubuyiselwa kwimeko yesiqhelo kuyafuneka kubuthathaka okanye ukungabinamandla. Oku kunokubandakanya ukunyanga ngokwasemzimbeni, emsebenzini, okanye kwintetho.

Ngamanye amaxesha, amayeza anceda ukuphucula inkumbulo, afana nalawo e-Alzheimer's disease, ayasetyenziswa.

Ukuhlutha, okwabizwa ngokuba ngama-amyloid spell, kunokunyangwa ngamachiza okulwa nokuthimba.

Isifo siye sisiba mandundu.

Iingxaki zeCAA zinokubandakanya:

• Isifo sengqondo esiyingozi
• IHydrocephalus (kunqabile)
• Ukuxhuzula
• Iziqendu eziphindaphindayo zokopha kwingqondo

Yiya kwigumbi likaxakeka okanye fowunela inombolo yongxamiseko yendawo (enje nge-911) ukuba ulahlekelwe ngesiquphe kukuhamba, imvakalelo, umbono, okanye intetho.

Amyloidosis - ubuchopho; CAA; I-angiopathy yeCongophilic

• I-Amyloidosis yeminwe
• Imithambo yengqondo

UCharidimou A, uBoulouis G, uGurol ME, okqhubekayo. Iingcamango ezivelayo kwi-angiopathy ye-cerebral amyloid. Ingqondo. Ngo-2017; 140 (7): 1829-1850. IINKCUKACHA: 28334869 pubmed.ncbi.nlm.nih.gov/28334869/.

IGreenberg SM, uCharidimou A.Ukuchongwa kwe-cerebral amyloid angiopathy: ukuvela kweenqobo zeBoston. Ukubetha. 2018; 49 (2): 491-497. IINKCUKACHA: 29335334 pubmed.ncbi.nlm.nih.gov/29335334/.

I-Kase CS, iShoamanesh A. Ukuphuma kwegazi kwangaphakathi. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ii-eds. I-Neurology kaBradley kwiKlinikhi yokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2016: isahluko 66.