Inkqubo yeatrophy ye-Multiple-cerebellar subtype

Inkqubo ye-atrophy-cerebellar subtype (MSA-C) sisifo esinqabileyo esibangela indawo ezinzulu kwingqondo, ngaphezulu ngentambo yomqolo, ukuncipha (atrophy). I-MSA-C yayisaziwa njenge-olivopontocerebellar atrophy (OPCA).

I-MSA-C inokudluliselwa kwiintsapho (kwifom enelifa). Inokuchaphazela nabantu ngaphandle kwembali yosapho eyaziwayo (ifomathi engaqhelekanga).

Abaphandi bachonge imfuza ethile ebandakanyekayo kuhlobo lwelifa olukule meko.

Unobangela we-MSA-C kubantu abanefom sporadic awaziwa. Esi sifo siya sisiba mandundu (siyaqhubeka).

I-MSA-C ixhaphake kakhulu emadodeni kunabafazi. Umndilili weminyaka yokuqalisa uneminyaka engama-54 ubudala.

Iimpawu ze-MSA-C zihlala ziqala kubancinci kubantu abanefom ezuzwe njengelifa. Olona phawu luphambili kukungakhathali (ataxia) ethe chu kancinci ukuba mandundu. Kukho iingxaki kwiingxaki zokulinganisela, ukuthetha ngokukhawuleza, kunye nobunzima bokuhamba.

Ezinye iimpawu zingabandakanya:

• Ukuhamba kwamehlo okungaqhelekanga
• Iintshukumo ezingaqhelekanga
• Iingxaki zamathumbu okanye zesinyi
• Kunzima ukugwinya
• Izandla kunye neenyawo ezibandayo
• Ubumhlophe xa umile
• Intloko ebuhlungu ngelixa umileyo okhululekileyo ngokulala phantsi
  
• Ukuqina kwemisipha okanye ukuqina, ukungqubana, ukungcangcazela
• Ukonakala kwemithambo-luvo
• Iingxaki ekuthetheni nasekulaleni ngenxa ye-spasms yeentambo zezwi
• Iingxaki zomsebenzi wesondo
• Ukubila okungaqhelekanga

Uvavanyo olunzulu lwezonyango kunye neenkqubo zovalo, kunye nokuphononongwa kwempawu kunye nembali yosapho ziyafuneka ukwenza isifo.

Kukho iimvavanyo zemfuzo zokujonga izizathu zezinye iindlela zokuphazamiseka. Kodwa, alukho uvavanyo oluthile olukhoyo kwiimeko ezininzi. I-MRI yengqondo inokubonisa utshintsho kubungakanani bezinto ezichaphazelekayo, ngakumbi xa isifo sisiba mandundu. Kodwa kunokwenzeka ukuba ube nengxaki kwaye ube neMRI yesiqhelo.

Olunye uvavanyo olunje nge-positron emission tomography (PET) lunokwenziwa ukulawula ezinye iimeko. Oku kunokubandakanya ukuginya izifundo ukubona ukuba umntu angakuginya ngokukhuselekileyo ukutya kunye nolwelo.

Akukho lonyango oluthile okanye unyango lwe-MSA-C. Injongo yokunyanga iimpawu kunye nokuthintela iingxaki. Oku kunokubandakanya:

• Amayeza okungcangcazela, afana nalawo esi sifo sikaParkinson
• Intetho, unyango nasemsebenzini
• Iindlela zokuthintela ukukrwitshwa
• Izinto zokuhamba zokunceda ukunceda ukulinganisela kunye nokuthintela ukuwa

La maqela alandelayo anokubonelela ngezixhobo kunye nenkxaso kubantu abane-MSA-C:

• Ukoyisa umanyano lweMSA- beatmsa.org/patient-programs/
• Umdibaniso weMSA- www.multiplesystematrophy.org/msa-resource/

I-MSA-C iya isiba mandundu, kwaye akukho lunyango. Imbonakalo ngokubanzi ihlwempuzekile. Kodwa, kunokuba yiminyaka ngaphambi kokuba umntu akhubazeke kakhulu.

Iingxaki zeMSA-C zibandakanya:

• Ukukrwitsha
• Usulelo olusuka ekungeniseni ukutya kwimiphunga (i-aspiration pneumonia)
• Ukwenzakala ngenxa yokuwa
• Iingxaki zesondlo ngenxa yobunzima bokuginya

Fowunela umboneleli wakho wezempilo ukuba unayo nayiphi na impawu ye-MSA-C. Uya kudinga ukubonwa ngugqirha wemithambo-luvo. Lo ngugqirha ophatha iingxaki zenkqubo yemithambo-luvo.

I-MSA-C; I-atrophy ye-Cerebellar yeenkqubo ezininzi; Olivopontocerebellar yoma; I-OPCA; Ukwehla kwe-Olivopontocerebellar

• Inkqubo ye-nervous central kunye ne-peripheral system

UCiolli L, uKrismer F, uNicoletti F, uGqirha oLawulayo. Uhlaziyo kwi-subtype ye-cerebellar yenkqubo ye-atrophy eninzi. ICerebellum Ataxias. Ngo-2014; 1-14. IINKCUKACHA: 26331038 pubmed.ncbi.nlm.nih.gov/26331038/.

UGilman S, Wenning GK, Low PA, et al. Isiteyitimenti sesibini semvumelwano malunga nokuchongwa kwenkqubo yeatrophy. Neurology. Ngo-2008; 71 (9): 670-676. IINKCUKACHA: I-18725592 epapashwe.ncbi.nlm.nih.gov/18725592/.

Isifo sikaJancovic J. Parkinson kunye nezinye iingxaki zokuhamba. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ii-eds. I-Neurology kaBradley kwiKlinikhi yokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2016: isahluko 96.

Ma MJ. I-Biopsy pathology ye-neurodegenerative yokuphazamiseka kubantu abadala. Ku: Perry A, Brat DJ, ii-eds. Ukusebenza kweNeuropathology yoNyango: Indlela yokuChonga. Ngomhla wesi-2. IPhiladelphia, PA: Elsevier, 2018: isahluko 27.

UWalsh RR, uKrismer F, uGalpern WR, et al. Iingcebiso ngenkqubo yeendlela ezininzi zophando zendlela yokuqhuba uphando. Neurology. 2018; 90 (2): 74-82. IINKCUKACHA: 29237794 pubmed.ncbi.nlm.nih.gov/29237794/.